7k02 - Revision history

OCA at 15:15, 18 October 2023

2023-10-18T15:15:23Z

←Older revision		Revision as of 15:15, 18 October 2023
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	<StructureSection load='7k02' size='340' side='right'caption='[[7k02]], [[Resolution\|resolution]] 3.40Å' scene=''>		<StructureSection load='7k02' size='340' side='right'caption='[[7k02]], [[Resolution\|resolution]] 3.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[7k02]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7K02 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7K02 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7k02]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7K02 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7K02 FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[4u2v\|4u2v]]</div></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.4Å</td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Gene~~\|~~Gene:~~]]~~</b></td><td class="sblockDat">BAK1, BAK, BCL2L7, CDN1 ([https://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=9606 HUMAN])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7k02 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7k02 OCA], [https://pdbe.org/7k02 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7k02 RCSB], [https://www.ebi.ac.uk/pdbsum/7k02 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7k02 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7k02 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7k02 OCA], [https://pdbe.org/7k02 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7k02 RCSB], [https://www.ebi.ac.uk/pdbsum/7k02 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7k02 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/BAK_HUMAN BAK_HUMAN]] In the presence of an appropriate stimulus, accelerates programmed cell death by binding to, and antagonizing the anti-apoptotic action of BCL2 or its adenovirus homolog E1B 19k protein. Low micromolar levels of zinc ions inhibit the promotion of apoptosis.<ref>PMID:8521816</ref> <ref>PMID:17157251</ref>	+	[https://www.uniprot.org/uniprot/BAK_HUMAN BAK_HUMAN] In the presence of an appropriate stimulus, accelerates programmed cell death by binding to, and antagonizing the anti-apoptotic action of BCL2 or its adenovirus homolog E1B 19k protein. Low micromolar levels of zinc ions inhibit the promotion of apoptosis.<ref>PMID:8521816</ref> <ref>PMID:17157251</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Birkinshaw~~, R W~~]]	+	[[Category: Birkinshaw RW]]
-	[[Category: Czabotar~~, P E]]~~	+	[[Category: Czabotar PE]]
-	~~[[Category: Apoptosis]]~~	+
-	~~[[Category: Bak]]~~	+
-	~~[[Category: Bcl-2 fold]]~~	+
-	~~[[Category: Bh3-in-groove dimer]]~~	+
-	~~[[Category: Pore forming]]~~	+
-	~~[[Category: Proapoptotic~~]]	+

OCA at 14:50, 2 June 2021

2021-06-02T14:50:36Z

←Older revision		Revision as of 14:50, 2 June 2021
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	</div>		</div>
	<div class="pdbe-citations 7k02" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 7k02" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[B-cell lymphoma proteins 3D structures\|B-cell lymphoma proteins 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 08:33, 21 April 2021

2021-04-21T08:33:53Z

←Older revision		Revision as of 08:33, 21 April 2021
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	==The crystal structure of a BAK dimer activated by detergent==		==The crystal structure of a BAK dimer activated by detergent==
-	<StructureSection load='7k02' size='340' side='right'caption='[[7k02]]' scene=''>	+	<StructureSection load='7k02' size='340' side='right'caption='[[7k02]], [[Resolution\|resolution]] 3.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7K02 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7K02 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7k02]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7K02 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7K02 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7k02 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7k02 OCA], [https://pdbe.org/7k02 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7k02 RCSB], [https://www.ebi.ac.uk/pdbsum/7k02 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7k02 ProSAT]</span></td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[4u2v\|4u2v]]</div></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BAK1, BAK, BCL2L7, CDN1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7k02 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7k02 OCA], [https://pdbe.org/7k02 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7k02 RCSB], [https://www.ebi.ac.uk/pdbsum/7k02 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7k02 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[https://www.uniprot.org/uniprot/BAK_HUMAN BAK_HUMAN]] In the presence of an appropriate stimulus, accelerates programmed cell death by binding to, and antagonizing the anti-apoptotic action of BCL2 or its adenovirus homolog E1B 19k protein. Low micromolar levels of zinc ions inhibit the promotion of apoptosis.<ref>PMID:8521816</ref> <ref>PMID:17157251</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	A body of data supports the existence of core (alpha2-alpha5) dimers of BAK and BAX in the oligomeric, membrane-perturbing conformation of these essential apoptotic effector molecules. Molecular structures for these dimers have only been captured for truncated constructs encompassing the core domain alone. Here, we report a crystal structure of BAK alpha2-alpha8 dimers (i.e., minus its flexible N-terminal helix and membrane-anchoring C-terminal segment) that has been obtained through the activation of monomeric BAK with the detergent C12E8. Core dimers are evident, linked through the crystal by contacts via latch (alpha6-alpha8) domains. This crystal structure shows activated BAK dimers with the extended latch domain present. Our data provide direct evidence for the conformational change converting BAK from inert monomer to the functional dimer that destroys mitochondrial integrity. This dimer is the smallest functional unit for recombinant BAK or BAX described so far.
		+
		+	Structure of detergent-activated BAK dimers derived from the inert monomer.,Birkinshaw RW, Iyer S, Lio D, Luo CS, Brouwer JM, Miller MS, Robin AY, Uren RT, Dewson G, Kluck RM, Colman PM, Czabotar PE Mol Cell. 2021 Mar 23. pii: S1097-2765(21)00182-9. doi:, 10.1016/j.molcel.2021.03.014. PMID:33794146<ref>PMID:33794146</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7k02" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Birkinshaw RW]]	+	[[Category: Birkinshaw, R W]]
-	[[Category: Czabotar PE]]	+	[[Category: Czabotar, P E]]
		+	[[Category: Apoptosis]]
		+	[[Category: Bak]]
		+	[[Category: Bcl-2 fold]]
		+	[[Category: Bh3-in-groove dimer]]
		+	[[Category: Pore forming]]
		+	[[Category: Proapoptotic]]

OCA at 10:33, 31 March 2021

2021-03-31T10:33:28Z

←Older revision		Revision as of 10:33, 31 March 2021
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-	'''Unreleased structure'''

-	The ~~entry~~ 7k02 ~~is ON HOLD until Paper Publication~~	+	==The crystal structure of a BAK dimer activated by detergent==
-		+	<StructureSection load='7k02' size='340' side='right'caption='[[7k02]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7K02 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7K02 FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7k02 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7k02 OCA], [https://pdbe.org/7k02 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7k02 RCSB], [https://www.ebi.ac.uk/pdbsum/7k02 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7k02 ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Birkinshaw RW]]
		+	[[Category: Czabotar PE]]

OCA at 09:08, 23 September 2020

2020-09-23T09:08:50Z

←Older revision		Revision as of 09:08, 23 September 2020
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7k02 is ON HOLD	+	The entry 7k02 is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7k02" [edit=sysop:move=sysop]

2020-09-09T07:48:30Z

Protected "7k02" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:48, 9 September 2020

OCA: New page: '''Unreleased structure''' The entry 7k02 is ON HOLD Authors: Description: Category: Unreleased Structures

2020-09-09T07:48:27Z

New page: '''Unreleased structure''' The entry 7k02 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7k02 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]