7kx8 - Revision history

OCA at 15:33, 18 October 2023

2023-10-18T15:33:31Z

←Older revision		Revision as of 15:33, 18 October 2023
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	<StructureSection load='7kx8' size='340' side='right'caption='[[7kx8]], [[Resolution\|resolution]] 3.10Å' scene=''>		<StructureSection load='7kx8' size='340' side='right'caption='[[7kx8]], [[Resolution\|resolution]] 3.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[7kx8]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7KX8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7KX8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7kx8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7KX8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7KX8 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=X8J:5-ethyl-2-{[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]amino}-11-methyl-5,11-dihydro-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one'>X8J</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.1Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[7kx6\|7kx6]]</div></td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=X8J:5-ethyl-2-{[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]amino}-11-methyl-5,11-dihydro-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one'>X8J</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7kx8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7kx8 OCA], [https://pdbe.org/7kx8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7kx8 RCSB], [https://www.ebi.ac.uk/pdbsum/7kx8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7kx8 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7kx8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7kx8 OCA], [https://pdbe.org/7kx8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7kx8 RCSB], [https://www.ebi.ac.uk/pdbsum/7kx8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7kx8 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/DCLK1_HUMAN DCLK1_HUMAN]] Probable kinase that may be involved in a calcium-signaling pathway controlling neuronal migration in the developing brain. May also participate in functions of the mature nervous system.	+	[https://www.uniprot.org/uniprot/DCLK1_HUMAN DCLK1_HUMAN] Probable kinase that may be involved in a calcium-signaling pathway controlling neuronal migration in the developing brain. May also participate in functions of the mature nervous system.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 7kx8" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 7kx8" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Serine/threonine protein kinase 3D structures\|Serine/threonine protein kinase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Non-specific serine/threonine protein kinase]]~~	+	[[Category: Lucet I]]
-	[[Category: Lucet, I]]	+	[[Category: Patel O]]
-	[[Category: Patel, O]]	+
-	~~[[Category: Doublecortin-like]]~~	+
-	~~[[Category: Kinase]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 15:51, 27 October 2021

2021-10-27T15:51:12Z

←Older revision		Revision as of 15:51, 27 October 2021
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	==Crystal structure of DCLK1-Cter in complex with FMF-03-055-1==		==Crystal structure of DCLK1-Cter in complex with FMF-03-055-1==
-	<StructureSection load='7kx8' size='340' side='right'caption='[[7kx8]]' scene=''>	+	<StructureSection load='7kx8' size='340' side='right'caption='[[7kx8]], [[Resolution\|resolution]] 3.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7KX8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7KX8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7kx8]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7KX8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7KX8 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7kx8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7kx8 OCA], [https://pdbe.org/7kx8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7kx8 RCSB], [https://www.ebi.ac.uk/pdbsum/7kx8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7kx8 ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=X8J:5-ethyl-2-{[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]amino}-11-methyl-5,11-dihydro-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one'>X8J</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[7kx6\|7kx6]]</div></td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7kx8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7kx8 OCA], [https://pdbe.org/7kx8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7kx8 RCSB], [https://www.ebi.ac.uk/pdbsum/7kx8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7kx8 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[https://www.uniprot.org/uniprot/DCLK1_HUMAN DCLK1_HUMAN]] Probable kinase that may be involved in a calcium-signaling pathway controlling neuronal migration in the developing brain. May also participate in functions of the mature nervous system.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Doublecortin-like kinase 1 (DCLK1) is an understudied bi-functional kinase with a proven role in tumour growth and development. However, the presence of tissue-specific spliced DCLK1 isoforms with distinct biological functions have challenged the development of effective strategies to understand the role of DCLK1 in oncogenesis. Recently, DCLK1-IN-1 was reported as a highly selective DCLK1 inhibitor, a powerful tool to dissect DCLK1 biological functions. Here, we report the crystal structures of DCLK1 kinase domain in complex with DCLK1-IN-1 and its precursors. Combined, our data rationalises the structure-activity relationship that informed the development of DCLK1-IN-1 and provides the basis for the high selectivity of DCLK1-IN-1, with DCLK1-IN-1 inducing a drastic conformational change of the ATP binding site. We demonstrate that DCLK1-IN-1 binds DCLK1 long isoforms but does not prevent DCLK1's Microtubule-Associated Protein (MAP) function. Together, our work provides an invaluable structural platform to further the design of isoform-specific DCLK1 modulators for therapeutic intervention.
		+
		+	Structural basis for small molecule targeting of Doublecortin Like Kinase 1 with DCLK1-IN-1.,Patel O, Roy MJ, Kropp A, Hardy JM, Dai W, Lucet IS Commun Biol. 2021 Sep 20;4(1):1105. doi: 10.1038/s42003-021-02631-y. PMID:34545159<ref>PMID:34545159</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7kx8" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Lucet I]]	+	[[Category: Non-specific serine/threonine protein kinase]]
-	[[Category: Patel O]]	+	[[Category: Lucet, I]]
		+	[[Category: Patel, O]]
		+	[[Category: Doublecortin-like]]
		+	[[Category: Kinase]]
		+	[[Category: Transferase]]

OCA at 06:50, 22 September 2021

2021-09-22T06:50:52Z

←Older revision		Revision as of 06:50, 22 September 2021
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-	'''Unreleased structure'''

-	~~The entry~~ 7kx8 ~~is ON HOLD until Paper Publication~~	+	==Crystal structure of DCLK1-Cter in complex with FMF-03-055-1==
-		+	<StructureSection load='7kx8' size='340' side='right'caption='[[7kx8]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7KX8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7KX8 FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7kx8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7kx8 OCA], [https://pdbe.org/7kx8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7kx8 RCSB], [https://www.ebi.ac.uk/pdbsum/7kx8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7kx8 ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Lucet I]]
		+	[[Category: Patel O]]

OCA at 05:47, 6 January 2021

2021-01-06T05:47:56Z

←Older revision		Revision as of 05:47, 6 January 2021
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7kx8 is ON HOLD	+	The entry 7kx8 is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7kx8" [edit=sysop:move=sysop]

2020-12-09T05:18:38Z

Protected "7kx8" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:18, 9 December 2020

OCA: New page: '''Unreleased structure''' The entry 7kx8 is ON HOLD Authors: Description: Category: Unreleased Structures

2020-12-09T05:18:37Z

New page: '''Unreleased structure''' The entry 7kx8 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7kx8 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]