7jl1 - Revision history

OCA at 14:52, 6 March 2024

2024-03-06T14:52:41Z

←Older revision		Revision as of 14:52, 6 March 2024
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-	====	+	==Cryo-EM structure of RIG-I:dsRNA in complex with RIPLET PrySpry domain (monomer)==
-	<StructureSection load='7jl1' size='340' side='right'caption='[[7jl1]]' scene=''>	+	<StructureSection load='7jl1' size='340' side='right'caption='[[7jl1]], [[Resolution\|resolution]] 3.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7jl1]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7JL1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7JL1 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7jl1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7jl1 OCA], [https://pdbe.org/7jl1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7jl1 RCSB], [https://www.ebi.ac.uk/pdbsum/7jl1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7jl1 ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 3.9Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=ALF:TETRAFLUOROALUMINATE+ION'>ALF</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7jl1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7jl1 OCA], [https://pdbe.org/7jl1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7jl1 RCSB], [https://www.ebi.ac.uk/pdbsum/7jl1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7jl1 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/RIGI_HUMAN RIGI_HUMAN] Singleton-Merten dysplasia. The disease is caused by variants affecting the gene represented in this entry.
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/RIGI_HUMAN RIGI_HUMAN] Innate immune receptor that senses cytoplasmic viral nucleic acids and activates a downstream signaling cascade leading to the production of type I interferons and pro-inflammatory cytokines (PubMed:15208624, PubMed:16125763, PubMed:15708988, PubMed:16127453, PubMed:16153868, PubMed:17190814, PubMed:18636086, PubMed:19122199, PubMed:19211564, PubMed:29117565, PubMed:28469175, PubMed:31006531, PubMed:34935440). Forms a ribonucleoprotein complex with viral RNAs on which it homooligomerizes to form filaments (PubMed:15208624, PubMed:15708988). The homooligomerization allows the recruitment of RNF135 an E3 ubiquitin-protein ligase that activates and amplifies the RIG-I-mediated antiviral signaling in an RNA length-dependent manner through ubiquitination-dependent and -independent mechanisms (PubMed:28469175, PubMed:31006531). Upon activation, associates with mitochondria antiviral signaling protein (MAVS/IPS1) that activates the IKK-related kinases TBK1 and IKBKE which in turn phosphorylate the interferon regulatory factors IRF3 and IRF7, activating transcription of antiviral immunological genes including the IFN-alpha and IFN-beta interferons (PubMed:28469175, PubMed:31006531). Ligands include 5'-triphosphorylated ssRNAs and dsRNAs but also short dsRNAs (<1 kb in length) (PubMed:15208624, PubMed:15708988, PubMed:19576794, PubMed:19609254, PubMed:21742966). In addition to the 5'-triphosphate moiety, blunt-end base pairing at the 5'-end of the RNA is very essential (PubMed:15208624, PubMed:15708988, PubMed:19576794, PubMed:19609254, PubMed:21742966). Overhangs at the non-triphosphorylated end of the dsRNA RNA have no major impact on its activity (PubMed:15208624, PubMed:15708988, PubMed:19576794, PubMed:19609254, PubMed:21742966). A 3'overhang at the 5'triphosphate end decreases and any 5'overhang at the 5' triphosphate end abolishes its activity (PubMed:15208624, PubMed:15708988, PubMed:19576794, PubMed:19609254, PubMed:21742966). Detects both positive and negative strand RNA viruses including members of the families Paramyxoviridae: Human respiratory syncytial virus and measles virus (MeV), Rhabdoviridae: vesicular stomatitis virus (VSV), Orthomyxoviridae: influenza A and B virus, Flaviviridae: Japanese encephalitis virus (JEV), hepatitis C virus (HCV), dengue virus (DENV) and west Nile virus (WNV) (PubMed:21616437, PubMed:21884169). It also detects rotaviruses and reoviruses (PubMed:21616437, PubMed:21884169). Detects and binds to SARS-CoV-2 RNAs which is inhibited by m6A RNA modifications (Ref.66). Also involved in antiviral signaling in response to viruses containing a dsDNA genome such as Epstein-Barr virus (EBV) (PubMed:19631370). Detects dsRNA produced from non-self dsDNA by RNA polymerase III, such as Epstein-Barr virus-encoded RNAs (EBERs). May play important roles in granulocyte production and differentiation, bacterial phagocytosis and in the regulation of cell migration.<ref>PMID:15208624</ref> <ref>PMID:15708988</ref> <ref>PMID:16125763</ref> <ref>PMID:16127453</ref> <ref>PMID:16153868</ref> <ref>PMID:17190814</ref> <ref>PMID:18636086</ref> <ref>PMID:19122199</ref> <ref>PMID:19211564</ref> <ref>PMID:19576794</ref> <ref>PMID:19609254</ref> <ref>PMID:19631370</ref> <ref>PMID:21742966</ref> <ref>PMID:28469175</ref> <ref>PMID:29117565</ref> <ref>PMID:31006531</ref> <ref>PMID:34935440</ref> <ref>PMID:17974005</ref> <ref>PMID:21616437</ref> <ref>PMID:21884169</ref>
		+
		+	==See Also==
		+	*[[Ubiquitin protein ligase 3D structures\|Ubiquitin protein ligase 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Z-disk~~]]	+	[[Category: Ahmad S]]
		+	[[Category: Hur S]]
		+	[[Category: Kato K]]

OCA at 10:05, 17 February 2021

2021-02-17T10:05:35Z

←Older revision		Revision as of 10:05, 17 February 2021
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	<StructureSection load='7jl1' size='340' side='right'caption='[[7jl1]]' scene=''>		<StructureSection load='7jl1' size='340' side='right'caption='[[7jl1]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=7jl1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7jl1 OCA], [~~http~~://pdbe.org/7jl1 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=7jl1 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/7jl1 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=7jl1 ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7jl1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7jl1 OCA], [https://pdbe.org/7jl1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7jl1 RCSB], [https://www.ebi.ac.uk/pdbsum/7jl1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7jl1 ProSAT]</span></td></tr>
	</table>		</table>
	__TOC__		__TOC__

OCA at 06:41, 9 December 2020

2020-12-09T06:41:33Z

←Older revision		Revision as of 06:41, 9 December 2020
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-	'''Unreleased structure'''

-	~~The entry~~ 7jl1 ~~is ON HOLD until Paper Publication~~	+	====
-		+	<StructureSection load='7jl1' size='340' side='right'caption='[[7jl1]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=7jl1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7jl1 OCA], [http://pdbe.org/7jl1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=7jl1 RCSB], [http://www.ebi.ac.uk/pdbsum/7jl1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=7jl1 ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Z-disk]]

OCA at 05:20, 2 September 2020

2020-09-02T05:20:05Z

←Older revision		Revision as of 05:20, 2 September 2020
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7jl1 is ON HOLD	+	The entry 7jl1 is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7jl1" [edit=sysop:move=sysop]

2020-08-05T04:18:43Z

Protected "7jl1" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:18, 5 August 2020

OCA: New page: '''Unreleased structure''' The entry 7jl1 is ON HOLD Authors: Description: Category: Unreleased Structures

2020-08-05T04:18:41Z

New page: '''Unreleased structure''' The entry 7jl1 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7jl1 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]