7dcf - Revision history

OCA at 10:53, 27 March 2024

2024-03-27T10:53:21Z

←Older revision		Revision as of 10:53, 27 March 2024
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	==Crystal structure of EHMT2 SET domain in complex with compound 10==		==Crystal structure of EHMT2 SET domain in complex with compound 10==
-	<StructureSection load='7dcf' size='340' side='right'caption='[[7dcf]]' scene=''>	+	<StructureSection load='7dcf' size='340' side='right'caption='[[7dcf]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7DCF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7DCF FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7dcf]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7DCF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7DCF FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7dcf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7dcf OCA], [https://pdbe.org/7dcf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7dcf RCSB], [https://www.ebi.ac.uk/pdbsum/7dcf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7dcf ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=H30:5-methoxy-6-(1-methyl-2,3,4,7-tetrahydroazepin-5-yl)spiro[cyclobutane-1,3-indole]-2-amine'>H30</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7dcf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7dcf OCA], [https://pdbe.org/7dcf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7dcf RCSB], [https://www.ebi.ac.uk/pdbsum/7dcf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7dcf ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/EHMT2_HUMAN EHMT2_HUMAN] Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also mediates monomethylation of 'Lys-56' of histone H3 (H3K56me1) in G1 phase, leading to promote interaction between histone H3 and PCNA and regulating DNA replication. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. May also methylate histone H1. In addition to the histone methyltransferase activity, also methylates non-histone proteins: mediates dimethylation of 'Lys-373' of p53/TP53. Also methylates CDYL, WIZ, ACIN1, DNMT1, HDAC1, ERCC6, KLF12 and itself.<ref>PMID:8457211</ref> <ref>PMID:11316813</ref> <ref>PMID:18438403</ref> <ref>PMID:20118233</ref> <ref>PMID:22387026</ref>
		+
		+	==See Also==
		+	*[[Histone methyltransferase 3D structures\|Histone methyltransferase 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Katayama K]]		[[Category: Katayama K]]
	[[Category: Suzuki M]]		[[Category: Suzuki M]]

OCA at 11:03, 10 February 2021

2021-02-10T11:03:01Z

←Older revision		Revision as of 11:03, 10 February 2021
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-	'''Unreleased structure'''

-	~~The entry 7dcf is ON HOLD until Oct 26 2022~~	+	==Crystal structure of EHMT2 SET domain in complex with compound 10==
-		+	<StructureSection load='7dcf' size='340' side='right'caption='[[7dcf]]' scene=''>
-	~~Authors: Suzuki, M., Katayama, K.~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7DCF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7DCF FirstGlance]. <br>
-	~~Description:~~ Crystal structure of EHMT2 SET domain in complex with compound 10	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7dcf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7dcf OCA], [https://pdbe.org/7dcf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7dcf RCSB], [https://www.ebi.ac.uk/pdbsum/7dcf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7dcf ProSAT]</span></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	</table>
-	[[~~Category~~: ~~Suzuki~~, M]]	+	__TOC__
-	[[Category: Katayama, K]]	+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Katayama K]]
		+	[[Category: Suzuki M]]

OCA at 11:05, 16 December 2020

2020-12-16T11:05:02Z

←Older revision		Revision as of 11:05, 16 December 2020
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7dcf is ON HOLD	+	The entry 7dcf is ON HOLD until Oct 26 2022

	Authors: Suzuki, M., Katayama, K.		Authors: Suzuki, M., Katayama, K.

OCA: Protected "7dcf" [edit=sysop:move=sysop]

2020-11-04T05:29:41Z

Protected "7dcf" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:29, 4 November 2020

OCA: New page: '''Unreleased structure''' The entry 7dcf is ON HOLD Authors: Suzuki, M., Katayama, K. Description: Crystal structure of EHMT2 SET domain in complex with compound 10 [[Category: Unrele...

2020-11-04T05:29:39Z

New page: '''Unreleased structure''' The entry 7dcf is ON HOLD Authors: Suzuki, M., Katayama, K. Description: Crystal structure of EHMT2 SET domain in complex with compound 10 [[Category: Unrele...

New page

'''Unreleased structure'''

The entry 7dcf is ON HOLD

Authors: Suzuki, M., Katayama, K.

Description: Crystal structure of EHMT2 SET domain in complex with compound 10
[[Category: Unreleased Structures]]
[[Category: Suzuki, M]]
[[Category: Katayama, K]]