7jh1 - Revision history

OCA at 11:13, 14 June 2023

2023-06-14T11:13:26Z

←Older revision		Revision as of 11:13, 14 June 2023
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	==Solution structure of a reconstructed XCL1 ancestor==		==Solution structure of a reconstructed XCL1 ancestor==
-	<StructureSection load='7jh1' size='340' side='right'caption='[[7jh1~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='7jh1' size='340' side='right'caption='[[7jh1]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[7jh1]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Miscellaneous_nucleic_acid Miscellaneous nucleic acid~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7JH1 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=7JH1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7jh1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7JH1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7JH1 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=7jh1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7jh1 OCA], [~~http~~://pdbe.org/7jh1 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=7jh1 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/7jh1 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=7jh1 ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7jh1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7jh1 OCA], [https://pdbe.org/7jh1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7jh1 RCSB], [https://www.ebi.ac.uk/pdbsum/7jh1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7jh1 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 20:		Line 20:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Miscellaneous nucleic acid~~]]	+	[[Category: Synthetic construct]]
-	[[Category: Peterson~~, F C~~]]	+	[[Category: Peterson FC]]
-	[[Category: Tyler~~, R C~~]]	+	[[Category: Tyler RC]]
-	[[Category: Volkman~~, B F]]~~	+	[[Category: Volkman BF]]
-	~~[[Category: Ancestral reconstruction]]~~	+
-	~~[[Category: Chemokine]]~~	+
-	~~[[Category: Cytokine]]~~	+
-	~~[[Category: Metamorphic protein~~]]	+

OCA at 06:05, 20 January 2021

2021-01-20T06:05:28Z

←Older revision		Revision as of 06:05, 20 January 2021
Line 1:		Line 1:

	==Solution structure of a reconstructed XCL1 ancestor==		==Solution structure of a reconstructed XCL1 ancestor==
-	<StructureSection load='7jh1' size='340' side='right'caption='[[7jh1]]' scene=''>	+	<StructureSection load='7jh1' size='340' side='right'caption='[[7jh1]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7JH1 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=7JH1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7jh1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Miscellaneous_nucleic_acid Miscellaneous nucleic acid]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7JH1 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=7JH1 FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=7jh1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7jh1 OCA], [http://pdbe.org/7jh1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=7jh1 RCSB], [http://www.ebi.ac.uk/pdbsum/7jh1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=7jh1 ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=7jh1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7jh1 OCA], [http://pdbe.org/7jh1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=7jh1 RCSB], [http://www.ebi.ac.uk/pdbsum/7jh1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=7jh1 ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Metamorphic proteins switch between different folds, defying the protein folding paradigm. It is unclear how fold switching arises during evolution. With ancestral reconstruction and nuclear magnetic resonance, we studied the evolution of the metamorphic human protein XCL1, which has two distinct folds with different functions, making it an unusual member of the chemokine family, whose members generally adopt one conserved fold. XCL1 evolved from an ancestor with the chemokine fold. Evolution of a dimer interface, changes in structural constraints and molecular strain, and alteration of intramolecular protein contacts drove the evolution of metamorphosis. Then, XCL1 likely evolved to preferentially populate the noncanonical fold before reaching its modern-day near-equal population of folds. These discoveries illuminate how one sequence has evolved to encode multiple structures, revealing principles for protein design and engineering.
		+
		+	Evolution of fold switching in a metamorphic protein.,Dishman AF, Tyler RC, Fox JC, Kleist AB, Prehoda KE, Babu MM, Peterson FC, Volkman BF Science. 2021 Jan 1;371(6524):86-90. doi: 10.1126/science.abd8700. PMID:33384377<ref>PMID:33384377</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7jh1" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Peterson FC]]	+	[[Category: Miscellaneous nucleic acid]]
-	[[Category: Tyler RC]]	+	[[Category: Peterson, F C]]
-	[[Category: Volkman BF]]	+	[[Category: Tyler, R C]]
		+	[[Category: Volkman, B F]]
		+	[[Category: Ancestral reconstruction]]
		+	[[Category: Chemokine]]
		+	[[Category: Cytokine]]
		+	[[Category: Metamorphic protein]]

OCA at 06:49, 30 December 2020

2020-12-30T06:49:17Z

←Older revision		Revision as of 06:49, 30 December 2020
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 7jh1 ~~is ON HOLD until Paper Publication~~	+	==Solution structure of a reconstructed XCL1 ancestor==
-		+	<StructureSection load='7jh1' size='340' side='right'caption='[[7jh1]]' scene=''>
-	~~Authors~~: ~~Tyler~~, R.C., ~~Peterson~~, F.C., ~~Volkman~~, B.F.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7JH1 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=7JH1 FirstGlance]. <br>
-	~~Description: Solution structure of a reconstructed XCL1 ancestor~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=7jh1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7jh1 OCA], [http://pdbe.org/7jh1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=7jh1 RCSB], [http://www.ebi.ac.uk/pdbsum/7jh1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=7jh1 ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
-	[[Category: Peterson~~, F.C~~]]	+	__TOC__
-	[[Category: ~~Volkman, B.F~~]]	+	</StructureSection>
-	[[Category: ~~Tyler, R.C~~]]	+	[[Category: Large Structures]]
		+	[[Category: Peterson FC]]
		+	[[Category: Tyler RC]]
		+	[[Category: Volkman BF]]

OCA: Protected "7jh1" [edit=sysop:move=sysop]

2020-07-29T09:48:15Z

Protected "7jh1" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:48, 29 July 2020

OCA: New page: '''Unreleased structure''' The entry 7jh1 is ON HOLD until Paper Publication Authors: Tyler, R.C., Peterson, F.C., Volkman, B.F. Description: Solution structure of a reconstructed XCL1...

2020-07-29T09:48:13Z

New page: '''Unreleased structure''' The entry 7jh1 is ON HOLD until Paper Publication Authors: Tyler, R.C., Peterson, F.C., Volkman, B.F. Description: Solution structure of a reconstructed XCL1...

New page

'''Unreleased structure'''

The entry 7jh1 is ON HOLD until Paper Publication

Authors: Tyler, R.C., Peterson, F.C., Volkman, B.F.

Description: Solution structure of a reconstructed XCL1 ancestor
[[Category: Unreleased Structures]]
[[Category: Peterson, F.C]]
[[Category: Volkman, B.F]]
[[Category: Tyler, R.C]]