7kgv - Revision history

OCA at 15:24, 18 October 2023

2023-10-18T15:24:45Z

←Older revision		Revision as of 15:24, 18 October 2023
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-	====	+	==Crystal structure of sodium-coupled neutral amino acid transporter SLC38A9 in the N-terminal plugged form==
-	<StructureSection load='7kgv' size='340' side='right'caption='[[7kgv]]' scene=''>	+	<StructureSection load='7kgv' size='340' side='right'caption='[[7kgv]], [[Resolution\|resolution]] 3.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7kgv]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Danio_rerio Danio rerio] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7KGV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7KGV FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7kgv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7kgv OCA], [https://pdbe.org/7kgv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7kgv RCSB], [https://www.ebi.ac.uk/pdbsum/7kgv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7kgv ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.4Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7kgv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7kgv OCA], [https://pdbe.org/7kgv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7kgv RCSB], [https://www.ebi.ac.uk/pdbsum/7kgv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7kgv ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/S38A9_DANRE S38A9_DANRE] Lysosomal amino acid transporter involved in the control of mTORC1 activity in response to amino acids. Probably acts as a amino acid sensor of the Rag GTPases and Ragulator complexes, 2 complexes involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Following activation by amino acids, the Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Mediates transport of amino acids with low capacity, suggesting that it acts as an amino acid sensor instead.[UniProtKB:Q8NBW4]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	mTORC1 is a central hub that integrates environmental cues, such as cellular stresses and nutrient availability to modulate metabolism and cellular responses. Recently, SLC38A9, a lysosomal amino acid transporter, emerged as a sensor for luminal arginine and as an activator of mTORC1. The amino acid-mediated activation of mTORC1 is regulated by the N-terminal domain of SLC38A9. Here, we determined the crystal structure of zebrafish SLC38A9 (drSLC38A9) and found the N-terminal fragment inserted deep within the transporter, bound in the substrate-binding pocket where normally arginine would bind. This represents a significant conformational change of the N-terminal domain (N-plug) when compared with our recent arginine-bound structure of drSLC38A9. We propose a ball-and-chain model for mTORC1 activation, where N-plug insertion and Rag GTPase binding with SLC38A9 is regulated by luminal arginine levels. This work provides important insights into nutrient sensing by SLC38A9 to activate the mTORC1 pathways in response to dietary amino acids.
		+
		+	A conformational change in the N terminus of SLC38A9 signals mTORC1 activation.,Lei HT, Mu X, Hattne J, Gonen T Structure. 2021 May 6;29(5):426-432.e8. doi: 10.1016/j.str.2020.11.014. Epub 2020 , Dec 8. PMID:33296665<ref>PMID:33296665</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7kgv" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Monoclonal Antibodies 3D structures\|Monoclonal Antibodies 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Danio rerio]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Z-disk~~]]	+	[[Category: Mus musculus]]
		+	[[Category: Gonen T]]
		+	[[Category: Hattne J]]
		+	[[Category: Lei H]]
		+	[[Category: Mu X]]

OCA at 10:25, 19 May 2021

2021-05-19T10:25:33Z

←Older revision		Revision as of 10:25, 19 May 2021
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	<StructureSection load='7kgv' size='340' side='right'caption='[[7kgv]]' scene=''>		<StructureSection load='7kgv' size='340' side='right'caption='[[7kgv]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=7kgv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7kgv OCA], [~~http~~://pdbe.org/7kgv PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=7kgv RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/7kgv PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=7kgv ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7kgv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7kgv OCA], [https://pdbe.org/7kgv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7kgv RCSB], [https://www.ebi.ac.uk/pdbsum/7kgv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7kgv ProSAT]</span></td></tr>
	</table>		</table>
	__TOC__		__TOC__

OCA at 10:41, 24 December 2020

2020-12-24T10:41:48Z

←Older revision		Revision as of 10:41, 24 December 2020
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-	'''Unreleased structure'''

-	~~The entry~~ 7kgv ~~is ON HOLD until Paper Publication~~	+	====
-		+	<StructureSection load='7kgv' size='340' side='right'caption='[[7kgv]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=7kgv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7kgv OCA], [http://pdbe.org/7kgv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=7kgv RCSB], [http://www.ebi.ac.uk/pdbsum/7kgv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=7kgv ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Z-disk]]

OCA at 05:35, 4 November 2020

2020-11-04T05:35:39Z

←Older revision		Revision as of 05:35, 4 November 2020
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7kgv is ON HOLD	+	The entry 7kgv is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7kgv" [edit=sysop:move=sysop]

2020-10-28T19:11:09Z

Protected "7kgv" [edit=sysop:move=sysop]

←Older revision

Revision as of 19:11, 28 October 2020

OCA: New page: '''Unreleased structure''' The entry 7kgv is ON HOLD Authors: Description: Category: Unreleased Structures

2020-10-28T19:11:08Z

New page: '''Unreleased structure''' The entry 7kgv is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7kgv is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]