7ow2 - Revision history

OCA at 12:57, 1 February 2024

2024-02-01T12:57:13Z

←Older revision		Revision as of 12:57, 1 February 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[7ow2]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7OW2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7OW2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[7ow2]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7OW2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7OW2 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.17Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ow2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ow2 OCA], [https://pdbe.org/7ow2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ow2 RCSB], [https://www.ebi.ac.uk/pdbsum/7ow2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ow2 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ow2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ow2 OCA], [https://pdbe.org/7ow2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ow2 RCSB], [https://www.ebi.ac.uk/pdbsum/7ow2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ow2 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/TRIM7_HUMAN TRIM7_HUMAN]] E3 ubiquitin-protein ligase. Mediates 'Lys-63'-linked polyubiquitination and stabilization of the JUN coactivator RNF187 in response to growth factor signaling via the MEK/ERK pathway, thereby regulating JUN transactivation and cellular proliferation (PubMed:25851810). Promotes the TLR4-mediated signaling activation through its E3 ligase domain leading to production of proinflammatory cytokines and type I interferon (By similarity). Plays also a negative role in the regulation of exogenous cytosolic DNA virus-triggered immune response. Mechanistically, enhances the 'Lys-48'-linked ubiquitination of STING1 leading to its proteasome-dependent degradation (PubMed:32126128).[UniProtKB:Q923T7]<ref>PMID:25851810</ref> <ref>PMID:32126128</ref> (Microbial infection) Promotes Zika virus replication by mediating envelope protein E ubiquitination.<ref>PMID:32641828</ref>	+	[https://www.uniprot.org/uniprot/TRIM7_HUMAN TRIM7_HUMAN] E3 ubiquitin-protein ligase. Mediates 'Lys-63'-linked polyubiquitination and stabilization of the JUN coactivator RNF187 in response to growth factor signaling via the MEK/ERK pathway, thereby regulating JUN transactivation and cellular proliferation (PubMed:25851810). Promotes the TLR4-mediated signaling activation through its E3 ligase domain leading to production of proinflammatory cytokines and type I interferon (By similarity). Plays also a negative role in the regulation of exogenous cytosolic DNA virus-triggered immune response. Mechanistically, enhances the 'Lys-48'-linked ubiquitination of STING1 leading to its proteasome-dependent degradation (PubMed:32126128).[UniProtKB:Q923T7]<ref>PMID:25851810</ref> <ref>PMID:32126128</ref> (Microbial infection) Promotes Zika virus replication by mediating envelope protein E ubiquitination.<ref>PMID:32641828</ref>
	== References ==		== References ==
	<references/>		<references/>

OCA at 05:41, 8 September 2022

2022-09-08T05:41:25Z

←Older revision		Revision as of 05:41, 8 September 2022
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-	====	+	==E3 RING ligase binding domain with peptide==
-	<StructureSection load='7ow2' size='340' side='right'caption='[[7ow2]]' scene=''>	+	<StructureSection load='7ow2' size='340' side='right'caption='[[7ow2]], [[Resolution\|resolution]] 2.17Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7ow2]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7OW2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7OW2 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ow2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ow2 OCA], [https://pdbe.org/7ow2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ow2 RCSB], [https://www.ebi.ac.uk/pdbsum/7ow2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ow2 ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ow2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ow2 OCA], [https://pdbe.org/7ow2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ow2 RCSB], [https://www.ebi.ac.uk/pdbsum/7ow2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ow2 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[https://www.uniprot.org/uniprot/TRIM7_HUMAN TRIM7_HUMAN]] E3 ubiquitin-protein ligase. Mediates 'Lys-63'-linked polyubiquitination and stabilization of the JUN coactivator RNF187 in response to growth factor signaling via the MEK/ERK pathway, thereby regulating JUN transactivation and cellular proliferation (PubMed:25851810). Promotes the TLR4-mediated signaling activation through its E3 ligase domain leading to production of proinflammatory cytokines and type I interferon (By similarity). Plays also a negative role in the regulation of exogenous cytosolic DNA virus-triggered immune response. Mechanistically, enhances the 'Lys-48'-linked ubiquitination of STING1 leading to its proteasome-dependent degradation (PubMed:32126128).[UniProtKB:Q923T7]<ref>PMID:25851810</ref> <ref>PMID:32126128</ref> (Microbial infection) Promotes Zika virus replication by mediating envelope protein E ubiquitination.<ref>PMID:32641828</ref>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Z-disk~~]]	+	[[Category: James LC]]

OCA at 05:13, 13 July 2022

2022-07-13T05:13:44Z

←Older revision		Revision as of 05:13, 13 July 2022
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-	'''Unreleased structure'''

-	~~The entry~~ 7ow2 ~~is ON HOLD until Paper Publication~~	+	====
-		+	<StructureSection load='7ow2' size='340' side='right'caption='[[7ow2]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ow2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ow2 OCA], [https://pdbe.org/7ow2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ow2 RCSB], [https://www.ebi.ac.uk/pdbsum/7ow2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ow2 ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Z-disk]]

OCA at 07:52, 21 July 2021

2021-07-21T07:52:51Z

←Older revision		Revision as of 07:52, 21 July 2021
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7ow2 is ON HOLD	+	The entry 7ow2 is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7ow2" [edit=sysop:move=sysop]

2021-06-25T06:25:28Z

Protected "7ow2" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:25, 25 June 2021

OCA: New page: '''Unreleased structure''' The entry 7ow2 is ON HOLD Authors: Description: Category: Unreleased Structures

2021-06-25T06:25:26Z

New page: '''Unreleased structure''' The entry 7ow2 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7ow2 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]