7jlx - Revision history

OCA at 14:52, 6 March 2024

2024-03-06T14:52:51Z

←Older revision		Revision as of 14:52, 6 March 2024
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	<StructureSection load='7jlx' size='340' side='right'caption='[[7jlx]], [[Resolution\|resolution]] 4.60Å' scene=''>		<StructureSection load='7jlx' size='340' side='right'caption='[[7jlx]], [[Resolution\|resolution]] 4.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[7jlx]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Nicbe Nicbe~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7JLX OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=7JLX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7jlx]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Nicotiana_benthamiana Nicotiana benthamiana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7JLX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7JLX FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>ROQ1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id~~=4100 NICBE])</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 4.6Å</td></tr>
-	~~<tr id='activity'><td class~~="~~sblockLbl~~">~~<b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>~~[~~http://en.wikipedia.org/wiki/ADP-ribosyl_cyclase/cyclic_ADP-ribose_hydrolase ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase~~]~~, with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2~~.6 ~~3.2.2.6] </span>~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7jlx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7jlx OCA], [https://pdbe.org/7jlx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7jlx RCSB], [https://www.ebi.ac.uk/pdbsum/7jlx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7jlx ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=7jlx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7jlx OCA], [~~http~~://pdbe.org/7jlx PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=7jlx RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/7jlx PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=7jlx ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/ROQ1_NICBE ROQ1_NICBE]] Disease resistance (R) protein that specifically recognizes the Xanthomonas and Pseudomonas effector proteins XopQ and HopQ1, and triggers cell death (PubMed:28891100). Acts as a NAD(+) hydrolase (NADase): in response to activation, catalyzes cleavage of NAD(+) into ADP-D-ribose (ADPR) and nicotinamide; NAD(+) cleavage triggering a defense system that promotes cell death (PubMed:31439792).<ref>PMID:28891100</ref> <ref>PMID:31439792</ref>	+	[https://www.uniprot.org/uniprot/ROQ1_NICBE ROQ1_NICBE] Disease resistance (R) protein that specifically recognizes the Xanthomonas and Pseudomonas effector proteins XopQ and HopQ1, and triggers cell death (PubMed:28891100). Acts as a NAD(+) hydrolase (NADase): in response to activation, catalyzes cleavage of NAD(+) into ADP-D-ribose (ADPR) and nicotinamide; NAD(+) cleavage triggering a defense system that promotes cell death (PubMed:31439792).<ref>PMID:28891100</ref> <ref>PMID:31439792</ref>
-	~~<div style="background-color:#fffaf0;">~~	+
-	~~== Publication Abstract from PubMed ==~~	+
-	Plants and animals detect pathogen infection using intracellular nucleotide-binding leucine-rich repeat receptors (NLRs) that directly or indirectly recognize pathogen effectors and activate an immune response. How effector sensing triggers NLR activation remains poorly understood. Here we describe the 3.8-angstrom-resolution cryo-electron microscopy structure of the activated ROQ1 (recognition of XopQ 1), an NLR native to Nicotiana benthamiana with a Toll-like interleukin-1 receptor (TIR) domain bound to the Xanthomonas euvesicatoria effector XopQ (Xanthomonas outer protein Q). ROQ1 directly binds to both the predicted active site and surface residues of XopQ while forming a tetrameric resistosome that brings together the TIR domains for downstream immune signaling. Our results suggest a mechanism for the direct recognition of effectors by NLRs leading to the oligomerization-dependent activation of a plant resistosome and signaling by the TIR domain.	+
-		+
-	Structure of the activated ROQ1 resistosome directly recognizing the pathogen effector XopQ.,Martin R, Qi T, Zhang H, Liu F, King M, Toth C, Nogales E, Staskawicz BJ Science. 2020 Dec 4;370(6521). pii: 370/6521/eabd9993. doi:, 10.1126/science.abd9993. PMID:33273074<ref>PMID:33273074</ref>	+
-		+
-	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~	+
-	~~</div>~~	+
-	~~<div class="pdbe-citations 7jlx" style="background-color:#fffaf0;"></div~~>	+
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Nicbe~~]]	+	[[Category: Nicotiana benthamiana]]
-	[[Category: King, M]]	+	[[Category: King M]]
-	[[Category: Lui, F]]	+	[[Category: Lui F]]
-	[[Category: Martin, R]]	+	[[Category: Martin R]]
-	[[Category: Nogales, E]]	+	[[Category: Nogales E]]
-	[[Category: Qi, T]]	+	[[Category: Qi T]]
-	[[Category: Staskawicz~~, B J~~]]	+	[[Category: Staskawicz BJ]]
-	[[Category: Toth, C]]	+	[[Category: Toth C]]
-	[[Category: Zhang, H]]	+	[[Category: Zhang H]]
-	~~[[Category: Effector]]~~	+
-	~~[[Category: Immune system]]~~	+
-	~~[[Category: Lrr]]~~	+
-	~~[[Category: Nb-arc]]~~	+
-	~~[[Category: Pl]]~~	+
-	~~[[Category: Plant immunity]]~~	+
-	~~[[Category: Resistosome]]~~	+
-	~~[[Category: Tir~~]]	+

