7kjo - Revision history

OCA at 15:26, 18 October 2023

2023-10-18T15:26:19Z

←Older revision		Revision as of 15:26, 18 October 2023
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	<StructureSection load='7kjo' size='340' side='right'caption='[[7kjo]], [[Resolution\|resolution]] 1.45Å' scene=''>		<StructureSection load='7kjo' size='340' side='right'caption='[[7kjo]], [[Resolution\|resolution]] 1.45Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[7kjo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7KJO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7KJO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7kjo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7KJO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7KJO FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>~~, ~~<scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.45Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~PLEKHA7 ([https~~:/~~/www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=~~5&id=9606 HUMAN])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7kjo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7kjo OCA], [https://pdbe.org/7kjo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7kjo RCSB], [https://www.ebi.ac.uk/pdbsum/7kjo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7kjo ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7kjo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7kjo OCA], [https://pdbe.org/7kjo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7kjo RCSB], [https://www.ebi.ac.uk/pdbsum/7kjo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7kjo ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/PKHA7_HUMAN PKHA7_HUMAN]] Required for zonula adherens biogenesis and maintenance (PubMed:19041755). Acts via its interaction with CAMSAP3, which anchors microtubules at their minus-ends to zonula adherens, leading to the recruitment of KIFC3 kinesin to the junctional site (PubMed:19041755). Mediates docking of ADAM10 to zonula adherens through a PDZD11-dependent interaction with the ADAM10-binding protein TSPAN33 (PubMed:30463011).<ref>PMID:19041755</ref> <ref>PMID:30463011</ref>	+	[https://www.uniprot.org/uniprot/PKHA7_HUMAN PKHA7_HUMAN] Required for zonula adherens biogenesis and maintenance (PubMed:19041755). Acts via its interaction with CAMSAP3, which anchors microtubules at their minus-ends to zonula adherens, leading to the recruitment of KIFC3 kinesin to the junctional site (PubMed:19041755). Mediates docking of ADAM10 to zonula adherens through a PDZD11-dependent interaction with the ADAM10-binding protein TSPAN33 (PubMed:30463011).<ref>PMID:19041755</ref> <ref>PMID:30463011</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Aleshin~~, A E~~]]	+	[[Category: Aleshin AE]]
-	[[Category: Liddington~~, R C~~]]	+	[[Category: Liddington RC]]
-	[[Category: Marassi~~, F M]]~~	+	[[Category: Marassi FM]]
-	~~[[Category: Cell adhesion]]~~	+
-	~~[[Category: Inositol-phosphate]]~~	+
-	~~[[Category: Ph domain]]~~	+
-	~~[[Category: Pip]]~~	+
-	~~[[Category: Pleckstrin homology domain]]~~	+
-	~~[[Category: Plekha7~~]]	+

