7dwy - Revision history

OCA at 14:58, 17 June 2021

2021-06-17T14:58:20Z

←Older revision		Revision as of 14:58, 17 June 2021
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	==S protein of SARS-CoV-2 in the locked conformation==		==S protein of SARS-CoV-2 in the locked conformation==
-	<StructureSection load='7dwy' size='340' side='right'caption='[[7dwy]]' scene=''>	+	<StructureSection load='7dwy' size='340' side='right'caption='[[7dwy]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7DWY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7DWY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7dwy]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/2019-ncov 2019-ncov]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7DWY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7DWY FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7dwy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7dwy OCA], [https://pdbe.org/7dwy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7dwy RCSB], [https://www.ebi.ac.uk/pdbsum/7dwy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7dwy ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EIC:LINOLEIC+ACID'>EIC</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">S, 2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2697049 2019-nCoV])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7dwy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7dwy OCA], [https://pdbe.org/7dwy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7dwy RCSB], [https://www.ebi.ac.uk/pdbsum/7dwy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7dwy ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[https://www.uniprot.org/uniprot/SPIKE_SARS2 SPIKE_SARS2]] attaches the virion to the cell membrane by interacting with host receptor, initiating the infection (By similarity). Binding to human ACE2 receptor and internalization of the virus into the endosomes of the host cell induces conformational changes in the Spike glycoprotein (PubMed:32142651, PubMed:32075877, PubMed:32155444). Uses also human TMPRSS2 for priming in human lung cells which is an essential step for viral entry (PubMed:32142651). Proteolysis by cathepsin CTSL may unmask the fusion peptide of S2 and activate membranes fusion within endosomes.[HAMAP-Rule:MF_04099]<ref>PMID:32075877</ref> <ref>PMID:32142651</ref> <ref>PMID:32155444</ref> mediates fusion of the virion and cellular membranes by acting as a class I viral fusion protein. Under the current model, the protein has at least three conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.[HAMAP-Rule:MF_04099] Acts as a viral fusion peptide which is unmasked following S2 cleavage occurring upon virus endocytosis.[HAMAP-Rule:MF_04099]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: 2019-ncov]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Chi XM]]	+	[[Category: Chi, X M]]
-	[[Category: Guo YY]]	+	[[Category: Guo, Y Y]]
-	[[Category: Li YN]]	+	[[Category: Li, Y N]]
-	[[Category: Xia L]]	+	[[Category: Xia, L]]
-	[[Category: Yan RH]]	+	[[Category: Yan, R H]]
-	[[Category: Ye FF]]	+	[[Category: Ye, F F]]
-	[[Category: Zhang YY]]	+	[[Category: Zhang, Y Y]]
-	[[Category: Zhong XY]]	+	[[Category: Zhong, X Y]]
-	[[Category: Zhou Q]]	+	[[Category: Zhou, Q]]
		+	[[Category: Sars-cov-2]]
		+	[[Category: Virus]]

OCA at 10:32, 31 March 2021

2021-03-31T10:32:46Z

←Older revision		Revision as of 10:32, 31 March 2021
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-	'''Unreleased structure'''

-	~~The entry~~ 7dwy ~~is ON HOLD~~	+	==S protein of SARS-CoV-2 in the locked conformation==
-		+	<StructureSection load='7dwy' size='340' side='right'caption='[[7dwy]]' scene=''>
-	~~Authors~~: ~~Yan, R~~.H.~~, Zhang, Y~~.Y.~~, Li, Y~~.N.~~, Ye, F~~.F., ~~Guo, Y~~.Y., ~~Xia, L~~., ~~Zhong, X~~.Y., ~~Chi, X~~.M., ~~Zhou, Q~~.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7DWY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7DWY FirstGlance]. <br>
-	~~Description: S protein of SARS-CoV-2 in the locked conformation~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7dwy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7dwy OCA], [https://pdbe.org/7dwy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7dwy RCSB], [https://www.ebi.ac.uk/pdbsum/7dwy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7dwy ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
-	[[Category: ~~Xia, L~~]]	+	__TOC__
-	[[Category: ~~Ye, F.F~~]]	+	</StructureSection>
-	[[Category: ~~Zhou, Q~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Li, Y.N~~]]	+	[[Category: Chi XM]]
-	[[Category: ~~Guo, Y.Y~~]]	+	[[Category: Guo YY]]
-	[[Category: ~~Zhang, Y.Y~~]]	+	[[Category: Li YN]]
-	[[Category: ~~Yan, R.H~~]]	+	[[Category: Xia L]]
-	[[Category: Zhong~~, X.Y~~]]	+	[[Category: Yan RH]]
-	[[Category: ~~Chi, X.M~~]]	+	[[Category: Ye FF]]
		+	[[Category: Zhang YY]]
		+	[[Category: Zhong XY]]
		+	[[Category: Zhou Q]]

OCA: Protected "7dwy" [edit=sysop:move=sysop]

2021-01-27T06:40:04Z

Protected "7dwy" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:40, 27 January 2021

OCA: New page: '''Unreleased structure''' The entry 7dwy is ON HOLD Authors: Yan, R.H., Zhang, Y.Y., Li, Y.N., Ye, F.F., Guo, Y.Y., Xia, L., Zhong, X.Y., Chi, X.M., Zhou, Q. Description: S protein of...

2021-01-27T06:40:03Z

New page: '''Unreleased structure''' The entry 7dwy is ON HOLD Authors: Yan, R.H., Zhang, Y.Y., Li, Y.N., Ye, F.F., Guo, Y.Y., Xia, L., Zhong, X.Y., Chi, X.M., Zhou, Q. Description: S protein of...

New page

'''Unreleased structure'''

The entry 7dwy is ON HOLD

Authors: Yan, R.H., Zhang, Y.Y., Li, Y.N., Ye, F.F., Guo, Y.Y., Xia, L., Zhong, X.Y., Chi, X.M., Zhou, Q.

Description: S protein of SARS-CoV-2 in the locked conformation
[[Category: Unreleased Structures]]
[[Category: Xia, L]]
[[Category: Ye, F.F]]
[[Category: Zhou, Q]]
[[Category: Li, Y.N]]
[[Category: Guo, Y.Y]]
[[Category: Zhang, Y.Y]]
[[Category: Yan, R.H]]
[[Category: Zhong, X.Y]]
[[Category: Chi, X.M]]