7o63 - Revision history

OCA at 12:45, 1 February 2024

2024-02-01T12:45:23Z

←Older revision		Revision as of 12:45, 1 February 2024
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	<StructureSection load='7o63' size='340' side='right'caption='[[7o63]], [[Resolution\|resolution]] 1.16Å' scene=''>		<StructureSection load='7o63' size='340' side='right'caption='[[7o63]], [[Resolution\|resolution]] 1.16Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[7o63]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7O63 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7O63 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7o63]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7O63 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7O63 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>~~, ~~<scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.16Å</td></tr>
-	<tr id='~~activity~~'><td class="sblockLbl"><b>~~Activity~~:</b></td><td class="sblockDat"><~~span class~~='~~plainlinks~~'>~~[https:~~/~~/en.wikipedia.org/wiki/Ferroxidase Ferroxidase]~~, ~~with EC number [https~~:~~//www.brenda-enzymes.info/php/result_flat.php4?ecno=1.16.3.1 1.16.3.1]~~ </~~span~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7o63 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7o63 OCA], [https://pdbe.org/7o63 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7o63 RCSB], [https://www.ebi.ac.uk/pdbsum/7o63 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7o63 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7o63 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7o63 OCA], [https://pdbe.org/7o63 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7o63 RCSB], [https://www.ebi.ac.uk/pdbsum/7o63 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7o63 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/FTMT_HUMAN FTMT_HUMAN]] Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.<ref>PMID:11323407</ref> <ref>PMID:15201052</ref>	+	[https://www.uniprot.org/uniprot/FTMT_HUMAN FTMT_HUMAN] Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.<ref>PMID:11323407</ref> <ref>PMID:15201052</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 7o63" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 7o63" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Ferritin 3D structures\|Ferritin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Ferroxidase~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Ciambellotti, S]]	+	[[Category: Ciambellotti S]]
-	[[Category: Mangani, S]]	+	[[Category: Mangani S]]
-	[[Category: Pozzi, C]]	+	[[Category: Pozzi C]]
-	[[Category: Tassone, G]]	+	[[Category: Tassone G]]
-	[[Category: Turano, P]]	+	[[Category: Turano P]]
-	~~[[Category: High resolution]]~~	+
-	~~[[Category: Hmtf]]~~	+
-	~~[[Category: Human mitochondrial ferritin]]~~	+
-	~~[[Category: Oxidoreductase~~]]	+

OCA at 16:00, 3 November 2021

2021-11-03T16:00:57Z

←Older revision		Revision as of 16:00, 3 November 2021
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	==High resolution crystal structure of human mitochondrial ferritin (hMTF)==		==High resolution crystal structure of human mitochondrial ferritin (hMTF)==
-	<StructureSection load='7o63' size='340' side='right'caption='[[7o63]]' scene=''>	+	<StructureSection load='7o63' size='340' side='right'caption='[[7o63]], [[Resolution\|resolution]] 1.16Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7O63 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7O63 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7o63]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7O63 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7O63 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7o63 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7o63 OCA], [https://pdbe.org/7o63 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7o63 RCSB], [https://www.ebi.ac.uk/pdbsum/7o63 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7o63 ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Ferroxidase Ferroxidase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.16.3.1 1.16.3.1] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7o63 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7o63 OCA], [https://pdbe.org/7o63 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7o63 RCSB], [https://www.ebi.ac.uk/pdbsum/7o63 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7o63 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[https://www.uniprot.org/uniprot/FTMT_HUMAN FTMT_HUMAN]] Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.<ref>PMID:11323407</ref> <ref>PMID:15201052</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Ferritins are nanocage proteins that store iron ions in their central cavity as hydrated ferric oxide biominerals. In mammals, further the L (light) and H (heavy) chains constituting cytoplasmic maxi-ferritins, an additional type of ferritin has been identified, the mitochondrial ferritin (MTF). Human MTF (hMTF) is a functional homopolymeric H-like ferritin performing the ferroxidase activity in its ferroxidase site (FS), in which Fe(II) is oxidized to Fe(III) in the presence of dioxygen. To better investigate its ferroxidase properties, here we performed time-lapse X-ray crystallography analysis of hMTF, providing structural evidence of how iron ions interact with hMTF and of their binding to the FS. Transient iron binding sites, populating the pathway along the cage from the iron entry channel to the catalytic center, were also identified. Furthermore, our kinetic data at variable iron loads indicate that the catalytic iron oxidation reaction occurs via a diferric peroxo intermediate followed by the formation of ferric-oxo species, with significant differences with respect to human H-type ferritin.
		+
		+	Iron Binding in the Ferroxidase Site of Human Mitochondrial Ferritin.,Ciambellotti S, Pratesi A, Tassone G, Turano P, Mangani S, Pozzi C Chemistry. 2021 Aug 3. doi: 10.1002/chem.202102270. PMID:34343376<ref>PMID:34343376</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7o63" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Ferroxidase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Ciambellotti S]]	+	[[Category: Ciambellotti, S]]
-	[[Category: Mangani S]]	+	[[Category: Mangani, S]]
-	[[Category: Pozzi C]]	+	[[Category: Pozzi, C]]
-	[[Category: Tassone G]]	+	[[Category: Tassone, G]]
-	[[Category: Turano P]]	+	[[Category: Turano, P]]
		+	[[Category: High resolution]]
		+	[[Category: Hmtf]]
		+	[[Category: Human mitochondrial ferritin]]
		+	[[Category: Oxidoreductase]]

