7mds - Revision history

OCA at 16:09, 18 October 2023

2023-10-18T16:09:49Z

←Older revision		Revision as of 16:09, 18 October 2023
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	==Crystal structure of AtDHDPS1 in complex with MBDTA-2==		==Crystal structure of AtDHDPS1 in complex with MBDTA-2==
-	<StructureSection load='7mds' size='340' side='right'caption='[[7mds]]' scene=''>	+	<StructureSection load='7mds' size='340' side='right'caption='[[7mds]], [[Resolution\|resolution]] 2.29Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7MDS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7MDS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7mds]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7MDS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7MDS FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7mds FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7mds OCA], [https://pdbe.org/7mds PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7mds RCSB], [https://www.ebi.ac.uk/pdbsum/7mds PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7mds ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.295Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=YXP:{(5Z)-5-[(4-methoxyphenyl)methylidene]-2,4-dioxo-1,3-thiazolidin-3-yl}acetic+acid'>YXP</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7mds FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7mds OCA], [https://pdbe.org/7mds PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7mds RCSB], [https://www.ebi.ac.uk/pdbsum/7mds PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7mds ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/DAPA1_ARATH DAPA1_ARATH] Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Weeds are becoming increasingly resistant to our current herbicides, posing a significant threat to agricultural production. Therefore, new herbicides with novel modes of action are urgently needed. In this study, we exploited a novel herbicide target, dihydrodipicolinate synthase (DHDPS), which catalyses the first and rate-limiting step in lysine biosynthesis. The first class of plant DHDPS inhibitors with micromolar potency against Arabidopsis thaliana DHDPS were identified using a high throughput chemical screen. We determined that this class of inhibitors binds to a novel and unexplored pocket within DHDPS, which is highly conserved across plant species. The inhibitors also attenuated the germination and growth of A. thaliana seedlings and confirmed their pre-emergence herbicidal activity in soil-grown plants. These results provide proof-of-concept that lysine biosynthesis represents a promising target for the development of herbicides with a novel mode of action to tackle the global rise of herbicide resistant weeds.
		+
		+	Towards novel herbicide modes of action by inhibiting lysine biosynthesis in plants.,Soares da Costa TP, Hall CJ, Panjikar S, Wyllie JA, Christoff RM, Bayat S, Hulett MD, Abbott BM, Gendall AR, Perugini MA Elife. 2021 Jul 27;10. pii: 69444. doi: 10.7554/eLife.69444. PMID:34313586<ref>PMID:34313586</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7mds" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Dihydrodipicolinate synthase\|Dihydrodipicolinate synthase]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Arabidopsis thaliana]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Hall CJ]]		[[Category: Hall CJ]]
	[[Category: Panjikar S]]		[[Category: Panjikar S]]
	[[Category: Soares da Costa TP]]		[[Category: Soares da Costa TP]]

OCA at 10:20, 4 August 2021

2021-08-04T10:20:17Z

←Older revision		Revision as of 10:20, 4 August 2021
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-	'''Unreleased structure'''

-	~~The entry~~ 7mds ~~is ON HOLD until Paper Publication~~	+	==Crystal structure of AtDHDPS1 in complex with MBDTA-2==
-		+	<StructureSection load='7mds' size='340' side='right'caption='[[7mds]]' scene=''>
-	~~Authors~~: ~~Hall~~, C.J., ~~Soares da Costa~~, T.P., ~~Panjikar~~, S.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7MDS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7MDS FirstGlance]. <br>
-	~~Description: Crystal structure of AtDHDPS1 in complex with MBDTA-2~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7mds FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7mds OCA], [https://pdbe.org/7mds PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7mds RCSB], [https://www.ebi.ac.uk/pdbsum/7mds PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7mds ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
-	[[Category: ~~Panjikar, S~~]]	+	__TOC__
-	[[Category: ~~Soares Da Costa, T.P~~]]	+	</StructureSection>
-	[[Category: ~~Hall, C.J~~]]	+	[[Category: Large Structures]]
		+	[[Category: Hall CJ]]
		+	[[Category: Panjikar S]]
		+	[[Category: Soares da Costa TP]]

OCA at 08:08, 12 May 2021

2021-05-12T08:08:43Z

←Older revision		Revision as of 08:08, 12 May 2021
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7mds is ON HOLD	+	The entry 7mds is ON HOLD until Paper Publication

	Authors: Hall, C.J., Soares da Costa, T.P., Panjikar, S.		Authors: Hall, C.J., Soares da Costa, T.P., Panjikar, S.

OCA: Protected "7mds" [edit=sysop:move=sysop]

2021-04-14T05:42:45Z

Protected "7mds" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:42, 14 April 2021

OCA: New page: '''Unreleased structure''' The entry 7mds is ON HOLD Authors: Hall, C.J., Soares da Costa, T.P., Panjikar, S. Description: Crystal structure of AtDHDPS1 in complex with MBDTA-2 [[Categ...

2021-04-14T05:42:44Z

New page: '''Unreleased structure''' The entry 7mds is ON HOLD Authors: Hall, C.J., Soares da Costa, T.P., Panjikar, S. Description: Crystal structure of AtDHDPS1 in complex with MBDTA-2 [[Categ...

New page

'''Unreleased structure'''

The entry 7mds is ON HOLD

Authors: Hall, C.J., Soares da Costa, T.P., Panjikar, S.

Description: Crystal structure of AtDHDPS1 in complex with MBDTA-2
[[Category: Unreleased Structures]]
[[Category: Panjikar, S]]
[[Category: Soares Da Costa, T.P]]
[[Category: Hall, C.J]]