7eja - Revision history

OCA at 16:55, 29 November 2023

2023-11-29T16:55:07Z

←Older revision		Revision as of 16:55, 29 November 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[7eja]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7EJA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7EJA FirstGlance]. <br>		<table><tr><td colspan='2'>[[7eja]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7EJA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7EJA FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CZX:4-[(1~{S})-1-(2,3-dimethylphenyl)ethyl]-1~{H}-imidazole'>CZX</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 3.6Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CZX:4-[(1~{S})-1-(2,3-dimethylphenyl)ethyl]-1~{H}-imidazole'>CZX</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7eja FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7eja OCA], [https://pdbe.org/7eja PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7eja RCSB], [https://www.ebi.ac.uk/pdbsum/7eja PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7eja ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7eja FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7eja OCA], [https://pdbe.org/7eja PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7eja RCSB], [https://www.ebi.ac.uk/pdbsum/7eja PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7eja ProSAT]</span></td></tr>
	</table>		</table>

OCA at 06:22, 26 October 2022

2022-10-26T06:22:20Z

←Older revision		Revision as of 06:22, 26 October 2022
Line 1:		Line 1:

-	====	+	==Structure of the alpha2A-adrenergic receptor GoA signaling complex bound to dexmedetomidine==
-	<StructureSection load='7eja' size='340' side='right'caption='[[7eja]]' scene=''>	+	<StructureSection load='7eja' size='340' side='right'caption='[[7eja]], [[Resolution\|resolution]] 3.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7eja]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7EJA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7EJA FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7eja FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7eja OCA], [https://pdbe.org/7eja PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7eja RCSB], [https://www.ebi.ac.uk/pdbsum/7eja PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7eja ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CZX:4-[(1~{S})-1-(2,3-dimethylphenyl)ethyl]-1~{H}-imidazole'>CZX</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7eja FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7eja OCA], [https://pdbe.org/7eja PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7eja RCSB], [https://www.ebi.ac.uk/pdbsum/7eja PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7eja ProSAT]</span></td></tr>
	</table>		</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/GNAO_HUMAN GNAO_HUMAN] Early infantile epileptic encephalopathy. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/GNAO_HUMAN GNAO_HUMAN] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(o) protein function is not clear. Stimulated by RGS14.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The alpha2A adrenergic receptor (alpha2AAR) is a G protein (heterotrimeric guanine nucleotide-binding protein)-coupled receptor that mediates important physiological functions in response to the endogenous neurotransmitters norepinephrine and epinephrine, as well as numerous chemically distinct drugs. However, the molecular mechanisms of drug actions remain poorly understood. Here, we report the cryo-electron microscopy structures of the human alpha2AAR-GoA complex bound to norepinephrine and three imidazoline derivatives (brimonidine, dexmedetomidine, and oxymetazoline). Together with mutagenesis and functional data, these structures provide important insights into the molecular basis of ligand recognition, activation, and signaling at the alpha2AAR. Further structural analyses uncover different molecular determinants between alpha2AAR and betaARs for recognition of norepinephrine and key regions that determine the G protein coupling selectivity. Overall, our studies provide a framework for understanding the signal transduction of the adrenergic system at the atomic level, which will facilitate rational structure-based discovery of safer and more effective medications for alpha2AAR.
		+
		+	Structural insights into ligand recognition, activation, and signaling of the alpha2A adrenergic receptor.,Xu J, Cao S, Hubner H, Weikert D, Chen G, Lu Q, Yuan D, Gmeiner P, Liu Z, Du Y Sci Adv. 2022 Mar 4;8(9):eabj5347. doi: 10.1126/sciadv.abj5347. Epub 2022 Mar 4. PMID:35245122<ref>PMID:35245122</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7eja" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Adrenergic receptor 3D structures\|Adrenergic receptor 3D structures]]
		+	*[[Transducin 3D structures\|Transducin 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Z~~-disk~~]]	+	[[Category: Mus musculus]]
		+	[[Category: Cao S]]
		+	[[Category: Du Y]]
		+	[[Category: Liu Z]]
		+	[[Category: Xu J]]

OCA at 09:44, 13 April 2022

2022-04-13T09:44:40Z

←Older revision		Revision as of 09:44, 13 April 2022
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 7eja ~~is ON HOLD until Paper Publication~~	+	====
-		+	<StructureSection load='7eja' size='340' side='right'caption='[[7eja]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7eja FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7eja OCA], [https://pdbe.org/7eja PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7eja RCSB], [https://www.ebi.ac.uk/pdbsum/7eja PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7eja ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Z-disk]]

OCA at 15:27, 15 December 2021

2021-12-15T15:27:05Z

←Older revision		Revision as of 15:27, 15 December 2021
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7eja is ON HOLD	+	The entry 7eja is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7eja" [edit=sysop:move=sysop]

2021-04-07T04:33:29Z

Protected "7eja" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:33, 7 April 2021

OCA: New page: '''Unreleased structure''' The entry 7eja is ON HOLD Authors: Description: Category: Unreleased Structures

2021-04-07T04:33:28Z

New page: '''Unreleased structure''' The entry 7eja is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7eja is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]