7ljb - Revision history

OCA at 15:51, 18 October 2023

2023-10-18T15:51:31Z

←Older revision		Revision as of 15:51, 18 October 2023
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-	====	+	==Human TRAAK K+ channel mutant G158D in a K+ bound conductive conformation==
-	<StructureSection load='7ljb' size='340' side='right'caption='[[7ljb]]' scene=''>	+	<StructureSection load='7ljb' size='340' side='right'caption='[[7ljb]], [[Resolution\|resolution]] 2.97Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7ljb]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7LJB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7LJB FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ljb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ljb OCA], [https://pdbe.org/7ljb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ljb RCSB], [https://www.ebi.ac.uk/pdbsum/7ljb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ljb ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.97Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ljb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ljb OCA], [https://pdbe.org/7ljb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ljb RCSB], [https://www.ebi.ac.uk/pdbsum/7ljb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ljb ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/KCNK4_HUMAN KCNK4_HUMAN] Voltage insensitive, instantaneous, outwardly rectifying potassium channel. Outward rectification is reversed at high external K(+) concentrations (By similarity).
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	TRAAK is a mechanosensitive two-pore domain K(+) (K2P) channel localized to nodes of Ranvier in myelinated neurons. TRAAK deletion in mice results in mechanical and thermal allodynia, and gain-of-function mutations cause the human neurodevelopmental disorder FHEIG. TRAAK displays basal and stimulus-gated activities typical of K2Ps, but the mechanistic and structural differences between these modes are unknown. Here, we demonstrate that basal and mechanically gated openings are distinguished by their conductance, kinetics, and structure. Basal openings are low conductance, short duration, and due to a conductive channel conformation with the interior cavity exposed to the surrounding membrane. Mechanically gated openings are high conductance, long duration, and due to a channel conformation in which the interior cavity is sealed to the surrounding membrane. Our results explain how dual modes of activity are produced by a single ion channel and provide a basis for the development of state-selective pharmacology with the potential to treat disease.
		+
		+	Physical basis for distinct basal and mechanically gated activity of the human K(+) channel TRAAK.,Rietmeijer RA, Sorum B, Li B, Brohawn SG Neuron. 2021 Sep 15;109(18):2902-2913.e4. doi: 10.1016/j.neuron.2021.07.009. Epub , 2021 Aug 13. PMID:34390650<ref>PMID:34390650</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7ljb" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Antibody 3D structures\|Antibody 3D structures]]
		+	*[[Potassium channel 3D structures\|Potassium channel 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Z-disk~~]]	+	[[Category: Mus musculus]]
		+	[[Category: Brohawn SG]]
		+	[[Category: Rietmeijer RA]]

OCA at 03:34, 2 July 2021

2021-07-02T03:34:05Z

←Older revision		Revision as of 03:34, 2 July 2021
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-	'''Unreleased structure'''

-	~~The entry~~ 7ljb ~~is ON HOLD until Paper Publication~~	+	====
-		+	<StructureSection load='7ljb' size='340' side='right'caption='[[7ljb]]' scene=''>
-	~~Authors~~: ~~Rietmeijer, R~~.A.~~, Brohawn, S~~.G.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	~~Description: Human TRAAK K+ channel mutant G158D in~~ a ~~K+ bound conductive conformation~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ljb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ljb OCA], [https://pdbe.org/7ljb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ljb RCSB], [https://www.ebi.ac.uk/pdbsum/7ljb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ljb ProSAT]</span></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	</table>
-	[[~~Category~~: ~~Brohawn~~, S.G]]	+	__TOC__
-	[[Category: ~~Rietmeijer, R.A~~]]	+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Z-disk]]

OCA at 09:16, 10 February 2021

2021-02-10T09:16:50Z

←Older revision		Revision as of 09:16, 10 February 2021
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7ljb is ON HOLD	+	The entry 7ljb is ON HOLD until Paper Publication

	Authors: Rietmeijer, R.A., Brohawn, S.G.		Authors: Rietmeijer, R.A., Brohawn, S.G.

-	Description: TRAAK K+ channel mutant G158D in a K+ bound conductive conformation	+	Description: Human TRAAK K+ channel mutant G158D in a K+ bound conductive conformation
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Brohawn, S.G]]		[[Category: Brohawn, S.G]]
	[[Category: Rietmeijer, R.A]]		[[Category: Rietmeijer, R.A]]

OCA: Protected "7ljb" [edit=sysop:move=sysop]

2021-02-03T09:33:12Z

Protected "7ljb" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:33, 3 February 2021

OCA: New page: '''Unreleased structure''' The entry 7ljb is ON HOLD Authors: Rietmeijer, R.A., Brohawn, S.G. Description: TRAAK K+ channel mutant G158D in a K+ bound conductive conformation [[Categor...

2021-02-03T09:33:10Z

New page: '''Unreleased structure''' The entry 7ljb is ON HOLD Authors: Rietmeijer, R.A., Brohawn, S.G. Description: TRAAK K+ channel mutant G158D in a K+ bound conductive conformation [[Categor...

New page

'''Unreleased structure'''

The entry 7ljb is ON HOLD

Authors: Rietmeijer, R.A., Brohawn, S.G.

Description: TRAAK K+ channel mutant G158D in a K+ bound conductive conformation
[[Category: Unreleased Structures]]
[[Category: Brohawn, S.G]]
[[Category: Rietmeijer, R.A]]