7nto - Revision history

OCA at 12:39, 1 February 2024

2024-02-01T12:39:35Z

←Older revision		Revision as of 12:39, 1 February 2024
Line 3:		Line 3:
	<StructureSection load='7nto' size='340' side='right'caption='[[7nto]], [[Resolution\|resolution]] 1.23Å' scene=''>		<StructureSection load='7nto' size='340' side='right'caption='[[7nto]], [[Resolution\|resolution]] 1.23Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[7nto]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7NTO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7NTO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7nto]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7NTO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7NTO FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.23Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7nto FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7nto OCA], [https://pdbe.org/7nto PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7nto RCSB], [https://www.ebi.ac.uk/pdbsum/7nto PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7nto ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7nto FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7nto OCA], [https://pdbe.org/7nto PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7nto RCSB], [https://www.ebi.ac.uk/pdbsum/7nto PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7nto ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/TRM2A_HUMAN TRM2A_HUMAN]] May be involved in nucleic acid metabolism and/or modifications.	+	[https://www.uniprot.org/uniprot/TRM2A_HUMAN TRM2A_HUMAN] May be involved in nucleic acid metabolism and/or modifications.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Davydova, E]]	+	[[Category: Davydova E]]
-	[[Category: Janowski, R]]	+	[[Category: Janowski R]]
-	[[Category: Niessing, D]]	+	[[Category: Niessing D]]
-	[[Category: Witzenberger, M]]	+	[[Category: Witzenberger M]]
-	~~[[Category: Methyltransferase]]~~	+
-	~~[[Category: Polyq aggregation]]~~	+
-	~~[[Category: Transferase]]~~	+
-	~~[[Category: Trmt2a]]~~	+
-	~~[[Category: Trna binding~~]]	+

OCA at 07:34, 9 February 2022

2022-02-09T07:34:33Z

←Older revision		Revision as of 07:34, 9 February 2022
Line 1:		Line 1:

	==The structure of RRM domain of human TRMT2A at 1.23 A resolution==		==The structure of RRM domain of human TRMT2A at 1.23 A resolution==
-	<StructureSection load='7nto' size='340' side='right'caption='[[7nto]]' scene=''>	+	<StructureSection load='7nto' size='340' side='right'caption='[[7nto]], [[Resolution\|resolution]] 1.23Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7NTO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7NTO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7nto]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7NTO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7NTO FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7nto FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7nto OCA], [https://pdbe.org/7nto PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7nto RCSB], [https://www.ebi.ac.uk/pdbsum/7nto PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7nto ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7nto FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7nto OCA], [https://pdbe.org/7nto PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7nto RCSB], [https://www.ebi.ac.uk/pdbsum/7nto PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7nto ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[https://www.uniprot.org/uniprot/TRM2A_HUMAN TRM2A_HUMAN]] May be involved in nucleic acid metabolism and/or modifications.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Polyglutamine (polyQ) diseases are characterized by an expansion of cytosine-adenine-guanine (CAG) trinucleotide repeats encoding for an uninterrupted prolonged polyQ tract. We previously identified TRMT2A as a strong modifier of polyQ-induced toxicity in an unbiased large-scale screen in Drosophila melanogaster. This work aimed at identifying and validating pharmacological TRMT2A inhibitors as treatment opportunities for polyQ diseases in humans. Computer-aided drug discovery was implemented to identify human TRMT2A inhibitors. Additionally, the crystal structure of one protein domain, the RNA recognition motif (RRM), was determined, and Biacore experiments with the RRM were performed. The identified molecules were validated for their potency to reduce polyQ aggregation and polyQ-induced cell death in human HEK293T cells and patient derived fibroblasts. Our work provides a first step towards pharmacological inhibition of this enzyme and indicates TRMT2A as a viable drug target for polyQ diseases.
		+
		+	Small-molecule modulators of TRMT2A decrease PolyQ aggregation and PolyQ-induced cell death.,Margreiter MA, Witzenberger M, Wasser Y, Davydova E, Janowski R, Metz J, Habib P, Sahnoun SEM, Sobisch C, Poma B, Palomino-Hernandez O, Wagner M, Carell T, Jon Shah N, Schulz JB, Niessing D, Voigt A, Rossetti G Comput Struct Biotechnol J. 2021 Dec 28;20:443-458. doi:, 10.1016/j.csbj.2021.12.029. eCollection 2022. PMID:35070167<ref>PMID:35070167</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7nto" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Davydova E]]	+	[[Category: Davydova, E]]
-	[[Category: Janowski R]]	+	[[Category: Janowski, R]]
-	[[Category: Niessing D]]	+	[[Category: Niessing, D]]
-	[[Category: Witzenberger M]]	+	[[Category: Witzenberger, M]]
		+	[[Category: Methyltransferase]]
		+	[[Category: Polyq aggregation]]
		+	[[Category: Transferase]]
		+	[[Category: Trmt2a]]
		+	[[Category: Trna binding]]

