7dd5 - Revision history

OCA at 07:48, 25 June 2021

2021-06-25T07:48:37Z

←Older revision		Revision as of 07:48, 25 June 2021
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	==Structure of Calcium-Sensing Receptor in complex with NPS-2143==		==Structure of Calcium-Sensing Receptor in complex with NPS-2143==
-	<StructureSection load='7dd5' size='340' side='right'caption='[[7dd5]]' scene=''>	+	<StructureSection load='7dd5' size='340' side='right'caption='[[7dd5]], [[Resolution\|resolution]] 3.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7DD5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7DD5 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7dd5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Chick Chick]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7DD5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7DD5 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7dd5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7dd5 OCA], [https://pdbe.org/7dd5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7dd5 RCSB], [https://www.ebi.ac.uk/pdbsum/7dd5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7dd5 ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=TRP:TRYPTOPHAN'>TRP</scene>, <scene name='pdbligand=YP1:2-chloro-6-[(2R)-2-hydroxy-3-{[2-methyl-1-(naphthalen-2-yl)propan-2-yl]amino}propoxy]benzonitrile'>YP1</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7dd5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7dd5 OCA], [https://pdbe.org/7dd5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7dd5 RCSB], [https://www.ebi.ac.uk/pdbsum/7dd5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7dd5 ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Calcium-sensing receptor (CaSR) is a class C G protein-coupled receptor (GPCR) that plays an important role in calcium homeostasis and parathyroid hormone secretion. Here, we present multiple cryo-electron microscopy structures of full-length CaSR in distinct ligand-bound states. Ligands (Ca(2+) and l-tryptophan) bind to the extracellular domain of CaSR and induce large-scale conformational changes, leading to the closure of two heptahelical transmembrane domains (7TMDs) for activation. The positive modulator (evocalcet) and the negative allosteric modulator (NPS-2143) occupy the similar binding pocket in 7TMD. The binding of NPS-2143 causes a considerable rearrangement of two 7TMDs, forming an inactivated TM6/TM6 interface. Moreover, a total of 305 disease-causing missense mutations of CaSR have been mapped to the structure in the active state, creating hotspot maps of five clinical endocrine disorders. Our results provide a structural framework for understanding the activation, allosteric modulation mechanism, and disease therapy for class C GPCRs.
		+
		+	Structural basis for activation and allosteric modulation of full-length calcium-sensing receptor.,Wen T, Wang Z, Chen X, Ren Y, Lu X, Xing Y, Lu J, Chang S, Zhang X, Shen Y, Yang X Sci Adv. 2021 Jun 4;7(23). pii: 7/23/eabg1483. doi: 10.1126/sciadv.abg1483. Print, 2021 Jun. PMID:34088669<ref>PMID:34088669</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7dd5" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Chick]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Shen YQ]]	+	[[Category: Shen, Y Q]]
-	[[Category: Wen TL]]	+	[[Category: Wen, T L]]
-	[[Category: Yang X]]	+	[[Category: Yang, X]]
		+	[[Category: Calcium-sensing receptor]]
		+	[[Category: Casr]]
		+	[[Category: Membrane protein]]
		+	[[Category: Nps-2143]]

OCA at 14:46, 17 June 2021

2021-06-17T14:46:08Z

←Older revision		Revision as of 14:46, 17 June 2021
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-	'''Unreleased structure'''

-	~~The entry~~ 7dd5 ~~is ON HOLD~~	+	==Structure of Calcium-Sensing Receptor in complex with NPS-2143==
-		+	<StructureSection load='7dd5' size='340' side='right'caption='[[7dd5]]' scene=''>
-	~~Authors~~: ~~Wen~~, T.L., ~~Yang~~, X., ~~Shen~~, Y.Q.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7DD5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7DD5 FirstGlance]. <br>
-	~~Description: Structure of Calcium-Sensing Receptor in complex with NPS-2143~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7dd5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7dd5 OCA], [https://pdbe.org/7dd5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7dd5 RCSB], [https://www.ebi.ac.uk/pdbsum/7dd5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7dd5 ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
-	[[Category: ~~Yang, X~~]]	+	__TOC__
-	[[Category: Wen~~, T.L~~]]	+	</StructureSection>
-	[[Category: ~~Shen, Y.Q~~]]	+	[[Category: Large Structures]]
		+	[[Category: Shen YQ]]
		+	[[Category: Wen TL]]
		+	[[Category: Yang X]]

OCA at 13:20, 2 June 2021

2021-06-02T13:20:33Z

←Older revision		Revision as of 13:20, 2 June 2021
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	The entry 7dd5 is ON HOLD		The entry 7dd5 is ON HOLD

-	Authors:	+	Authors: Wen, T.L., Yang, X., Shen, Y.Q.

-	Description:	+	Description: Structure of Calcium-Sensing Receptor in complex with NPS-2143
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
		+	[[Category: Yang, X]]
		+	[[Category: Wen, T.L]]
		+	[[Category: Shen, Y.Q]]

OCA: Protected "7dd5" [edit=sysop:move=sysop]

2020-11-04T05:31:44Z

Protected "7dd5" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:31, 4 November 2020

OCA: New page: '''Unreleased structure''' The entry 7dd5 is ON HOLD Authors: Description: Category: Unreleased Structures

2020-11-04T05:31:43Z

New page: '''Unreleased structure''' The entry 7dd5 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7dd5 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]