OCA at 09:37, 15 September 2021

2021-09-15T09:37:30Z

←Older revision		Revision as of 09:37, 15 September 2021
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	==Structure of the cGAS-like receptor human MB21D2==		==Structure of the cGAS-like receptor human MB21D2==
-	<StructureSection load='7lt1' size='340' side='right'caption='[[7lt1]]' scene=''>	+	<StructureSection load='7lt1' size='340' side='right'caption='[[7lt1]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7LT1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7LT1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7lt1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7LT1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7LT1 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7lt1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7lt1 OCA], [https://pdbe.org/7lt1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7lt1 RCSB], [https://www.ebi.ac.uk/pdbsum/7lt1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7lt1 ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MB21D2, C3orf59 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7lt1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7lt1 OCA], [https://pdbe.org/7lt1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7lt1 RCSB], [https://www.ebi.ac.uk/pdbsum/7lt1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7lt1 ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Cyclic GMP-AMP synthase (cGAS) is a cytosolic DNA sensor that produces the second messenger 2'3'-cGAMP and controls activation of innate immunity in mammalian cells(1-5). Animal genomes typically encode multiple proteins with predicted homology to cGAS(6-10), but the function of these uncharacterized enzymes is unknown. Here we show that cGAS-like receptors (cGLRs) are innate immune sensors capable of recognizing divergent molecular patterns and catalyzing synthesis of distinct nucleotide second messenger signals. Crystal structures of human and insect cGLRs reveal a nucleotidyltransferase signaling core shared with cGAS and a diversified primary ligand-binding surface modified with significant insertions and deletions. We demonstrate that cGLR surface remodeling enables altered ligand specificity and use a forward biochemical screen to identify cGLR1 as a double-stranded RNA sensor in the model organism Drosophila melanogaster. Surprisingly, RNA recognition activates Drosophila cGLR1 to synthesize the novel product cG[3'-5']pA[2'-5']p (3'2'-cGAMP). A crystal structure of Drosophila Stimulator of Interferon Genes (STING) in complex with 3'2'-cGAMP explains selective isomer recognition and we demonstrate that 3'2'-cGAMP induces an enhanced antiviral state in vivo that protects from viral infection. Similar to radiation of Toll-like receptors in pathogen immunity, our results establish cGLRs as a diverse family of metazoan pattern recognition receptors.
		+
		+	cGAS-like receptors sense RNA and control 3'2'-cGAMP signaling in Drosophila.,Slavik KM, Morehouse BR, Ragucci AE, Zhou W, Ai X, Chen Y, Li L, Wei Z, Bahre H, Konig M, Seifert R, Lee ASY, Cai H, Imler JL, Kranzusch PJ Nature. 2021 Jul 14. pii: 10.1038/s41586-021-03743-5. doi:, 10.1038/s41586-021-03743-5. PMID:34261127<ref>PMID:34261127</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7lt1" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Kranzusch PJ]]	+	[[Category: Kranzusch, P J]]
-	[[Category: Morehouse BR]]	+	[[Category: Morehouse, B R]]
-	[[Category: Slavik KM]]	+	[[Category: Slavik, K M]]
		+	[[Category: Cgas-like receptor]]
		+	[[Category: Cglr]]
		+	[[Category: Immune system]]
		+	[[Category: Nucleotidyltransferase]]

OCA at 08:58, 21 July 2021

2021-07-21T08:58:26Z

←Older revision		Revision as of 08:58, 21 July 2021
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-	'''Unreleased structure'''

-	~~The entry~~ 7lt1 is ~~ON HOLD until Paper Publication~~	+	==Structure of the cGAS-like receptor human MB21D2==
-		+	<StructureSection load='7lt1' size='340' side='right'caption='[[7lt1]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7LT1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7LT1 FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7lt1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7lt1 OCA], [https://pdbe.org/7lt1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7lt1 RCSB], [https://www.ebi.ac.uk/pdbsum/7lt1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7lt1 ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Kranzusch PJ]]
		+	[[Category: Morehouse BR]]
		+	[[Category: Slavik KM]]

OCA at 13:24, 3 March 2021

2021-03-03T13:24:05Z

←Older revision		Revision as of 13:24, 3 March 2021
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7lt1 is ON HOLD	+	The entry 7lt1 is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7lt1" [edit=sysop:move=sysop]

2021-02-24T05:44:25Z

Protected "7lt1" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:44, 24 February 2021

OCA: New page: '''Unreleased structure''' The entry 7lt1 is ON HOLD Authors: Description: Category: Unreleased Structures

2021-02-24T05:44:24Z

New page: '''Unreleased structure''' The entry 7lt1 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7lt1 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

7lt1 - Revision history

OCA at 09:37, 15 September 2021

OCA at 08:58, 21 July 2021

OCA at 13:24, 3 March 2021

OCA: Protected "7lt1" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 7lt1 is ON HOLD Authors: Description: Category: Unreleased Structures