7lyf - Revision history

OCA at 16:01, 18 October 2023

2023-10-18T16:01:20Z

←Older revision		Revision as of 16:01, 18 October 2023
Line 3:		Line 3:
	<StructureSection load='7lyf' size='340' side='right'caption='[[7lyf]], [[Resolution\|resolution]] 3.40Å' scene=''>		<StructureSection load='7lyf' size='340' side='right'caption='[[7lyf]], [[Resolution\|resolution]] 3.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[7lyf]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7LYF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7LYF FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7lyf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Dengue_virus_2 Dengue virus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7LYF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7LYF FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.4Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7lyf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7lyf OCA], [https://pdbe.org/7lyf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7lyf RCSB], [https://www.ebi.ac.uk/pdbsum/7lyf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7lyf ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7lyf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7lyf OCA], [https://pdbe.org/7lyf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7lyf RCSB], [https://www.ebi.ac.uk/pdbsum/7lyf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7lyf ProSAT]</span></td></tr>
	</table>		</table>
Line 20:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Dengue virus 2]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Choi~~, K H~~]]	+	[[Category: Choi KH]]
-	[[Category: Lee~~, E H]]~~	+	[[Category: Lee EH]]
-	~~[[Category: Rna~~]]	+

OCA at 10:27, 19 May 2021

2021-05-19T10:27:23Z

←Older revision		Revision as of 10:27, 19 May 2021
Line 1:		Line 1:

	==Dengue virus RNA promoter stem-loop A fused with tRNA-scaffold==		==Dengue virus RNA promoter stem-loop A fused with tRNA-scaffold==
-	<StructureSection load='7lyf' size='340' side='right'caption='[[7lyf]]' scene=''>	+	<StructureSection load='7lyf' size='340' side='right'caption='[[7lyf]], [[Resolution\|resolution]] 3.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7LYF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7LYF FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7lyf]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7LYF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7LYF FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7lyf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7lyf OCA], [https://pdbe.org/7lyf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7lyf RCSB], [https://www.ebi.ac.uk/pdbsum/7lyf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7lyf ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7lyf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7lyf OCA], [https://pdbe.org/7lyf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7lyf RCSB], [https://www.ebi.ac.uk/pdbsum/7lyf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7lyf ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Flaviviruses use a ~70 nucleotide stem-loop structure called stem-loop A (SLA) at the 5' end of the RNA genome as a promoter for RNA synthesis. Flaviviral polymerase NS5 specifically recognizes SLA to initiate RNA synthesis and methylate the 5' guanosine cap. We report the crystal structures of dengue (DENV) and Zika virus (ZIKV) SLAs. DENV and ZIKV SLAs differ in the relative orientations of their top stem-loop helices to bottom stems, but both form an intermolecular three-way junction with a neighboring SLA molecule. To understand how NS5 engages SLA, we determined the SLA-binding site on NS5 and modeled the NS5-SLA complex of DENV and ZIKV. Our results show that the gross conformational differences seen in DENV and ZIKV SLAs can be compensated by the differences in the domain arrangements in DENV and ZIKV NS5s. We describe two binding modes of SLA and NS5 and propose an SLA-mediated RNA synthesis mechanism.
		+
		+	Structures of flavivirus RNA promoters suggest two binding modes with NS5 polymerase.,Lee E, Bujalowski PJ, Teramoto T, Gottipati K, Scott SD, Padmanabhan R, Choi KH Nat Commun. 2021 May 5;12(1):2530. doi: 10.1038/s41467-021-22846-1. PMID:33953197<ref>PMID:33953197</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7lyf" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Choi KH]]	+	[[Category: Choi, K H]]
-	[[Category: Lee EH]]	+	[[Category: Lee, E H]]
		+	[[Category: Rna]]

OCA at 09:22, 12 May 2021

2021-05-12T09:22:02Z

←Older revision		Revision as of 09:22, 12 May 2021
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry 7lyf is ON HOLD until Paper Publication~~	+	==Dengue virus RNA promoter stem-loop A fused with tRNA-scaffold==
-		+	<StructureSection load='7lyf' size='340' side='right'caption='[[7lyf]]' scene=''>
-	~~Authors: Lee, E.H., Choi, K.H.~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7LYF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7LYF FirstGlance]. <br>
-	~~Description:~~ Dengue virus RNA promoter stem-loop A fused with tRNA-scaffold	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7lyf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7lyf OCA], [https://pdbe.org/7lyf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7lyf RCSB], [https://www.ebi.ac.uk/pdbsum/7lyf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7lyf ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
-	[[Category: Choi~~, K.H~~]]	+	__TOC__
-	[[Category: Lee~~, E.H~~]]	+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Choi KH]]
		+	[[Category: Lee EH]]

OCA at 05:31, 24 March 2021

2021-03-24T05:31:01Z

←Older revision		Revision as of 05:31, 24 March 2021
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7lyf is ON HOLD	+	The entry 7lyf is ON HOLD until Paper Publication

	Authors: Lee, E.H., Choi, K.H.		Authors: Lee, E.H., Choi, K.H.

OCA: Protected "7lyf" [edit=sysop:move=sysop]

2021-03-17T05:24:39Z

Protected "7lyf" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:24, 17 March 2021

OCA: New page: '''Unreleased structure''' The entry 7lyf is ON HOLD Authors: Lee, E.H., Choi, K.H. Description: Dengue virus RNA promoter stem-loop A fused with tRNA-scaffold [[Category: Unreleased S...

2021-03-17T05:24:38Z

New page: '''Unreleased structure''' The entry 7lyf is ON HOLD Authors: Lee, E.H., Choi, K.H. Description: Dengue virus RNA promoter stem-loop A fused with tRNA-scaffold [[Category: Unreleased S...

New page

'''Unreleased structure'''

The entry 7lyf is ON HOLD

Authors: Lee, E.H., Choi, K.H.

Description: Dengue virus RNA promoter stem-loop A fused with tRNA-scaffold
[[Category: Unreleased Structures]]
[[Category: Choi, K.H]]
[[Category: Lee, E.H]]