7jmx - Revision history

OCA at 15:07, 18 October 2023

2023-10-18T15:07:04Z

←Older revision		Revision as of 15:07, 18 October 2023
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-	====	+	==Crystal structure of a SARS-CoV-2 cross-neutralizing antibody COVA1-16 Fab==
-	<StructureSection load='7jmx' size='340' side='right'caption='[[7jmx]]' scene=''>	+	<StructureSection load='7jmx' size='340' side='right'caption='[[7jmx]], [[Resolution\|resolution]] 2.53Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7jmx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7JMX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7JMX FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7jmx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7jmx OCA], [https://pdbe.org/7jmx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7jmx RCSB], [https://www.ebi.ac.uk/pdbsum/7jmx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7jmx ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.53Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7jmx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7jmx OCA], [https://pdbe.org/7jmx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7jmx RCSB], [https://www.ebi.ac.uk/pdbsum/7jmx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7jmx ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Most antibodies isolated from individuals with coronavirus disease 2019 (COVID-19) are specific to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, COVA1-16 is a relatively rare antibody that also cross-neutralizes SARS-CoV. Here, we determined a crystal structure of the COVA1-16 antibody fragment (Fab) with the SARS-CoV-2 receptor-binding domain (RBD) and negative-stain electron microscopy reconstructions with the spike glycoprotein trimer to elucidate the structural basis of its cross-reactivity. COVA1-16 binds a highly conserved epitope on the SARS-CoV-2 RBD, mainly through a long complementarity-determining region (CDR) H3, and competes with the angiotensin-converting enzyme 2 (ACE2) receptor because of steric hindrance rather than epitope overlap. COVA1-16 binds to a flexible up conformation of the RBD on the spike and relies on antibody avidity for neutralization. These findings, along with the structural and functional rationale for epitope conservation, provide insights for development of more universal SARS-like coronavirus vaccines and therapies.
		+
		+	Cross-Neutralization of a SARS-CoV-2 Antibody to a Functionally Conserved Site Is Mediated by Avidity.,Liu H, Wu NC, Yuan M, Bangaru S, Torres JL, Caniels TG, van Schooten J, Zhu X, Lee CD, Brouwer PJM, van Gils MJ, Sanders RW, Ward AB, Wilson IA Immunity. 2020 Dec 15;53(6):1272-1280.e5. doi: 10.1016/j.immuni.2020.10.023. Epub , 2020 Nov 25. PMID:33242394<ref>PMID:33242394</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7jmx" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Antibody 3D structures\|Antibody 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Z-disk~~]]	+	[[Category: Liu H]]
		+	[[Category: Wilson IA]]
		+	[[Category: Wu NC]]
		+	[[Category: Yuan M]]
		+	[[Category: Zhu X]]

OCA at 07:32, 9 February 2022

2022-02-09T07:32:11Z

←Older revision		Revision as of 07:32, 9 February 2022
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	<StructureSection load='7jmx' size='340' side='right'caption='[[7jmx]]' scene=''>		<StructureSection load='7jmx' size='340' side='right'caption='[[7jmx]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=7jmx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7jmx OCA], [~~http~~://pdbe.org/7jmx PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=7jmx RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/7jmx PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=7jmx ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7jmx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7jmx OCA], [https://pdbe.org/7jmx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7jmx RCSB], [https://www.ebi.ac.uk/pdbsum/7jmx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7jmx ProSAT]</span></td></tr>
	</table>		</table>
	__TOC__		__TOC__

OCA at 05:52, 14 October 2020

2020-10-14T05:52:54Z

←Older revision		Revision as of 05:52, 14 October 2020
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-	'''Unreleased structure'''

-	~~The entry~~ 7jmx ~~is ON HOLD until Paper Publication~~	+	====
-		+	<StructureSection load='7jmx' size='340' side='right'caption='[[7jmx]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=7jmx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7jmx OCA], [http://pdbe.org/7jmx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=7jmx RCSB], [http://www.ebi.ac.uk/pdbsum/7jmx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=7jmx ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Z-disk]]

OCA at 04:48, 19 August 2020

2020-08-19T04:48:46Z

←Older revision		Revision as of 04:48, 19 August 2020
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7jmx is ON HOLD	+	The entry 7jmx is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7jmx" [edit=sysop:move=sysop]

2020-08-12T08:30:55Z

Protected "7jmx" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:30, 12 August 2020

OCA: New page: '''Unreleased structure''' The entry 7jmx is ON HOLD Authors: Description: Category: Unreleased Structures

2020-08-12T08:30:54Z

New page: '''Unreleased structure''' The entry 7jmx is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7jmx is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]