7nrp - Revision history

OCA at 12:38, 1 February 2024

2024-02-01T12:38:51Z

←Older revision		Revision as of 12:38, 1 February 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[7nrp]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7NRP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7NRP FirstGlance]. <br>		<table><tr><td colspan='2'>[[7nrp]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7NRP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7NRP FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CAC:CACODYLATE+ION'>CAC</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.67Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CAC:CACODYLATE+ION'>CAC</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7nrp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7nrp OCA], [https://pdbe.org/7nrp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7nrp RCSB], [https://www.ebi.ac.uk/pdbsum/7nrp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7nrp ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7nrp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7nrp OCA], [https://pdbe.org/7nrp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7nrp RCSB], [https://www.ebi.ac.uk/pdbsum/7nrp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7nrp ProSAT]</span></td></tr>
	</table>		</table>

OCA at 03:49, 8 September 2022

2022-09-08T03:49:29Z

←Older revision		Revision as of 03:49, 8 September 2022
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-	====	+	==The crystal structure of a DNA:RNA hybrid duplex sequence CTTTTCTTTG==
-	<StructureSection load='7nrp' size='340' side='right'caption='[[7nrp]]' scene=''>	+	<StructureSection load='7nrp' size='340' side='right'caption='[[7nrp]], [[Resolution\|resolution]] 2.67Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7nrp]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7NRP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7NRP FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7nrp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7nrp OCA], [https://pdbe.org/7nrp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7nrp RCSB], [https://www.ebi.ac.uk/pdbsum/7nrp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7nrp ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CAC:CACODYLATE+ION'>CAC</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7nrp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7nrp OCA], [https://pdbe.org/7nrp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7nrp RCSB], [https://www.ebi.ac.uk/pdbsum/7nrp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7nrp ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Oligonucleotides that target mRNA have great promise as therapeutic agents for life-threatening conditions but suffer from poor bioavailability, hence high cost. As currently untreatable diseases come within the reach of oligonucleotide therapies, new analogues are urgently needed to address this. With this in mind we describe reduced-charge oligonucleotides containing artificial LNA-amide linkages with improved gymnotic cell uptake, RNA affinity, stability and potency. To construct such oligonucleotides, five LNA-amide monomers (A, T, C, 5mC and G), where the 3'-OH is replaced by an ethanoic acid group, are synthesised in good yield and used in solid-phase oligonucleotide synthesis to form amide linkages with high efficiency. The artificial backbone causes minimal structural deviation to the DNA:RNA duplex. These studies indicate that splice-switching oligonucleotides containing LNA-amide linkages and phosphorothioates display improved activity relative to oligonucleotides lacking amides, highlighting the therapeutic potential of this technology.
		+
		+	An LNA-amide modification that enhances the cell uptake and activity of phosphorothioate exon-skipping oligonucleotides.,Baker YR, Thorpe C, Chen J, Poller LM, Cox L, Kumar P, Lim WF, Lie L, McClorey G, Epple S, Singleton D, McDonough MA, Hardwick JS, Christensen KE, Wood MJA, Hall JP, El-Sagheer AH, Brown T Nat Commun. 2022 Jul 12;13(1):4036. doi: 10.1038/s41467-022-31636-2. PMID:35821218<ref>PMID:35821218</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7nrp" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Z-~~disk~~]]	+	[[Category: Synthetic construct]]
		+	[[Category: Baker YR]]
		+	[[Category: Brown T]]
		+	[[Category: El-Sagheer AH]]
		+	[[Category: Hall JP]]
		+	[[Category: Hardwick J]]
		+	[[Category: McDonough MA]]
		+	[[Category: Thorpe C]]

OCA at 09:44, 22 June 2022

2022-06-22T09:44:00Z

←Older revision		Revision as of 09:44, 22 June 2022
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-	'''Unreleased structure'''

-	~~The entry~~ 7nrp ~~is ON HOLD until Paper Publication~~	+	====
-		+	<StructureSection load='7nrp' size='340' side='right'caption='[[7nrp]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7nrp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7nrp OCA], [https://pdbe.org/7nrp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7nrp RCSB], [https://www.ebi.ac.uk/pdbsum/7nrp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7nrp ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Z-disk]]

OCA at 05:33, 17 March 2021

2021-03-17T05:33:00Z

←Older revision		Revision as of 05:33, 17 March 2021
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7nrp is ON HOLD	+	The entry 7nrp is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7nrp" [edit=sysop:move=sysop]

2021-03-10T15:07:08Z

Protected "7nrp" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:07, 10 March 2021

OCA: New page: '''Unreleased structure''' The entry 7nrp is ON HOLD Authors: Description: Category: Unreleased Structures

2021-03-10T15:07:06Z

New page: '''Unreleased structure''' The entry 7nrp is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7nrp is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]