OCA at 09:13, 5 May 2021

2021-05-05T09:13:08Z

←Older revision		Revision as of 09:13, 5 May 2021
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	==crystal structure of PLEKHA7 PH domain biding SO4==		==crystal structure of PLEKHA7 PH domain biding SO4==
-	<StructureSection load='7kjo' size='340' side='right'caption='[[7kjo]]' scene=''>	+	<StructureSection load='7kjo' size='340' side='right'caption='[[7kjo]], [[Resolution\|resolution]] 1.45Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7KJO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7KJO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7kjo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7KJO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7KJO FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7kjo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7kjo OCA], [https://pdbe.org/7kjo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7kjo RCSB], [https://www.ebi.ac.uk/pdbsum/7kjo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7kjo ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PLEKHA7 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7kjo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7kjo OCA], [https://pdbe.org/7kjo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7kjo RCSB], [https://www.ebi.ac.uk/pdbsum/7kjo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7kjo ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[https://www.uniprot.org/uniprot/PKHA7_HUMAN PKHA7_HUMAN]] Required for zonula adherens biogenesis and maintenance (PubMed:19041755). Acts via its interaction with CAMSAP3, which anchors microtubules at their minus-ends to zonula adherens, leading to the recruitment of KIFC3 kinesin to the junctional site (PubMed:19041755). Mediates docking of ADAM10 to zonula adherens through a PDZD11-dependent interaction with the ADAM10-binding protein TSPAN33 (PubMed:30463011).<ref>PMID:19041755</ref> <ref>PMID:30463011</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	PLEKHA7 (pleckstrin homology domain containing family A member 7) plays key roles in intracellular signaling, cytoskeletal organization, and cell adhesion, and is associated with multiple human cancers. The interactions of its pleckstrin homology (PH) domain with membrane phosphatidyl-inositol-phosphate (PIP) lipids are critical for proper cellular localization and function, but little is known about how PLEKHA7 and other PH domains interact with membrane-embedded PIPs. Here we describe the structural basis for recognition of membrane-bound PIPs by PLEHA7. Using X-ray crystallography, nuclear magnetic resonance, molecular dynamics simulations, and isothermal titration calorimetry, we show that the interaction of PLEKHA7 with PIPs is multivalent, distinct from a discrete one-to-one interaction, and induces PIP clustering. Our findings reveal a central role of the membrane assembly in mediating protein-PIP association and provide a roadmap for understanding how the PH domain contributes to the signaling, adhesion, and nanoclustering functions of PLEKHA7.
		+
		+	Structural basis for the association of PLEKHA7 with membrane-embedded phosphatidylinositol lipids.,Aleshin AE, Yao Y, Iftikhar A, Bobkov AA, Yu J, Cadwell G, Klein MG, Dong C, Bankston LA, Liddington RC, Im W, Powis G, Marassi FM Structure. 2021 Apr 13. pii: S0969-2126(21)00116-7. doi:, 10.1016/j.str.2021.03.018. PMID:33878292<ref>PMID:33878292</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7kjo" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Aleshin AE]]	+	[[Category: Aleshin, A E]]
-	[[Category: Liddington RC]]	+	[[Category: Liddington, R C]]
-	[[Category: Marassi FM]]	+	[[Category: Marassi, F M]]
		+	[[Category: Cell adhesion]]
		+	[[Category: Inositol-phosphate]]
		+	[[Category: Ph domain]]
		+	[[Category: Pip]]
		+	[[Category: Pleckstrin homology domain]]
		+	[[Category: Plekha7]]

OCA at 06:52, 7 April 2021

2021-04-07T06:52:25Z

←Older revision		Revision as of 06:52, 7 April 2021
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-	'''Unreleased structure'''

-	~~The entry~~ 7kjo ~~is ON HOLD until Paper Publication~~	+	==crystal structure of PLEKHA7 PH domain biding SO4==
-		+	<StructureSection load='7kjo' size='340' side='right'caption='[[7kjo]]' scene=''>
-	~~Authors~~: ~~Marassi~~, F.M., ~~Aleshin~~, A.E., ~~Liddington~~, R.C.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7KJO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7KJO FirstGlance]. <br>
-	~~Description: crystal structure of PLEKHA7 PH domain biding SO4~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7kjo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7kjo OCA], [https://pdbe.org/7kjo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7kjo RCSB], [https://www.ebi.ac.uk/pdbsum/7kjo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7kjo ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
-	[[Category: ~~Marassi, F.M~~]]	+	__TOC__
-	[[Category: Liddington~~, R.C~~]]	+	</StructureSection>
-	[[Category: ~~Aleshin, A.E~~]]	+	[[Category: Large Structures]]
		+	[[Category: Aleshin AE]]
		+	[[Category: Liddington RC]]
		+	[[Category: Marassi FM]]

OCA at 05:47, 2 December 2020

2020-12-02T05:47:06Z

←Older revision		Revision as of 05:47, 2 December 2020
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7kjo is ON HOLD	+	The entry 7kjo is ON HOLD until Paper Publication

	Authors: Marassi, F.M., Aleshin, A.E., Liddington, R.C.		Authors: Marassi, F.M., Aleshin, A.E., Liddington, R.C.

OCA: Protected "7kjo" [edit=sysop:move=sysop]

2020-11-04T05:39:19Z

Protected "7kjo" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:39, 4 November 2020

OCA: New page: '''Unreleased structure''' The entry 7kjo is ON HOLD Authors: Marassi, F.M., Aleshin, A.E., Liddington, R.C. Description: crystal structure of PLEKHA7 PH domain biding SO4 [[Category: ...

2020-11-04T05:39:18Z

New page: '''Unreleased structure''' The entry 7kjo is ON HOLD Authors: Marassi, F.M., Aleshin, A.E., Liddington, R.C. Description: crystal structure of PLEKHA7 PH domain biding SO4 [[Category: ...

New page

'''Unreleased structure'''

The entry 7kjo is ON HOLD

Authors: Marassi, F.M., Aleshin, A.E., Liddington, R.C.

Description: crystal structure of PLEKHA7 PH domain biding SO4
[[Category: Unreleased Structures]]
[[Category: Marassi, F.M]]
[[Category: Liddington, R.C]]
[[Category: Aleshin, A.E]]