7fat - Revision history

OCA at 17:12, 29 November 2023

2023-11-29T17:12:24Z

←Older revision		Revision as of 17:12, 29 November 2023
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-	====	+	==Structure Determination of the RBD-NB1A7==
-	<StructureSection load='7fat' size='340' side='right'caption='[[7fat]]' scene=''>	+	<StructureSection load='7fat' size='340' side='right'caption='[[7fat]], [[Resolution\|resolution]] 1.99Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7fat]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Camelus_bactrianus Camelus bactrianus] and [https://en.wikipedia.org/wiki/Severe_acute_respiratory_syndrome_coronavirus_2 Severe acute respiratory syndrome coronavirus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7FAT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7FAT FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7fat FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7fat OCA], [https://pdbe.org/7fat PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7fat RCSB], [https://www.ebi.ac.uk/pdbsum/7fat PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7fat ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.99Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7fat FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7fat OCA], [https://pdbe.org/7fat PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7fat RCSB], [https://www.ebi.ac.uk/pdbsum/7fat PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7fat ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/SPIKE_SARS2 SPIKE_SARS2] attaches the virion to the cell membrane by interacting with host receptor, initiating the infection (By similarity). Binding to human ACE2 receptor and internalization of the virus into the endosomes of the host cell induces conformational changes in the Spike glycoprotein (PubMed:32142651, PubMed:32075877, PubMed:32155444). Uses also human TMPRSS2 for priming in human lung cells which is an essential step for viral entry (PubMed:32142651). Proteolysis by cathepsin CTSL may unmask the fusion peptide of S2 and activate membranes fusion within endosomes.[HAMAP-Rule:MF_04099]<ref>PMID:32075877</ref> <ref>PMID:32142651</ref> <ref>PMID:32155444</ref> mediates fusion of the virion and cellular membranes by acting as a class I viral fusion protein. Under the current model, the protein has at least three conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.[HAMAP-Rule:MF_04099] Acts as a viral fusion peptide which is unmasked following S2 cleavage occurring upon virus endocytosis.[HAMAP-Rule:MF_04099]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Camelus bactrianus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Z-disk~~]]	+	[[Category: Severe acute respiratory syndrome coronavirus 2]]
		+	[[Category: Chen XC]]
		+	[[Category: Geng Y]]
		+	[[Category: Li XY]]
		+	[[Category: Shi ZZ]]
		+	[[Category: Sun ZC]]
		+	[[Category: Wang L]]
		+	[[Category: Zhang HW]]

OCA at 10:14, 18 May 2022

2022-05-18T10:14:23Z

←Older revision		Revision as of 10:14, 18 May 2022
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-	'''Unreleased structure'''

-	~~The entry~~ 7fat ~~is ON HOLD until Paper Publication~~	+	====
-		+	<StructureSection load='7fat' size='340' side='right'caption='[[7fat]]' scene=''>
-	~~Authors~~: ~~Geng, Y~~.~~, Shi, Z~~.Z.~~, Li, X~~.Y.~~, Wang, L~~.~~, Sun, Z~~.C., ~~Zhang, H~~.W.~~, Chen, X~~.C.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	~~Description: Structure Determination of the RBD~~-~~NB1A7~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7fat FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7fat OCA], [https://pdbe.org/7fat PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7fat RCSB], [https://www.ebi.ac.uk/pdbsum/7fat PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7fat ProSAT]</span></td></tr>
-	~~[[Category: Unreleased Structures~~]]	+	</table>
-	[~~[Category~~: ~~Sun, Z~~.C]]	+	__TOC__
-	[~~[Category~~: ~~Chen, X~~.C]]	+	</StructureSection>
-	[~~[Category~~: ~~Zhang, H~~.W]]	+	[[Category: Large Structures]]
-	~~[[Category: Wang~~, ~~L]]~~	+	[[Category: Z-disk]]
-	[~~[Category~~: ~~Li, X~~.Y]]	+
-	[[Category: ~~Shi, Z.Z~~]]	+
-	[[Category: ~~Geng, Y~~]]	+

OCA at 11:41, 29 December 2021

2021-12-29T11:41:01Z

←Older revision		Revision as of 11:41, 29 December 2021
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7fat is ON HOLD	+	The entry 7fat is ON HOLD until Paper Publication

	Authors: Geng, Y., Shi, Z.Z., Li, X.Y., Wang, L., Sun, Z.C., Zhang, H.W., Chen, X.C.		Authors: Geng, Y., Shi, Z.Z., Li, X.Y., Wang, L., Sun, Z.C., Zhang, H.W., Chen, X.C.

OCA at 07:22, 8 September 2021

2021-09-08T07:22:08Z

←Older revision		Revision as of 07:22, 8 September 2021
Line 3:		Line 3:
	The entry 7fat is ON HOLD		The entry 7fat is ON HOLD

-	Authors: Geng, Y.	+	Authors: Geng, Y., Shi, Z.Z., Li, X.Y., Wang, L., Sun, Z.C., Zhang, H.W., Chen, X.C.

	Description: Structure Determination of the RBD-NB1A7		Description: Structure Determination of the RBD-NB1A7
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
		+	[[Category: Sun, Z.C]]
		+	[[Category: Chen, X.C]]
		+	[[Category: Zhang, H.W]]
		+	[[Category: Wang, L]]
		+	[[Category: Li, X.Y]]
		+	[[Category: Shi, Z.Z]]
	[[Category: Geng, Y]]		[[Category: Geng, Y]]

OCA: Protected "7fat" [edit=sysop:move=sysop]

2021-07-14T08:43:17Z

Protected "7fat" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:43, 14 July 2021

OCA: New page: '''Unreleased structure''' The entry 7fat is ON HOLD Authors: Geng, Y. Description: Structure Determination of the RBD-NB1A7 Category: Unreleased Structures Category: Geng, Y

2021-07-14T08:43:16Z

New page: '''Unreleased structure''' The entry 7fat is ON HOLD Authors: Geng, Y. Description: Structure Determination of the RBD-NB1A7 Category: Unreleased Structures Category: Geng, Y

New page

'''Unreleased structure'''

The entry 7fat is ON HOLD

Authors: Geng, Y.

Description: Structure Determination of the RBD-NB1A7
[[Category: Unreleased Structures]]
[[Category: Geng, Y]]