7ecg - Revision history

OCA at 10:54, 27 March 2024

2024-03-27T10:54:36Z

←Older revision		Revision as of 10:54, 27 March 2024
Line 3:		Line 3:
	<StructureSection load='7ecg' size='340' side='right'caption='[[7ecg]], [[Resolution\|resolution]] 1.97Å' scene=''>		<StructureSection load='7ecg' size='340' side='right'caption='[[7ecg]], [[Resolution\|resolution]] 1.97Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[7ecg]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ECG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ECG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7ecg]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ECG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ECG FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BA:BARIUM+ION'>BA</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.97Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BA:BARIUM+ION'>BA</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ecg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ecg OCA], [https://pdbe.org/7ecg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ecg RCSB], [https://www.ebi.ac.uk/pdbsum/7ecg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ecg ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ecg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ecg OCA], [https://pdbe.org/7ecg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ecg RCSB], [https://www.ebi.ac.uk/pdbsum/7ecg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ecg ProSAT]</span></td></tr>
	</table>		</table>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	The hexanucleotide repeat expansion, GGGGCC (G4C2), within the first intron of the C9orf72 gene is known to be the most common genetic cause of both amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The G4C2 repeat expansions, either DNA or RNA, are able to form G-quadruplexes which induce toxicity leading to ALS/FTD. Herein, we report a novel crystal structure of d(G4C2)2 that self-associates to form an eight-layer parallel tetrameric G-quadruplex. Two d(G4C2)2 associate together as a parallel dimeric G-quadruplex which folds into a tetramer via 5'-to-5' arrangements. Each dimer consists of four G-tetrads connected by two CC propeller loops. Especially, the 3'-end cytosines protrude out and form C.C+C.C+/ C.CC.C+ quadruple base pair or C*C.C+ triple base pair stacking on the dimeric block. Our work sheds light on the G-quadruplexes adopted by d(G4C2) and yields the invaluable structural details for the development of small molecules to tackle neurodegenerative diseases, ALS and FTD.
-
-	Crystal structure of parallel G-quadruplex formed by the two-repeat ALS- and FTD-related GGGGCC sequence.,Geng Y, Liu C, Cai Q, Luo Z, Miao H, Shi X, Xu N, Fung CP, Choy TT, Yan B, Li N, Qian P, Zhou B, Zhu G Nucleic Acids Res. 2021 May 28. pii: 6287844. doi: 10.1093/nar/gkab302. PMID:34048588<ref>PMID:34048588</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 7ecg" style="background-color:#fffaf0;"></div>
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Cai, Q]]	+	[[Category: Cai Q]]
-	[[Category: Geng, Y]]	+	[[Category: Geng Y]]
-	[[Category: Liu, C]]	+	[[Category: Liu C]]
-	[[Category: Luo, Z]]	+	[[Category: Luo Z]]
-	[[Category: Zhu, G]]	+	[[Category: Zhu G]]
-	~~[[Category: Dna]]~~	+
-	~~[[Category: G-quadruplex~~]]	+

OCA at 07:48, 25 June 2021

2021-06-25T07:48:58Z

←Older revision		Revision as of 07:48, 25 June 2021
Line 1:		Line 1:

	==Crystal Structure of d(G4C2)2-Ba in F222 space group==		==Crystal Structure of d(G4C2)2-Ba in F222 space group==
-	<StructureSection load='7ecg' size='340' side='right'caption='[[7ecg]]' scene=''>	+	<StructureSection load='7ecg' size='340' side='right'caption='[[7ecg]], [[Resolution\|resolution]] 1.97Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ECG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ECG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7ecg]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ECG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ECG FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ecg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ecg OCA], [https://pdbe.org/7ecg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ecg RCSB], [https://www.ebi.ac.uk/pdbsum/7ecg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ecg ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BA:BARIUM+ION'>BA</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ecg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ecg OCA], [https://pdbe.org/7ecg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ecg RCSB], [https://www.ebi.ac.uk/pdbsum/7ecg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ecg ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The hexanucleotide repeat expansion, GGGGCC (G4C2), within the first intron of the C9orf72 gene is known to be the most common genetic cause of both amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The G4C2 repeat expansions, either DNA or RNA, are able to form G-quadruplexes which induce toxicity leading to ALS/FTD. Herein, we report a novel crystal structure of d(G4C2)2 that self-associates to form an eight-layer parallel tetrameric G-quadruplex. Two d(G4C2)2 associate together as a parallel dimeric G-quadruplex which folds into a tetramer via 5'-to-5' arrangements. Each dimer consists of four G-tetrads connected by two CC propeller loops. Especially, the 3'-end cytosines protrude out and form C.C+C.C+/ C.CC.C+ quadruple base pair or C*C.C+ triple base pair stacking on the dimeric block. Our work sheds light on the G-quadruplexes adopted by d(G4C2) and yields the invaluable structural details for the development of small molecules to tackle neurodegenerative diseases, ALS and FTD.
		+
		+	Crystal structure of parallel G-quadruplex formed by the two-repeat ALS- and FTD-related GGGGCC sequence.,Geng Y, Liu C, Cai Q, Luo Z, Miao H, Shi X, Xu N, Fung CP, Choy TT, Yan B, Li N, Qian P, Zhou B, Zhu G Nucleic Acids Res. 2021 May 28. pii: 6287844. doi: 10.1093/nar/gkab302. PMID:34048588<ref>PMID:34048588</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7ecg" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Cai Q]]	+	[[Category: Cai, Q]]
-	[[Category: Geng Y]]	+	[[Category: Geng, Y]]
-	[[Category: Liu C]]	+	[[Category: Liu, C]]
-	[[Category: Luo Z]]	+	[[Category: Luo, Z]]
-	[[Category: Zhu G]]	+	[[Category: Zhu, G]]
		+	[[Category: Dna]]
		+	[[Category: G-quadruplex]]

OCA at 12:13, 9 June 2021

2021-06-09T12:13:33Z

←Older revision		Revision as of 12:13, 9 June 2021
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 7ecg is ~~ON HOLD until Paper Publication~~	+	==Crystal Structure of d(G4C2)2-Ba in F222 space group==
-		+	<StructureSection load='7ecg' size='340' side='right'caption='[[7ecg]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ECG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ECG FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ecg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ecg OCA], [https://pdbe.org/7ecg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ecg RCSB], [https://www.ebi.ac.uk/pdbsum/7ecg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ecg ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Cai Q]]
		+	[[Category: Geng Y]]
		+	[[Category: Liu C]]
		+	[[Category: Luo Z]]
		+	[[Category: Zhu G]]

OCA at 09:15, 31 March 2021

2021-03-31T09:15:04Z

←Older revision		Revision as of 09:15, 31 March 2021
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7ecg is ON HOLD	+	The entry 7ecg is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7ecg" [edit=sysop:move=sysop]

2021-03-24T05:22:31Z

Protected "7ecg" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:22, 24 March 2021

OCA: New page: '''Unreleased structure''' The entry 7ecg is ON HOLD Authors: Description: Category: Unreleased Structures

2021-03-24T05:22:30Z

New page: '''Unreleased structure''' The entry 7ecg is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7ecg is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]