OCA at 14:52, 6 March 2024

2024-03-06T14:52:25Z

←Older revision		Revision as of 14:52, 6 March 2024
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-	====	+	==HUMAN PI3KDELTA IN COMPLEX WITH COMPOUND 2F==
-	<StructureSection load='7jis' size='340' side='right'caption='[[7jis]]' scene=''>	+	<StructureSection load='7jis' size='340' side='right'caption='[[7jis]], [[Resolution\|resolution]] 2.42Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7jis]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7JIS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7JIS FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=7jis FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7jis OCA], [~~http~~://pdbe.org/7jis PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=7jis RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/7jis PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=7jis ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.42Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=VBS:(3S)-3-benzyl-5-[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]-3-methyl-1,3-dihydro-2H-indol-2-one'>VBS</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7jis FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7jis OCA], [https://pdbe.org/7jis PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7jis RCSB], [https://www.ebi.ac.uk/pdbsum/7jis PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7jis ProSAT]</span></td></tr>
	</table>		</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/PK3CD_HUMAN PK3CD_HUMAN] Activated PIK3-delta syndrome. The disease is caused by mutations affecting the gene represented in this entry.
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/PK3CD_HUMAN PK3CD_HUMAN] Phosphoinositide-3-kinase (PI3K) that phosphorylates PftdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Mediates immune responses. Plays a role in B-cell development, proliferation, migration, and function. Required for B-cell receptor (BCR) signaling. Mediates B-cell proliferation response to anti-IgM, anti-CD40 and IL4 stimulation. Promotes cytokine production in response to TLR4 and TLR9. Required for antibody class switch mediated by TLR9. Involved in the antigen presentation function of B-cells. Involved in B-cell chemotaxis in response to CXCL13 and sphingosine 1-phosphate (S1P). Required for proliferation, signaling and cytokine production of naive, effector and memory T-cells. Required for T-cell receptor (TCR) signaling. Mediates TCR signaling events at the immune synapse. Activation by TCR leads to antigen-dependent memory T-cell migration and retention to antigenic tissues. Together with PIK3CG participates in T-cell development. Contributes to T-helper cell expansion and differentiation. Required for T-cell migration mediated by homing receptors SELL/CD62L, CCR7 and S1PR1 and antigen dependent recruitment of T-cells. Together with PIK3CG is involved in natural killer (NK) cell development and migration towards the sites of inflammation. Participates in NK cell receptor activation. Have a role in NK cell maturation and cytokine production. Together with PIK3CG is involved in neutrophil chemotaxis and extravasation. Together with PIK3CG participates in neutrophil respiratory burst. Have important roles in mast-cell development and mast cell mediated allergic response. Involved in stem cell factor (SCF)-mediated proliferation, adhesion and migration. Required for allergen-IgE-induced degranulation and cytokine release. The lipid kinase activity is required for its biological function. Isoform 2 may be involved in stabilizing total RAS levels, resulting in increased ERK phosphorylation and increased PI3K activity.<ref>PMID:20081091</ref> <ref>PMID:22020336</ref>
		+
		+	==See Also==
		+	*[[Phosphoinositide 3-kinase 3D structures\|Phosphoinositide 3-kinase 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Bos taurus]]
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Z-disk~~]]	+	[[Category: Augustin M]]
		+	[[Category: Lesburg CA]]

OCA at 06:49, 30 December 2020

2020-12-30T06:49:18Z

←Older revision		Revision as of 06:49, 30 December 2020
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-	'''Unreleased structure'''

-	~~The entry~~ 7jis ~~is ON HOLD until Paper Publication~~	+	====
-		+	<StructureSection load='7jis' size='340' side='right'caption='[[7jis]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=7jis FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7jis OCA], [http://pdbe.org/7jis PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=7jis RCSB], [http://www.ebi.ac.uk/pdbsum/7jis PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=7jis ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Z-disk]]

OCA at 09:33, 26 August 2020

2020-08-26T09:33:18Z

←Older revision		Revision as of 09:33, 26 August 2020
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7jis is ON HOLD	+	The entry 7jis is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7jis" [edit=sysop:move=sysop]

2020-07-29T09:53:14Z

Protected "7jis" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:53, 29 July 2020

OCA: New page: '''Unreleased structure''' The entry 7jis is ON HOLD Authors: Description: Category: Unreleased Structures

2020-07-29T09:53:13Z

New page: '''Unreleased structure''' The entry 7jis is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7jis is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

7jis - Revision history

OCA at 14:52, 6 March 2024

OCA at 06:49, 30 December 2020

OCA at 09:33, 26 August 2020

OCA: Protected "7jis" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 7jis is ON HOLD Authors: Description: Category: Unreleased Structures