7nnj - Revision history

OCA at 12:37, 1 February 2024

2024-02-01T12:37:24Z

←Older revision		Revision as of 12:37, 1 February 2024
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	==Crystal Structure of NUDT4 (Diphosphoinositol polyphosphate phosphohydrolase 2) in complex with 4-O-Bn-1-PCP-InsP4 (AMR2105)==		==Crystal Structure of NUDT4 (Diphosphoinositol polyphosphate phosphohydrolase 2) in complex with 4-O-Bn-1-PCP-InsP4 (AMR2105)==
-	<StructureSection load='7nnj' size='340' side='right'caption='[[7nnj]]' scene=''>	+	<StructureSection load='7nnj' size='340' side='right'caption='[[7nnj]], [[Resolution\|resolution]] 1.75Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7NNJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7NNJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7nnj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7NNJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7NNJ FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7nnj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7nnj OCA], [https://pdbe.org/7nnj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7nnj RCSB], [https://www.ebi.ac.uk/pdbsum/7nnj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7nnj ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.755Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=UJN:[oxidanyl-[(2S,3R,5S,6S)-4-phenylmethoxy-2,3,5,6-tetraphosphonooxy-cyclohexyl]oxy-phosphoryl]methylphosphonic+acid'>UJN</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7nnj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7nnj OCA], [https://pdbe.org/7nnj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7nnj RCSB], [https://www.ebi.ac.uk/pdbsum/7nnj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7nnj ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/NUDT4_HUMAN NUDT4_HUMAN] Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate), PP-InsP4 and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal transduction. Also able to catalyze the hydrolysis of dinucleoside oligophosphate Ap6A, but not Ap5A. The major reaction products are ADP and p4a from Ap6A. Also able to hydrolyze 5-phosphoribose 1-diphosphate. Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA.<ref>PMID:10777568</ref>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Arruda Bezerra G]]		[[Category: Arruda Bezerra G]]

OCA at 11:17, 23 March 2022

2022-03-23T11:17:32Z

←Older revision		Revision as of 11:17, 23 March 2022
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-	'''Unreleased structure'''

-	~~The entry 7nnj is ON HOLD until Paper Publication~~	+	==Crystal Structure of NUDT4 (Diphosphoinositol polyphosphate phosphohydrolase 2) in complex with 4-O-Bn-1-PCP-InsP4 (AMR2105)==
-		+	<StructureSection load='7nnj' size='340' side='right'caption='[[7nnj]]' scene=''>
-	~~Authors: Dubianok, Y., Arruda Bezerra, G., Raux, B., Diaz Saez, L., Riley, A.M., Potter, B.V.L., Huber, K.V.M., von Delft, F.~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7NNJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7NNJ FirstGlance]. <br>
-	~~Description:~~ Crystal Structure of NUDT4 (Diphosphoinositol polyphosphate phosphohydrolase 2) in complex with 4-O-Bn-1-PCP-InsP4 (AMR2105)	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7nnj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7nnj OCA], [https://pdbe.org/7nnj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7nnj RCSB], [https://www.ebi.ac.uk/pdbsum/7nnj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7nnj ProSAT]</span></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	</table>
-	[[~~Category~~: ~~Raux~~, B]]	+	__TOC__
-	[[Category: ~~Riley, A.M~~]]	+	</StructureSection>
-	[[Category: Diaz Saez, L]]	+	[[Category: Large Structures]]
-	[[Category: Dubianok, Y]]	+	[[Category: Arruda Bezerra G]]
-	[[Category: Huber~~, K.V.M~~]]	+	[[Category: Diaz Saez L]]
-	[[Category: ~~Von Delft, F~~]]	+	[[Category: Dubianok Y]]
-	[[Category: ~~Potter,~~ B~~.V.L~~]]	+	[[Category: Huber KVM]]
-	[[Category: ~~Arruda Bezerra, G~~]]	+	[[Category: Potter BVL]]
		+	[[Category: Raux B]]
		+	[[Category: Riley AM]]
		+	[[Category: Von Delft F]]

OCA at 05:37, 24 March 2021

2021-03-24T05:37:52Z

←Older revision		Revision as of 05:37, 24 March 2021
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7nnj is ON HOLD	+	The entry 7nnj is ON HOLD until Paper Publication

	Authors: Dubianok, Y., Arruda Bezerra, G., Raux, B., Diaz Saez, L., Riley, A.M., Potter, B.V.L., Huber, K.V.M., von Delft, F.		Authors: Dubianok, Y., Arruda Bezerra, G., Raux, B., Diaz Saez, L., Riley, A.M., Potter, B.V.L., Huber, K.V.M., von Delft, F.
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	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Raux, B]]		[[Category: Raux, B]]
-	[[Category: Dubianok, Y]]
-	[[Category: Potter, B.V.L]]
	[[Category: Riley, A.M]]		[[Category: Riley, A.M]]
	[[Category: Diaz Saez, L]]		[[Category: Diaz Saez, L]]
		+	[[Category: Dubianok, Y]]
		+	[[Category: Huber, K.V.M]]
	[[Category: Von Delft, F]]		[[Category: Von Delft, F]]
		+	[[Category: Potter, B.V.L]]
	[[Category: Arruda Bezerra, G]]		[[Category: Arruda Bezerra, G]]
-	[[Category: Huber, K.V.M]]

OCA: Protected "7nnj" [edit=sysop:move=sysop]

2021-03-03T13:37:25Z

Protected "7nnj" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:37, 3 March 2021

OCA: New page: '''Unreleased structure''' The entry 7nnj is ON HOLD Authors: Dubianok, Y., Arruda Bezerra, G., Raux, B., Diaz Saez, L., Riley, A.M., Potter, B.V.L., Huber, K.V.M., von Delft, F. Descr...

2021-03-03T13:37:24Z

New page: '''Unreleased structure''' The entry 7nnj is ON HOLD Authors: Dubianok, Y., Arruda Bezerra, G., Raux, B., Diaz Saez, L., Riley, A.M., Potter, B.V.L., Huber, K.V.M., von Delft, F. Descr...

New page

'''Unreleased structure'''

The entry 7nnj is ON HOLD

Authors: Dubianok, Y., Arruda Bezerra, G., Raux, B., Diaz Saez, L., Riley, A.M., Potter, B.V.L., Huber, K.V.M., von Delft, F.

Description: Crystal Structure of NUDT4 (Diphosphoinositol polyphosphate phosphohydrolase 2) in complex with 4-O-Bn-1-PCP-InsP4 (AMR2105)
[[Category: Unreleased Structures]]
[[Category: Raux, B]]
[[Category: Dubianok, Y]]
[[Category: Potter, B.V.L]]
[[Category: Riley, A.M]]
[[Category: Diaz Saez, L]]
[[Category: Von Delft, F]]
[[Category: Arruda Bezerra, G]]
[[Category: Huber, K.V.M]]