OCA at 13:01, 16 December 2020

2020-12-16T13:01:00Z

←Older revision		Revision as of 13:01, 16 December 2020
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	==Structure of the activated Roq1 resistosome directly recognizing the pathogen effector XopQ (TIR domains)==		==Structure of the activated Roq1 resistosome directly recognizing the pathogen effector XopQ (TIR domains)==
-	<StructureSection load='7jlx' size='340' side='right'caption='[[7jlx]]' scene=''>	+	<StructureSection load='7jlx' size='340' side='right'caption='[[7jlx]], [[Resolution\|resolution]] 4.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7JLX OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=7JLX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7jlx]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Nicbe Nicbe]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7JLX OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=7JLX FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=7jlx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7jlx OCA], [http://pdbe.org/7jlx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=7jlx RCSB], [http://www.ebi.ac.uk/pdbsum/7jlx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=7jlx ProSAT]</span></td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ROQ1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4100 NICBE])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/ADP-ribosyl_cyclase/cyclic_ADP-ribose_hydrolase ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.6 3.2.2.6] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=7jlx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7jlx OCA], [http://pdbe.org/7jlx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=7jlx RCSB], [http://www.ebi.ac.uk/pdbsum/7jlx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=7jlx ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ROQ1_NICBE ROQ1_NICBE]] Disease resistance (R) protein that specifically recognizes the Xanthomonas and Pseudomonas effector proteins XopQ and HopQ1, and triggers cell death (PubMed:28891100). Acts as a NAD(+) hydrolase (NADase): in response to activation, catalyzes cleavage of NAD(+) into ADP-D-ribose (ADPR) and nicotinamide; NAD(+) cleavage triggering a defense system that promotes cell death (PubMed:31439792).<ref>PMID:28891100</ref> <ref>PMID:31439792</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Plants and animals detect pathogen infection using intracellular nucleotide-binding leucine-rich repeat receptors (NLRs) that directly or indirectly recognize pathogen effectors and activate an immune response. How effector sensing triggers NLR activation remains poorly understood. Here we describe the 3.8-angstrom-resolution cryo-electron microscopy structure of the activated ROQ1 (recognition of XopQ 1), an NLR native to Nicotiana benthamiana with a Toll-like interleukin-1 receptor (TIR) domain bound to the Xanthomonas euvesicatoria effector XopQ (Xanthomonas outer protein Q). ROQ1 directly binds to both the predicted active site and surface residues of XopQ while forming a tetrameric resistosome that brings together the TIR domains for downstream immune signaling. Our results suggest a mechanism for the direct recognition of effectors by NLRs leading to the oligomerization-dependent activation of a plant resistosome and signaling by the TIR domain.
		+
		+	Structure of the activated ROQ1 resistosome directly recognizing the pathogen effector XopQ.,Martin R, Qi T, Zhang H, Liu F, King M, Toth C, Nogales E, Staskawicz BJ Science. 2020 Dec 4;370(6521). pii: 370/6521/eabd9993. doi:, 10.1126/science.abd9993. PMID:33273074<ref>PMID:33273074</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7jlx" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: King M]]	+	[[Category: Nicbe]]
-	[[Category: Lui F]]	+	[[Category: King, M]]
-	[[Category: Martin R]]	+	[[Category: Lui, F]]
-	[[Category: Nogales E]]	+	[[Category: Martin, R]]
-	[[Category: Qi T]]	+	[[Category: Nogales, E]]
-	[[Category: Staskawicz BJ]]	+	[[Category: Qi, T]]
-	[[Category: Toth C]]	+	[[Category: Staskawicz, B J]]
-	[[Category: Zhang H]]	+	[[Category: Toth, C]]
		+	[[Category: Zhang, H]]
		+	[[Category: Effector]]
		+	[[Category: Immune system]]
		+	[[Category: Lrr]]
		+	[[Category: Nb-arc]]
		+	[[Category: Pl]]
		+	[[Category: Plant immunity]]
		+	[[Category: Resistosome]]
		+	[[Category: Tir]]

OCA at 07:55, 2 December 2020

2020-12-02T07:55:34Z

←Older revision		Revision as of 07:55, 2 December 2020
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-	'''Unreleased structure'''

-	~~The entry~~ 7jlx is ~~ON HOLD until Paper Publication~~	+	==Structure of the activated Roq1 resistosome directly recognizing the pathogen effector XopQ (TIR domains)==
-		+	<StructureSection load='7jlx' size='340' side='right'caption='[[7jlx]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7JLX OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=7JLX FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=7jlx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7jlx OCA], [http://pdbe.org/7jlx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=7jlx RCSB], [http://www.ebi.ac.uk/pdbsum/7jlx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=7jlx ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: King M]]
		+	[[Category: Lui F]]
		+	[[Category: Martin R]]
		+	[[Category: Nogales E]]
		+	[[Category: Qi T]]
		+	[[Category: Staskawicz BJ]]
		+	[[Category: Toth C]]
		+	[[Category: Zhang H]]

OCA at 08:05, 18 November 2020

2020-11-18T08:05:12Z

←Older revision		Revision as of 08:05, 18 November 2020
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7jlx is ON HOLD	+	The entry 7jlx is ON HOLD until Paper Publication

	Authors:		Authors:

OCA at 06:48, 21 October 2020

2020-10-21T06:48:13Z

←Older revision		Revision as of 06:48, 21 October 2020
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7jlx is ON HOLD ~~until Paper Publication~~	+	The entry 7jlx is ON HOLD

	Authors:		Authors:

OCA at 05:20, 2 September 2020

2020-09-02T05:20:35Z

←Older revision		Revision as of 05:20, 2 September 2020
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7jlx is ON HOLD	+	The entry 7jlx is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7jlx" [edit=sysop:move=sysop]

2020-08-05T04:21:14Z

Protected "7jlx" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:21, 5 August 2020

OCA: New page: '''Unreleased structure''' The entry 7jlx is ON HOLD Authors: Description: Category: Unreleased Structures

2020-08-05T04:21:13Z

New page: '''Unreleased structure''' The entry 7jlx is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7jlx is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]