7o9h - Revision history

OCA at 12:47, 1 February 2024

2024-02-01T12:47:46Z

←Older revision		Revision as of 12:47, 1 February 2024
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	==See Also==		==See Also==
-	*[[Signal recognition particle receptor\|Signal recognition particle receptor]]	+	*[[Signal recognition particle receptor 3D structures\|Signal recognition particle receptor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 10:05, 27 September 2023

2023-09-27T10:05:29Z

←Older revision		Revision as of 10:05, 27 September 2023
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	<StructureSection load='7o9h' size='340' side='right'caption='[[7o9h]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='7o9h' size='340' side='right'caption='[[7o9h]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[7o9h]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7O9H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7O9H FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7o9h]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_DH5alpha Escherichia coli DH5alpha]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7O9H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7O9H FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C1Z:guanosine+3-diphosphate+5-triphosphate'>C1Z</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.4Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C1Z:guanosine+3-diphosphate+5-triphosphate'>C1Z</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7o9h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7o9h OCA], [https://pdbe.org/7o9h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7o9h RCSB], [https://www.ebi.ac.uk/pdbsum/7o9h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7o9h ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7o9h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7o9h OCA], [https://pdbe.org/7o9h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7o9h RCSB], [https://www.ebi.ac.uk/pdbsum/7o9h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7o9h ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/FTSY_ECOLI FTSY_ECOLI] Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components.<ref>PMID:8194520</ref> <ref>PMID:9305630</ref> <ref>PMID:11735405</ref> <ref>PMID:11741850</ref> <ref>PMID:15148364</ref> <ref>PMID:17682051</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 7o9h" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 7o9h" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Signal recognition particle receptor\|Signal recognition particle receptor]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Bange, G]]	+	[[Category: Bange G]]
-	[[Category: Czech, L]]	+	[[Category: Czech L]]
-	[[Category: Mais, C N]]	+	[[Category: Mais C-N]]
-	~~[[Category: Alarmone]]~~	+
-	~~[[Category: Signal recognition particle]]~~	+
-	~~[[Category: Stress]]~~	+
-	~~[[Category: Stringent response]]~~	+
-	~~[[Category: Targeting complex]]~~	+
-	~~[[Category: Translation~~]]	+

OCA at 07:23, 9 March 2022

2022-03-09T07:23:58Z

←Older revision		Revision as of 07:23, 9 March 2022
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	==Escherichia coli FtsY in complex with pppGpp==		==Escherichia coli FtsY in complex with pppGpp==
-	<StructureSection load='7o9h' size='340' side='right'caption='[[7o9h]]' scene=''>	+	<StructureSection load='7o9h' size='340' side='right'caption='[[7o9h]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7O9H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7O9H FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7o9h]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7O9H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7O9H FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7o9h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7o9h OCA], [https://pdbe.org/7o9h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7o9h RCSB], [https://www.ebi.ac.uk/pdbsum/7o9h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7o9h ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C1Z:guanosine+3-diphosphate+5-triphosphate'>C1Z</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7o9h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7o9h OCA], [https://pdbe.org/7o9h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7o9h RCSB], [https://www.ebi.ac.uk/pdbsum/7o9h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7o9h ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The stringent response enables bacteria to respond to nutrient limitation and other stress conditions through production of the nucleotide-based second messengers ppGpp and pppGpp, collectively known as (p)ppGpp. Here, we report that (p)ppGpp inhibits the signal recognition particle (SRP)-dependent protein targeting pathway, which is essential for membrane protein biogenesis and protein secretion. More specifically, (p)ppGpp binds to the SRP GTPases Ffh and FtsY, and inhibits the formation of the SRP receptor-targeting complex, which is central for the coordinated binding of the translating ribosome to the SecYEG translocon. Cryo-EM analysis of SRP bound to translating ribosomes suggests that (p)ppGpp may induce a distinct conformational stabilization of the NG domain of Ffh and FtsY in Bacillus subtilis but not in E. coli.
		+
		+	Inhibition of SRP-dependent protein secretion by the bacterial alarmone (p)ppGpp.,Czech L, Mais CN, Kratzat H, Sarmah P, Giammarinaro P, Freibert SA, Esser HF, Musial J, Berninghausen O, Steinchen W, Beckmann R, Koch HG, Bange G Nat Commun. 2022 Feb 25;13(1):1069. doi: 10.1038/s41467-022-28675-0. PMID:35217658<ref>PMID:35217658</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7o9h" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Bange G]]	+	[[Category: Bange, G]]
-	[[Category: Czech L]]	+	[[Category: Czech, L]]
-	[[Category: Mais C-N]]	+	[[Category: Mais, C N]]
		+	[[Category: Alarmone]]
		+	[[Category: Signal recognition particle]]
		+	[[Category: Stress]]
		+	[[Category: Stringent response]]
		+	[[Category: Targeting complex]]
		+	[[Category: Translation]]

OCA at 07:00, 2 February 2022

2022-02-02T07:00:54Z

←Older revision		Revision as of 07:00, 2 February 2022
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-	'''Unreleased structure'''

-	~~The entry~~ 7o9h ~~is ON HOLD until Paper Publication~~	+	==Escherichia coli FtsY in complex with pppGpp==
-		+	<StructureSection load='7o9h' size='340' side='right'caption='[[7o9h]]' scene=''>
-	~~Authors~~: ~~Czech~~, L., ~~Mais~~, C.-N., ~~Bange~~, G.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7O9H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7O9H FirstGlance]. <br>
-	~~Description: Escherichia coli FtsY in complex with pppGpp~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7o9h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7o9h OCA], [https://pdbe.org/7o9h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7o9h RCSB], [https://www.ebi.ac.uk/pdbsum/7o9h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7o9h ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
-	[[Category: Bange, G]]	+	__TOC__
-	[[Category: Czech, L]]	+	</StructureSection>
-	[[Category: Mais, C.-N]]	+	[[Category: Large Structures]]
		+	[[Category: Bange G]]
		+	[[Category: Czech L]]
		+	[[Category: Mais C-N]]

OCA at 09:02, 19 May 2021

2021-05-19T09:02:37Z

←Older revision		Revision as of 09:02, 19 May 2021
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7o9h is ON HOLD	+	The entry 7o9h is ON HOLD until Paper Publication

	Authors: Czech, L., Mais, C.-N., Bange, G.		Authors: Czech, L., Mais, C.-N., Bange, G.

OCA: Protected "7o9h" [edit=sysop:move=sysop]

2021-04-21T06:47:26Z

Protected "7o9h" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:47, 21 April 2021

OCA: New page: '''Unreleased structure''' The entry 7o9h is ON HOLD Authors: Czech, L., Mais, C.-N., Bange, G. Description: Escherichia coli FtsY in complex with pppGpp [[Category: Unreleased Structu...

2021-04-21T06:47:24Z

New page: '''Unreleased structure''' The entry 7o9h is ON HOLD Authors: Czech, L., Mais, C.-N., Bange, G. Description: Escherichia coli FtsY in complex with pppGpp [[Category: Unreleased Structu...

New page

'''Unreleased structure'''

The entry 7o9h is ON HOLD

Authors: Czech, L., Mais, C.-N., Bange, G.

Description: Escherichia coli FtsY in complex with pppGpp
[[Category: Unreleased Structures]]
[[Category: Bange, G]]
[[Category: Czech, L]]
[[Category: Mais, C.-N]]