7ef7 - Revision history

OCA at 16:52, 29 November 2023

2023-11-29T16:52:11Z

←Older revision		Revision as of 16:52, 29 November 2023
Line 3:		Line 3:
	<StructureSection load='7ef7' size='340' side='right'caption='[[7ef7]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='7ef7' size='340' side='right'caption='[[7ef7]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[7ef7]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7EF7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7EF7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7ef7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7EF7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7EF7 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=XMP:XANTHOSINE-5-MONOPHOSPHATE'>XMP</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.5Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=XMP:XANTHOSINE-5-MONOPHOSPHATE'>XMP</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ef7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ef7 OCA], [https://pdbe.org/7ef7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ef7 RCSB], [https://www.ebi.ac.uk/pdbsum/7ef7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ef7 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ef7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ef7 OCA], [https://pdbe.org/7ef7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ef7 RCSB], [https://www.ebi.ac.uk/pdbsum/7ef7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ef7 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q9SKY5_ARATH Q9SKY5_ARATH]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 20:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Arabidopsis thaliana]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Rhee, S]]	+	[[Category: Rhee S]]
-	[[Category: Yang, S]]	+	[[Category: Yang S]]
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Xmpase~~]]	+

OCA at 10:20, 18 May 2022

2022-05-18T10:20:45Z

←Older revision		Revision as of 10:20, 18 May 2022
Line 1:		Line 1:

	==Crystal Structure of Xanthosine monophosphate phosphatase complex with XMP==		==Crystal Structure of Xanthosine monophosphate phosphatase complex with XMP==
-	<StructureSection load='7ef7' size='340' side='right'caption='[[7ef7]]' scene=''>	+	<StructureSection load='7ef7' size='340' side='right'caption='[[7ef7]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7EF7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7EF7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7ef7]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7EF7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7EF7 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ef7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ef7 OCA], [https://pdbe.org/7ef7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ef7 RCSB], [https://www.ebi.ac.uk/pdbsum/7ef7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ef7 ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=XMP:XANTHOSINE-5-MONOPHOSPHATE'>XMP</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ef7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ef7 OCA], [https://pdbe.org/7ef7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ef7 RCSB], [https://www.ebi.ac.uk/pdbsum/7ef7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ef7 ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	In plants, guanosine monophosphate (GMP) is synthesized from adenosine monophosphate via inosine monophosphate and xanthosine monophosphate (XMP) in the cytosol. It has been shown recently that the catabolic route for adenylate-derived nucleotides bifurcates at XMP from this biosynthetic route. Dephosphorylation of XMP and GMP by as yet unknown phosphatases can initiate cytosolic purine nucleotide catabolism. Here we show that Arabidopsis thaliana possesses a highly XMP-specific phosphatase (XMPP) which is conserved in vascular plants. We demonstrate that XMPP catalyzes the irreversible entry reaction of adenylate-derived nucleotides into purine nucleotide catabolism in vivo, whereas the guanylates enter catabolism via an unidentified GMP phosphatase and guanosine deaminase which are important to maintain purine nucleotide homeostasis. We also present a crystal structure and mutational analysis of XMPP providing a rationale for its exceptionally high substrate specificity, which is likely required for the efficient catalysis of the very small XMP pool in vivo.
		+
		+	Initiation of cytosolic plant purine nucleotide catabolism involves a monospecific xanthosine monophosphate phosphatase.,Heinemann KJ, Yang SY, Straube H, Medina-Escobar N, Varbanova-Herde M, Herde M, Rhee S, Witte CP Nat Commun. 2021 Nov 25;12(1):6846. doi: 10.1038/s41467-021-27152-4. PMID:34824243<ref>PMID:34824243</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7ef7" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Rhee S]]	+	[[Category: Rhee, S]]
-	[[Category: Yang S]]	+	[[Category: Yang, S]]
		+	[[Category: Hydrolase]]
		+	[[Category: Xmpase]]

OCA at 14:29, 3 November 2021

2021-11-03T14:29:25Z

←Older revision		Revision as of 14:29, 3 November 2021
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 7ef7 ~~is ON HOLD until Paper Publication~~	+	==Crystal Structure of Xanthosine monophosphate phosphatase complex with XMP==
-		+	<StructureSection load='7ef7' size='340' side='right'caption='[[7ef7]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7EF7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7EF7 FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ef7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ef7 OCA], [https://pdbe.org/7ef7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ef7 RCSB], [https://www.ebi.ac.uk/pdbsum/7ef7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ef7 ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Rhee S]]
		+	[[Category: Yang S]]

OCA: Protected "7ef7" [edit=sysop:move=sysop]

2021-03-31T09:16:17Z

Protected "7ef7" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:16, 31 March 2021

OCA: New page: '''Unreleased structure''' The entry 7ef7 is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

2021-03-31T09:16:16Z

New page: '''Unreleased structure''' The entry 7ef7 is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7ef7 is ON HOLD until Paper Publication

Authors:

Description:
[[Category: Unreleased Structures]]