7fah - Revision history

OCA at 06:17, 19 July 2023

2023-07-19T06:17:56Z

←Older revision		Revision as of 06:17, 19 July 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[7fah]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus_(A/California/04/2009(H1N1)) Influenza A virus (A/California/04/2009(H1N1))] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7FAH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7FAH FirstGlance]. <br>		<table><tr><td colspan='2'>[[7fah]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus_(A/California/04/2009(H1N1)) Influenza A virus (A/California/04/2009(H1N1))] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7FAH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7FAH FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.151Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7fah FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7fah OCA], [https://pdbe.org/7fah PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7fah RCSB], [https://www.ebi.ac.uk/pdbsum/7fah PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7fah ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7fah FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7fah OCA], [https://pdbe.org/7fah PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7fah RCSB], [https://www.ebi.ac.uk/pdbsum/7fah PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7fah ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/C3W5S1_I09A0 C3W5S1_I09A0]] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore (By similarity).[SAAS:SAAS013829_004_327643][RuleBase:RU003324]	+	[https://www.uniprot.org/uniprot/C3W5S1_I09A0 C3W5S1_I09A0] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore (By similarity).[SAAS:SAAS013829_004_327643][RuleBase:RU003324]
		+
		+	==See Also==
		+	*[[Antibody 3D structures\|Antibody 3D structures]]
		+	*[[Hemagglutinin 3D structures\|Hemagglutinin 3D structures]]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 06:37, 8 September 2022

2022-09-08T06:37:55Z

←Older revision		Revision as of 06:37, 8 September 2022
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-	====	+	==Immune complex of head region of CA09 HA and neutralizing antibody 12H5==
-	<StructureSection load='7fah' size='340' side='right'caption='[[7fah]]' scene=''>	+	<StructureSection load='7fah' size='340' side='right'caption='[[7fah]], [[Resolution\|resolution]] 3.15Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7fah]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus_(A/California/04/2009(H1N1)) Influenza A virus (A/California/04/2009(H1N1))] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7FAH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7FAH FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7fah FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7fah OCA], [https://pdbe.org/7fah PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7fah RCSB], [https://www.ebi.ac.uk/pdbsum/7fah PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7fah ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7fah FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7fah OCA], [https://pdbe.org/7fah PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7fah RCSB], [https://www.ebi.ac.uk/pdbsum/7fah PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7fah ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[https://www.uniprot.org/uniprot/C3W5S1_I09A0 C3W5S1_I09A0]] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore (By similarity).[SAAS:SAAS013829_004_327643][RuleBase:RU003324]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Z-disk~~]]	+	[[Category: Mus musculus]]
		+	[[Category: Gu Y]]
		+	[[Category: Li SW]]
		+	[[Category: Li TT]]
		+	[[Category: Xue WH]]

OCA at 16:10, 6 July 2022

2022-07-06T16:10:59Z

←Older revision		Revision as of 16:10, 6 July 2022
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 7fah ~~is ON HOLD until Paper Publication~~	+	====
-		+	<StructureSection load='7fah' size='340' side='right'caption='[[7fah]]' scene=''>
-	~~Authors~~: ~~Li, T~~.T.~~, Xue, W~~.H.~~, Gu, Y~~.~~, Li, S~~.W.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	~~Description~~: ~~Immune complex of head region of CA09 HA and neutralizing antibody 12H5~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7fah FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7fah OCA], [https://pdbe.org/7fah PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7fah RCSB], [https://www.ebi.ac.uk/pdbsum/7fah PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7fah ProSAT]</span></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	</table>
-	[~~[Category~~: Li, S.W]]	+	__TOC__
-	[~~[Category~~: ~~Xue, W~~.H]]	+	</StructureSection>
-	[[Category: ~~Li, T.T~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Gu, Y~~]]	+	[[Category: Z-disk]]

OCA at 11:40, 29 December 2021

2021-12-29T11:40:53Z

←Older revision		Revision as of 11:40, 29 December 2021
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7fah is ON HOLD	+	The entry 7fah is ON HOLD until Paper Publication

	Authors: Li, T.T., Xue, W.H., Gu, Y., Li, S.W.		Authors: Li, T.T., Xue, W.H., Gu, Y., Li, S.W.
Line 7:		Line 7:
	Description: Immune complex of head region of CA09 HA and neutralizing antibody 12H5		Description: Immune complex of head region of CA09 HA and neutralizing antibody 12H5
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Xue, W.H]]
-	[[Category: Gu, Y]]
	[[Category: Li, S.W]]		[[Category: Li, S.W]]
		+	[[Category: Xue, W.H]]
	[[Category: Li, T.T]]		[[Category: Li, T.T]]
		+	[[Category: Gu, Y]]

OCA at 09:18, 28 July 2021

2021-07-28T09:18:39Z

←Older revision		Revision as of 09:18, 28 July 2021
Line 5:		Line 5:
	Authors: Li, T.T., Xue, W.H., Gu, Y., Li, S.W.		Authors: Li, T.T., Xue, W.H., Gu, Y., Li, S.W.

-	Description: ~~immune~~ complex of head region of CA09 HA and neutralizing antibody 12H5	+	Description: Immune complex of head region of CA09 HA and neutralizing antibody 12H5
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Xue, W.H]]		[[Category: Xue, W.H]]

OCA: Protected "7fah" [edit=sysop:move=sysop]

2021-07-14T08:42:43Z

Protected "7fah" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:42, 14 July 2021

OCA: New page: '''Unreleased structure''' The entry 7fah is ON HOLD Authors: Li, T.T., Xue, W.H., Gu, Y., Li, S.W. Description: immune complex of head region of CA09 HA and neutralizing antibody 12H5...

2021-07-14T08:42:43Z

New page: '''Unreleased structure''' The entry 7fah is ON HOLD Authors: Li, T.T., Xue, W.H., Gu, Y., Li, S.W. Description: immune complex of head region of CA09 HA and neutralizing antibody 12H5...

New page

'''Unreleased structure'''

The entry 7fah is ON HOLD

Authors: Li, T.T., Xue, W.H., Gu, Y., Li, S.W.

Description: immune complex of head region of CA09 HA and neutralizing antibody 12H5
[[Category: Unreleased Structures]]
[[Category: Xue, W.H]]
[[Category: Gu, Y]]
[[Category: Li, S.W]]
[[Category: Li, T.T]]