7kpd - Revision history

OCA at 11:13, 14 June 2023

2023-06-14T11:13:59Z

←Older revision		Revision as of 11:13, 14 June 2023
Line 3:		Line 3:
	<StructureSection load='7kpd' size='340' side='right'caption='[[7kpd]]' scene=''>		<StructureSection load='7kpd' size='340' side='right'caption='[[7kpd]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7KPD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7KPD FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7kpd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rinorea_bengalensis Rinorea bengalensis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7KPD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7KPD FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7kpd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7kpd OCA], [https://pdbe.org/7kpd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7kpd RCSB], [https://www.ebi.ac.uk/pdbsum/7kpd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7kpd ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7kpd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7kpd OCA], [https://pdbe.org/7kpd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7kpd RCSB], [https://www.ebi.ac.uk/pdbsum/7kpd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7kpd ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Cyclotides are plant-derived peptides that have attracted interest as biocides and scaffolds for the development of stable peptide therapeutics. Cyclotides are characterized by their cyclic backbone and cystine knot framework, which engenders them with remarkably high stability. This study reports the cystine knot-related peptidome of Rinorea bengalensis, a small rainforest tree in the Violaceae family that is distributed from Australia westward to India. Surprisingly, many more acyclic knotted peptides (acyclotides) were discovered than cyclic counterparts (cyclotides), with 32 acyclotides and 1 cyclotide sequenced using combined transcriptome and proteomic analyses. Nine acyclotides were isolated and screened against a panel of mammalian cell lines, showing they had the cytotoxic properties normally associated with cyclotide-like peptides. NMR analysis of the acyclotide ribes 21 and 22 and the cyclotide ribe 33 confirmed that these peptides contained the cystine knot structural motif. The bracelet-subfamily cyclotide ribe 33 was amenable to chemical synthesis in reasonable yield, an achievement that has long eluded previous attempts to synthetically produce bracelet cyclotides. Accordingly, ribe 33 represents an exciting new bracelet cyclotide scaffold that can be subject to chemical modification for future molecular engineering applications.
		+
		+	In Planta Discovery and Chemical Synthesis of Bracelet Cystine Knot Peptides from Rinorea bengalensis.,Dang TT, Chan LY, Tombling BJ, Harvey PJ, Gilding EK, Craik DJ J Nat Prod. 2021 Feb 11. doi: 10.1021/acs.jnatprod.0c01065. PMID:33570395<ref>PMID:33570395</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7kpd" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
		+	[[Category: Rinorea bengalensis]]
	[[Category: Craik DJ]]		[[Category: Craik DJ]]
	[[Category: Dang TT]]		[[Category: Dang TT]]
	[[Category: Harvey PJ]]		[[Category: Harvey PJ]]

OCA at 06:40, 24 February 2021

2021-02-24T06:40:50Z

←Older revision		Revision as of 06:40, 24 February 2021
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-	'''Unreleased structure'''

-	~~The entry~~ 7kpd ~~is ON HOLD until Paper Publication~~	+	==NMR Solution Structure of Acyclotide ribe 31==
-		+	<StructureSection load='7kpd' size='340' side='right'caption='[[7kpd]]' scene=''>
-	~~Authors~~: ~~Harvey~~, P.J., ~~Craik~~, D.J., ~~Dang~~, T.T.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7KPD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7KPD FirstGlance]. <br>
-	~~Description: NMR Solution Structure of Acyclotide ribe 31~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7kpd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7kpd OCA], [https://pdbe.org/7kpd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7kpd RCSB], [https://www.ebi.ac.uk/pdbsum/7kpd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7kpd ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
-	[[Category: ~~Harvey, P.J~~]]	+	__TOC__
-	[[Category: Dang~~, T.T~~]]	+	</StructureSection>
-	[[Category: ~~Craik, D.J~~]]	+	[[Category: Large Structures]]
		+	[[Category: Craik DJ]]
		+	[[Category: Dang TT]]
		+	[[Category: Harvey PJ]]

OCA at 11:11, 16 December 2020

2020-12-16T11:11:42Z

←Older revision		Revision as of 11:11, 16 December 2020
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7kpd is ON HOLD	+	The entry 7kpd is ON HOLD until Paper Publication

	Authors: Harvey, P.J., Craik, D.J., Dang, T.T.		Authors: Harvey, P.J., Craik, D.J., Dang, T.T.

OCA: Protected "7kpd" [edit=sysop:move=sysop]

2020-11-18T08:11:38Z

Protected "7kpd" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:11, 18 November 2020

OCA: New page: '''Unreleased structure''' The entry 7kpd is ON HOLD Authors: Harvey, P.J., Craik, D.J., Dang, T.T. Description: NMR Solution Structure of Acyclotide ribe 31 [[Category: Unreleased Str...

2020-11-18T08:11:37Z

New page: '''Unreleased structure''' The entry 7kpd is ON HOLD Authors: Harvey, P.J., Craik, D.J., Dang, T.T. Description: NMR Solution Structure of Acyclotide ribe 31 [[Category: Unreleased Str...

New page

'''Unreleased structure'''

The entry 7kpd is ON HOLD

Authors: Harvey, P.J., Craik, D.J., Dang, T.T.

Description: NMR Solution Structure of Acyclotide ribe 31
[[Category: Unreleased Structures]]
[[Category: Harvey, P.J]]
[[Category: Dang, T.T]]
[[Category: Craik, D.J]]