OCA at 11:43, 13 October 2021

2021-10-13T11:43:52Z

←Older revision		Revision as of 11:43, 13 October 2021
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 7o63 ~~is ON HOLD until Paper Publication~~	+	==High resolution crystal structure of human mitochondrial ferritin (hMTF)==
-		+	<StructureSection load='7o63' size='340' side='right'caption='[[7o63]]' scene=''>
-	~~Authors~~: ~~Pozzi~~, C., ~~Ciambellotti, S~~., ~~Tassone, G~~., ~~Turano, P~~., ~~Mangani, S~~.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7O63 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7O63 FirstGlance]. <br>
-	~~Description: High resolution crystal structure of human mitochondrial ferritin (hMTF)~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7o63 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7o63 OCA], [https://pdbe.org/7o63 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7o63 RCSB], [https://www.ebi.ac.uk/pdbsum/7o63 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7o63 ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
-	[[Category: ~~Mangani,~~ S]]	+	__TOC__
-	[[Category: ~~Ciambellotti,~~ S]]	+	</StructureSection>
-	[[Category: ~~Turano, P~~]]	+	[[Category: Large Structures]]
-	[[Category: Tassone, G]]	+	[[Category: Ciambellotti S]]
-	[[Category: ~~Pozzi, C~~]]	+	[[Category: Mangani S]]
		+	[[Category: Pozzi C]]
		+	[[Category: Tassone G]]
		+	[[Category: Turano P]]

OCA at 08:19, 12 May 2021

2021-05-12T08:19:31Z

←Older revision		Revision as of 08:19, 12 May 2021
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7o63 is ON HOLD	+	The entry 7o63 is ON HOLD until Paper Publication

	Authors: Pozzi, C., Ciambellotti, S., Tassone, G., Turano, P., Mangani, S.		Authors: Pozzi, C., Ciambellotti, S., Tassone, G., Turano, P., Mangani, S.

OCA: Protected "7o63" [edit=sysop:move=sysop]

2021-04-21T06:36:56Z

Protected "7o63" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:36, 21 April 2021

OCA: New page: '''Unreleased structure''' The entry 7o63 is ON HOLD Authors: Pozzi, C., Ciambellotti, S., Tassone, G., Turano, P., Mangani, S. Description: High resolution crystal structure of human ...

2021-04-21T06:36:54Z

New page: '''Unreleased structure''' The entry 7o63 is ON HOLD Authors: Pozzi, C., Ciambellotti, S., Tassone, G., Turano, P., Mangani, S. Description: High resolution crystal structure of human ...

New page

'''Unreleased structure'''

The entry 7o63 is ON HOLD

Authors: Pozzi, C., Ciambellotti, S., Tassone, G., Turano, P., Mangani, S.

Description: High resolution crystal structure of human mitochondrial ferritin (hMTF)
[[Category: Unreleased Structures]]
[[Category: Mangani, S]]
[[Category: Ciambellotti, S]]
[[Category: Turano, P]]
[[Category: Tassone, G]]
[[Category: Pozzi, C]]