7opg - Revision history

OCA at 12:54, 1 February 2024

2024-02-01T12:54:10Z

←Older revision		Revision as of 12:54, 1 February 2024
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	==Crystal structure of CLK1 in complex with compound 2 (CC513)==		==Crystal structure of CLK1 in complex with compound 2 (CC513)==
-	<StructureSection load='7opg' size='340' side='right'caption='[[7opg]]' scene=''>	+	<StructureSection load='7opg' size='340' side='right'caption='[[7opg]], [[Resolution\|resolution]] 1.93Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7OPG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7OPG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7opg]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7OPG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7OPG FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7opg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7opg OCA], [https://pdbe.org/7opg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7opg RCSB], [https://www.ebi.ac.uk/pdbsum/7opg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7opg ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.93Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=06N:4-[2-(propylamino)imidazo[2,1-b][1,3,4]thiadiazol-5-yl]phenol'>06N</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7opg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7opg OCA], [https://pdbe.org/7opg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7opg RCSB], [https://www.ebi.ac.uk/pdbsum/7opg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7opg ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/CLK1_HUMAN CLK1_HUMAN] Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates: SRSF1, SRSF3 and PTPN1. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells and adenovirus E1A pre-mRNA.<ref>PMID:10480872</ref> <ref>PMID:19168442</ref>
		+
		+	==See Also==
		+	*[[Dual specificity protein kinase 3D structures\|Dual specificity protein kinase 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Bonnet P]]		[[Category: Bonnet P]]

OCA at 08:59, 21 July 2021

2021-07-21T08:59:57Z

←Older revision		Revision as of 08:59, 21 July 2021
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-	'''Unreleased structure'''

-	~~The entry 7opg is ON HOLD~~	+	==Crystal structure of CLK1 in complex with compound 2 (CC513)==
-		+	<StructureSection load='7opg' size='340' side='right'caption='[[7opg]]' scene=''>
-	~~Authors: Chaikuad, A., Routier, S., Bonnet, P., Knapp, S., Structural Genomics Consortium (SGC)~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7OPG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7OPG FirstGlance]. <br>
-	~~Description:~~ Crystal structure of CLK1 in complex with compound 2 (CC513)	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7opg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7opg OCA], [https://pdbe.org/7opg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7opg RCSB], [https://www.ebi.ac.uk/pdbsum/7opg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7opg ProSAT]</span></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	</table>
-	[[~~Category~~: ~~Chaikuad~~, A]]	+	__TOC__
-	[[Category: ~~Knapp, S~~]]	+	</StructureSection>
-	[[Category: ~~Routier, S~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Bonnet, P~~]]	+	[[Category: Bonnet P]]
-	[[Category: ~~Structural Genomics Consortium (Sgc)~~]]	+	[[Category: Chaikuad A]]
		+	[[Category: Knapp S]]
		+	[[Category: Routier S]]

OCA: Protected "7opg" [edit=sysop:move=sysop]

2021-06-09T11:14:35Z

Protected "7opg" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:14, 9 June 2021

OCA: New page: '''Unreleased structure''' The entry 7opg is ON HOLD Authors: Chaikuad, A., Routier, S., Bonnet, P., Knapp, S., Structural Genomics Consortium (SGC) Description: Crystal structure of C...

2021-06-09T11:14:34Z

New page: '''Unreleased structure''' The entry 7opg is ON HOLD Authors: Chaikuad, A., Routier, S., Bonnet, P., Knapp, S., Structural Genomics Consortium (SGC) Description: Crystal structure of C...

New page

'''Unreleased structure'''

The entry 7opg is ON HOLD

Authors: Chaikuad, A., Routier, S., Bonnet, P., Knapp, S., Structural Genomics Consortium (SGC)

Description: Crystal structure of CLK1 in complex with compound 2 (CC513)
[[Category: Unreleased Structures]]
[[Category: Chaikuad, A]]
[[Category: Knapp, S]]
[[Category: Routier, S]]
[[Category: Bonnet, P]]
[[Category: Structural Genomics Consortium (Sgc)]]