7klp - Revision history

OCA at 09:18, 25 October 2023

2023-10-25T09:18:56Z

←Older revision		Revision as of 09:18, 25 October 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[7klp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7KLP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7KLP FirstGlance]. <br>		<table><tr><td colspan='2'>[[7klp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7KLP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7KLP FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.35Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7klp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7klp OCA], [https://pdbe.org/7klp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7klp RCSB], [https://www.ebi.ac.uk/pdbsum/7klp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7klp ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7klp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7klp OCA], [https://pdbe.org/7klp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7klp RCSB], [https://www.ebi.ac.uk/pdbsum/7klp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7klp ProSAT]</span></td></tr>
	</table>		</table>

OCA at 05:44, 7 June 2023

2023-06-07T05:44:56Z

←Older revision		Revision as of 05:44, 7 June 2023
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	<StructureSection load='7klp' size='340' side='right'caption='[[7klp]], [[Resolution\|resolution]] 1.35Å' scene=''>		<StructureSection load='7klp' size='340' side='right'caption='[[7klp]], [[Resolution\|resolution]] 1.35Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[7klp]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7KLP OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=7KLP FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7klp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7KLP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7KLP FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=7klp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7klp OCA], [~~http~~://pdbe.org/7klp PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=7klp RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/7klp PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=7klp ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7klp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7klp OCA], [https://pdbe.org/7klp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7klp RCSB], [https://www.ebi.ac.uk/pdbsum/7klp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7klp ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Chen~~, E V~~]]	+	[[Category: Chen EV]]
-	[[Category: Li~~, K S~~]]	+	[[Category: Li KS]]
-	[[Category: Yatsunyk~~, L A]]~~	+	[[Category: Yatsunyk LA]]
-	~~[[Category: Dna]]~~	+
-	~~[[Category: G-quadruplex]]~~	+
-	~~[[Category: Human telomeric dna]]~~	+
-	~~[[Category: Parallel]]~~	+
-	~~[[Category: Propeller loop]]~~	+
-	~~[[Category: Three-quartet~~]]	+

OCA at 08:31, 20 January 2021

2021-01-20T08:31:00Z

←Older revision		Revision as of 08:31, 20 January 2021
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	==Crystal structure of a three-tetrad, parallel, K+ stabilized human telomeric G-quadruplex==		==Crystal structure of a three-tetrad, parallel, K+ stabilized human telomeric G-quadruplex==
-	<StructureSection load='7klp' size='340' side='right'caption='[[7klp]]' scene=''>	+	<StructureSection load='7klp' size='340' side='right'caption='[[7klp]], [[Resolution\|resolution]] 1.35Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7KLP OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=7KLP FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7klp]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7KLP OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=7KLP FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=7klp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7klp OCA], [http://pdbe.org/7klp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=7klp RCSB], [http://www.ebi.ac.uk/pdbsum/7klp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=7klp ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=7klp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7klp OCA], [http://pdbe.org/7klp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=7klp RCSB], [http://www.ebi.ac.uk/pdbsum/7klp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=7klp ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Quadruplex DNAs can fold into a variety of distinct topologies, depending in part on loop types and orientations of individual strands, as shown by high-resolution crystal and NMR structures. Crystal structures also show associated water molecules. We report here on an analysis of the hydration arrangements around selected folded quadruplex DNAs, which has revealed several prominent features that re-occur in related structures. Many of the primary-sphere water molecules are found in the grooves and loop regions of these structures. At least one groove in anti-parallel and hybrid quadruplex structures is long and narrow and contains an extensive spine of linked primary-sphere water molecules. This spine is analogous to but fundamentally distinct from the well-characterized spine observed in the minor groove of A/T-rich duplex DNA, in that every water molecule in the continuous quadruplex spines makes a direct hydrogen bond contact with groove atoms, principally phosphate oxygen atoms lining groove walls and guanine base nitrogen atoms on the groove floor. By contrast, parallel quadruplexes do not have extended grooves, but primary-sphere water molecules still cluster in them and are especially associated with the loops, helping to stabilize loop conformations.
		+
		+	Water spines and networks in G-quadruplex structures.,Li K, Yatsunyk L, Neidle S Nucleic Acids Res. 2020 Dec 8. pii: 6027822. doi: 10.1093/nar/gkaa1177. PMID:33290519<ref>PMID:33290519</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7klp" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Chen EV]]	+	[[Category: Chen, E V]]
-	[[Category: Li KS]]	+	[[Category: Li, K S]]
-	[[Category: Yatsunyk LA]]	+	[[Category: Yatsunyk, L A]]
		+	[[Category: Dna]]
		+	[[Category: G-quadruplex]]
		+	[[Category: Human telomeric dna]]
		+	[[Category: Parallel]]
		+	[[Category: Propeller loop]]
		+	[[Category: Three-quartet]]

