7ntx - Revision history

OCA at 09:32, 26 May 2021

2021-05-26T09:32:49Z

←Older revision		Revision as of 09:32, 26 May 2021
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	==Vip3Bc1 tetramer in processed, activated state==		==Vip3Bc1 tetramer in processed, activated state==
-	<StructureSection load='7ntx' size='340' side='right'caption='[[7ntx]]' scene=''>	+	<StructureSection load='7ntx' size='340' side='right'caption='[[7ntx]], [[Resolution\|resolution]] 4.75Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7NTX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7NTX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7ntx]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_cereus_var._thuringiensis"_smith_et_al._1952 "bacillus cereus var. thuringiensis" smith et al. 1952]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7NTX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7NTX FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ntx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ntx OCA], [https://pdbe.org/7ntx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ntx RCSB], [https://www.ebi.ac.uk/pdbsum/7ntx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ntx ProSAT]</span></td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">vip3Bc1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1428 "Bacillus cereus var. thuringiensis" Smith et al. 1952])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ntx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ntx OCA], [https://pdbe.org/7ntx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ntx RCSB], [https://www.ebi.ac.uk/pdbsum/7ntx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ntx ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Insect pests are a major cause of crop losses worldwide, with an estimated economic cost of $470 billion annually. Biotechnological tools have been introduced to control such insects without the need for chemical pesticides; for instance, the development of transgenic plants harbouring genes encoding insecticidal proteins. The Vip3 (vegetative insecticidal protein 3) family proteins from Bacillus thuringiensis convey toxicity to species within the Lepidoptera, and have wide potential applications in commercial agriculture. Vip3 proteins are proposed to exert their insecticidal activity through pore formation, though to date there is no mechanistic description of how this occurs on the membrane. Here we present cryo-EM structures of a Vip3 family toxin in both inactive and activated forms in conjunction with structural and functional data on toxin-membrane interactions. Together these data demonstrate that activated Vip3Bc1 complex is able to insert into membranes in a highly efficient manner, indicating that receptor binding is the likely driver of Vip3 specificity.
		+
		+	Cryo-EM structures of an insecticidal Bt toxin reveal its mechanism of action on the membrane.,Byrne MJ, Iadanza MG, Perez MA, Maskell DP, George RM, Hesketh EL, Beales PA, Zack MD, Berry C, Thompson RF Nat Commun. 2021 May 14;12(1):2791. doi: 10.1038/s41467-021-23146-4. PMID:33990582<ref>PMID:33990582</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7ntx" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Bacillus cereus var. thuringiensis smith et al. 1952]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Byrne MJ]]	+	[[Category: Byrne, M J]]
-	[[Category: Iadanza MI]]	+	[[Category: Iadanza, M I]]
-	[[Category: Thompson RF]]	+	[[Category: Thompson, R F]]
		+	[[Category: Bt toxin]]
		+	[[Category: Toxin]]
		+	[[Category: Vip3]]

OCA at 06:48, 14 April 2021

2021-04-14T06:48:47Z

←Older revision		Revision as of 06:48, 14 April 2021
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-	'''Unreleased structure'''

-	~~The entry~~ 7ntx ~~is ON HOLD~~	+	==Vip3Bc1 tetramer in processed, activated state==
-		+	<StructureSection load='7ntx' size='340' side='right'caption='[[7ntx]]' scene=''>
-	~~Authors~~: ~~Thompson~~, R.F., ~~Byrne~~, M.J., ~~Iadanza~~, M.I.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7NTX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7NTX FirstGlance]. <br>
-	~~Description: Vip3Bc1 tetramer in processed, activated state~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ntx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ntx OCA], [https://pdbe.org/7ntx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ntx RCSB], [https://www.ebi.ac.uk/pdbsum/7ntx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ntx ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
-	[[Category: ~~Iadanza, M.I~~]]	+	__TOC__
-	[[Category: ~~Byrne, M.J~~]]	+	</StructureSection>
-	[[Category: Thompson~~, R.F~~]]	+	[[Category: Large Structures]]
		+	[[Category: Byrne MJ]]
		+	[[Category: Iadanza MI]]
		+	[[Category: Thompson RF]]

OCA: Protected "7ntx" [edit=sysop:move=sysop]

2021-03-17T05:37:04Z

Protected "7ntx" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:37, 17 March 2021

OCA: New page: '''Unreleased structure''' The entry 7ntx is ON HOLD Authors: Thompson, R.F., Byrne, M.J., Iadanza, M.I. Description: Vip3Bc1 tetramer in processed, activated state [[Category: Unrelea...

2021-03-17T05:37:03Z

New page: '''Unreleased structure''' The entry 7ntx is ON HOLD Authors: Thompson, R.F., Byrne, M.J., Iadanza, M.I. Description: Vip3Bc1 tetramer in processed, activated state [[Category: Unrelea...

New page

'''Unreleased structure'''

The entry 7ntx is ON HOLD

Authors: Thompson, R.F., Byrne, M.J., Iadanza, M.I.

Description: Vip3Bc1 tetramer in processed, activated state
[[Category: Unreleased Structures]]
[[Category: Iadanza, M.I]]
[[Category: Byrne, M.J]]
[[Category: Thompson, R.F]]