OCA at 07:29, 19 January 2022

2022-01-19T07:29:31Z

←Older revision		Revision as of 07:29, 19 January 2022
Line 1:		Line 1:
-	'''Unreleased structure'''

-	The ~~entry~~ 7nto ~~is ON HOLD until Paper Publication~~	+	==The structure of RRM domain of human TRMT2A at 1.23 A resolution==
-		+	<StructureSection load='7nto' size='340' side='right'caption='[[7nto]]' scene=''>
-	~~Authors~~: ~~Witzenberger~~, M., ~~Janowski, R~~., ~~Davydova, E~~., ~~Niessing~~, D.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7NTO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7NTO FirstGlance]. <br>
-	~~Description: The structure of RRM domain of human TRMT2A at 1.23 A resolution~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7nto FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7nto OCA], [https://pdbe.org/7nto PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7nto RCSB], [https://www.ebi.ac.uk/pdbsum/7nto PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7nto ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
-	[[Category: Davydova, E]]	+	__TOC__
-	[[Category: ~~Niessing, D~~]]	+	</StructureSection>
-	[[Category: ~~Witzenberger, M~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Janowski, R~~]]	+	[[Category: Davydova E]]
		+	[[Category: Janowski R]]
		+	[[Category: Niessing D]]
		+	[[Category: Witzenberger M]]

OCA at 04:45, 7 April 2021

2021-04-07T04:45:51Z

←Older revision		Revision as of 04:45, 7 April 2021
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7nto is ON HOLD	+	The entry 7nto is ON HOLD until Paper Publication

	Authors: Witzenberger, M., Janowski, R., Davydova, E., Niessing, D.		Authors: Witzenberger, M., Janowski, R., Davydova, E., Niessing, D.

OCA: Protected "7nto" [edit=sysop:move=sysop]

2021-03-17T05:36:39Z

Protected "7nto" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:36, 17 March 2021

OCA: New page: '''Unreleased structure''' The entry 7nto is ON HOLD Authors: Witzenberger, M., Janowski, R., Davydova, E., Niessing, D. Description: The structure of RRM domain of human TRMT2A at 1.2...

2021-03-17T05:36:38Z

New page: '''Unreleased structure''' The entry 7nto is ON HOLD Authors: Witzenberger, M., Janowski, R., Davydova, E., Niessing, D. Description: The structure of RRM domain of human TRMT2A at 1.2...

New page

'''Unreleased structure'''

The entry 7nto is ON HOLD

Authors: Witzenberger, M., Janowski, R., Davydova, E., Niessing, D.

Description: The structure of RRM domain of human TRMT2A at 1.23 A resolution
[[Category: Unreleased Structures]]
[[Category: Davydova, E]]
[[Category: Niessing, D]]
[[Category: Witzenberger, M]]
[[Category: Janowski, R]]