OCA at 06:49, 30 December 2020

2020-12-30T06:49:41Z

←Older revision		Revision as of 06:49, 30 December 2020
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry 7klp is ON HOLD until Paper Publication~~	+	==Crystal structure of a three-tetrad, parallel, K+ stabilized human telomeric G-quadruplex==
-		+	<StructureSection load='7klp' size='340' side='right'caption='[[7klp]]' scene=''>
-	~~Authors: Yatsunyk, L.A., Li, K.S., Chen, E.V.~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7KLP OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=7KLP FirstGlance]. <br>
-	~~Description:~~ Crystal structure of a three-tetrad, parallel, K+ stabilized human telomeric G-quadruplex	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=7klp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7klp OCA], [http://pdbe.org/7klp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=7klp RCSB], [http://www.ebi.ac.uk/pdbsum/7klp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=7klp ProSAT]</span></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	</table>
-	[[~~Category~~: ~~Yatsunyk~~, L.A]]	+	__TOC__
-	[[Category: Chen~~, E.V~~]]	+	</StructureSection>
-	[[Category: Li~~, K.S~~]]	+	[[Category: Large Structures]]
		+	[[Category: Chen EV]]
		+	[[Category: Li KS]]
		+	[[Category: Yatsunyk LA]]

OCA at 11:10, 16 December 2020

2020-12-16T11:10:25Z

←Older revision		Revision as of 11:10, 16 December 2020
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7klp is ON HOLD	+	The entry 7klp is ON HOLD until Paper Publication

	Authors: Yatsunyk, L.A., Li, K.S., Chen, E.V.		Authors: Yatsunyk, L.A., Li, K.S., Chen, E.V.
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	Description: Crystal structure of a three-tetrad, parallel, K+ stabilized human telomeric G-quadruplex		Description: Crystal structure of a three-tetrad, parallel, K+ stabilized human telomeric G-quadruplex
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Li, K.S]]
-	[[Category: Chen, E.V]]
	[[Category: Yatsunyk, L.A]]		[[Category: Yatsunyk, L.A]]
		+	[[Category: Chen, E.V]]
		+	[[Category: Li, K.S]]

OCA: Protected "7klp" [edit=sysop:move=sysop]

2020-11-11T06:32:57Z

Protected "7klp" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:32, 11 November 2020

OCA: New page: '''Unreleased structure''' The entry 7klp is ON HOLD Authors: Yatsunyk, L.A., Li, K.S., Chen, E.V. Description: Crystal structure of a three-tetrad, parallel, K+ stabilized human telom...

2020-11-11T06:32:56Z

New page: '''Unreleased structure''' The entry 7klp is ON HOLD Authors: Yatsunyk, L.A., Li, K.S., Chen, E.V. Description: Crystal structure of a three-tetrad, parallel, K+ stabilized human telom...

New page

'''Unreleased structure'''

The entry 7klp is ON HOLD

Authors: Yatsunyk, L.A., Li, K.S., Chen, E.V.

Description: Crystal structure of a three-tetrad, parallel, K+ stabilized human telomeric G-quadruplex
[[Category: Unreleased Structures]]
[[Category: Li, K.S]]
[[Category: Chen, E.V]]
[[Category: Yatsunyk, L.A]]