OCA at 08:07, 10 April 2024

2024-04-10T08:07:58Z

←Older revision		Revision as of 08:07, 10 April 2024
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-	====	+	==Fzd7 -Gs complex==
-	<StructureSection load='7evw' size='340' side='right'caption='[[7evw]]' scene=''>	+	<StructureSection load='7evw' size='340' side='right'caption='[[7evw]], [[Resolution\|resolution]] 3.22Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7evw]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7EVW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7EVW FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7evw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7evw OCA], [https://pdbe.org/7evw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7evw RCSB], [https://www.ebi.ac.uk/pdbsum/7evw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7evw ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 3.22Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7evw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7evw OCA], [https://pdbe.org/7evw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7evw RCSB], [https://www.ebi.ac.uk/pdbsum/7evw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7evw ProSAT]</span></td></tr>
	</table>		</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/GNAS2_HUMAN GNAS2_HUMAN] Pseudopseudohypoparathyroidism;Pseudohypoparathyroidism type 1A;Progressive osseous heteroplasia;Polyostotic fibrous dysplasia;Monostotic fibrous dysplasia;Pseudohypoparathyroidism type 1C;Pseudohypoparathyroidism type 1B;McCune-Albright syndrome. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. Most affected individuals have defects in methylation of the gene. In some cases microdeletions involving the STX16 appear to cause loss of methylation at exon A/B of GNAS, resulting in PHP1B. Paternal uniparental isodisomy have also been observed. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/GNAS2_HUMAN GNAS2_HUMAN] Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein-coupled receptors (GPCRs) (PubMed:17110384). Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP (PubMed:26206488, PubMed:8702665). GNAS functions downstream of several GPCRs, including beta-adrenergic receptors (PubMed:21488135). Stimulates the Ras signaling pathway via RAPGEF2 (PubMed:12391161).<ref>PMID:12391161</ref> <ref>PMID:17110384</ref> <ref>PMID:21488135</ref> <ref>PMID:26206488</ref> <ref>PMID:8702665</ref>
		+
		+	==See Also==
		+	*[[Transducin 3D structures\|Transducin 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Z-disk~~]]	+	[[Category: Chen B]]
		+	[[Category: Xu F]]
		+	[[Category: Xu L]]

OCA at 10:18, 4 August 2021

2021-08-04T10:18:24Z

←Older revision		Revision as of 10:18, 4 August 2021
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-	'''Unreleased structure'''

-	~~The entry~~ 7evw ~~is ON HOLD~~	+	====
-		+	<StructureSection load='7evw' size='340' side='right'caption='[[7evw]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7evw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7evw OCA], [https://pdbe.org/7evw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7evw RCSB], [https://www.ebi.ac.uk/pdbsum/7evw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7evw ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Z-disk]]

OCA: Protected "7evw" [edit=sysop:move=sysop]

2021-06-02T13:23:18Z

Protected "7evw" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:23, 2 June 2021

OCA: New page: '''Unreleased structure''' The entry 7evw is ON HOLD Authors: Description: Category: Unreleased Structures

2021-06-02T13:23:18Z

New page: '''Unreleased structure''' The entry 7evw is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7evw is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

7evw - Revision history

OCA at 08:07, 10 April 2024

OCA at 10:18, 4 August 2021

OCA: Protected "7evw" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 7evw is ON HOLD Authors: Description: Category: Unreleased Structures