7k6h - Revision history

OCA at 15:18, 18 October 2023

2023-10-18T15:18:40Z

←Older revision		Revision as of 15:18, 18 October 2023
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	<StructureSection load='7k6h' size='340' side='right'caption='[[7k6h]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='7k6h' size='340' side='right'caption='[[7k6h]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[7k6h]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7K6H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7K6H FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7k6h]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7K6H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7K6H FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4WG:2-{[2-ETHOXY-4-(4-HYDROXYPIPERIDIN-1-YL)PHENYL]AMINO}-5,11-DIMETHYL-5,11-DIHYDRO-6H-PYRIMIDO[4,5-B][1,4]BENZODIAZEPIN-6-ONE'>4WG</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.5Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4WG:2-{[2-ETHOXY-4-(4-HYDROXYPIPERIDIN-1-YL)PHENYL]AMINO}-5,11-DIMETHYL-5,11-DIHYDRO-6H-PYRIMIDO[4,5-B][1,4]BENZODIAZEPIN-6-ONE'>4WG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7k6h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7k6h OCA], [https://pdbe.org/7k6h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7k6h RCSB], [https://www.ebi.ac.uk/pdbsum/7k6h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7k6h ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7k6h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7k6h OCA], [https://pdbe.org/7k6h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7k6h RCSB], [https://www.ebi.ac.uk/pdbsum/7k6h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7k6h ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>	+	[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).	+	[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 20:		Line 21:
	</div>		</div>
	<div class="pdbe-citations 7k6h" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 7k6h" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Bromodomain-containing protein 3D structures\|Bromodomain-containing protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Karim~~, M R~~]]	+	[[Category: Karim MR]]
-	[[Category: Schonbrunn, E]]	+	[[Category: Schonbrunn E]]
-	[[Category: Zhu~~, J Y]]~~	+	[[Category: Zhu JY]]
-	~~[[Category: Bet]]~~	+
-	~~[[Category: Dual brd-kinase inhibitor]]~~	+
-	~~[[Category: Erk5]]~~	+
-	~~[[Category: Gene regulation~~]]	+

OCA at 14:12, 17 November 2021

2021-11-17T14:12:48Z

←Older revision		Revision as of 14:12, 17 November 2021
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	==Crystal structure of the first bromodomain (BD1) of human BRD4 bound to XMD8-92==		==Crystal structure of the first bromodomain (BD1) of human BRD4 bound to XMD8-92==
-	<StructureSection load='7k6h' size='340' side='right'caption='[[7k6h]]' scene=''>	+	<StructureSection load='7k6h' size='340' side='right'caption='[[7k6h]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7K6H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7K6H FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7k6h]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7K6H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7K6H FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7k6h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7k6h OCA], [https://pdbe.org/7k6h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7k6h RCSB], [https://www.ebi.ac.uk/pdbsum/7k6h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7k6h ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4WG:2-{[2-ETHOXY-4-(4-HYDROXYPIPERIDIN-1-YL)PHENYL]AMINO}-5,11-DIMETHYL-5,11-DIHYDRO-6H-PYRIMIDO[4,5-B][1,4]BENZODIAZEPIN-6-ONE'>4WG</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7k6h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7k6h OCA], [https://pdbe.org/7k6h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7k6h RCSB], [https://www.ebi.ac.uk/pdbsum/7k6h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7k6h ProSAT]</span></td></tr>
	</table>		</table>
		+	== Disease ==
		+	[[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>
		+	== Function ==
		+	[[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	BRD4 and other members of the bromodomain and extraterminal (BET) family of proteins are promising epigenetic targets for the development of novel therapeutics. Among the reported BRD4 inhibitors are dihydropteridinones and benzopyrimidodiazepinones originally designed to target the kinases PLK1, ERK5, and LRRK2. While these kinase inhibitors were identified as BRD4 inhibitors, little is known about their binding potential and structural details of interaction with the other BET bromodomains. We comprehensively characterized a series of known and newly identified dual BRD4-kinase inhibitors against all eight individual BET bromodomains. A detailed analysis of 23 novel cocrystal structures of BET-kinase inhibitor complexes in combination with direct binding assays and cell signaling studies revealed significant differences in molecular shape complementarity and inhibitory potential. Collectively, the data offer new insights into the action of kinase inhibitors across BET bromodomains, which may aid the development of drugs to inhibit certain BET proteins and kinases differentially.
		+
		+	Differential BET Bromodomain Inhibition by Dihydropteridinone and Pyrimidodiazepinone Kinase Inhibitors.,Karim RM, Bikowitz MJ, Chan A, Zhu JY, Grassie D, Becker A, Berndt N, Gunawan S, Lawrence NJ, Schonbrunn E J Med Chem. 2021 Nov 11;64(21):15772-15786. doi: 10.1021/acs.jmedchem.1c01096., Epub 2021 Oct 28. PMID:34710325<ref>PMID:34710325</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7k6h" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Karim MR]]	+	[[Category: Karim, M R]]
-	[[Category: Schonbrunn E]]	+	[[Category: Schonbrunn, E]]
-	[[Category: Zhu JY]]	+	[[Category: Zhu, J Y]]
		+	[[Category: Bet]]
		+	[[Category: Dual brd-kinase inhibitor]]
		+	[[Category: Erk5]]
		+	[[Category: Gene regulation]]

OCA: Protected "7k6h" [edit=sysop:move=sysop]

2021-09-22T06:50:33Z

Protected "7k6h" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:50, 22 September 2021

OCA: New page: ==Crystal structure of the first bromodomain (BD1) of human BRD4 bound to XMD8-92== == Structural highlig...

2021-09-22T06:50:32Z

New page: ==Crystal structure of the first bromodomain (BD1) of human BRD4 bound to XMD8-92== <StructureSection load='7k6h' size='340' side='right'caption='7k6h' scene=''> == Structural highlig...

New page

==Crystal structure of the first bromodomain (BD1) of human BRD4 bound to XMD8-92==
<StructureSection load='7k6h' size='340' side='right'caption='[[7k6h]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7K6H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7K6H FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7k6h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7k6h OCA], [https://pdbe.org/7k6h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7k6h RCSB], [https://www.ebi.ac.uk/pdbsum/7k6h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7k6h ProSAT]</span></td></tr>
</table>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Karim MR]]
[[Category: Schonbrunn E]]
[[Category: Zhu JY]]