7p0z - Revision history

OCA at 12:58, 13 October 2021

2021-10-13T12:58:34Z

←Older revision		Revision as of 12:58, 13 October 2021
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	==2.43 A Mycobacterium marinum EspB.==		==2.43 A Mycobacterium marinum EspB.==
-	<StructureSection load='7p0z' size='340' side='right'caption='[[7p0z]]' scene=''>	+	<StructureSection load='7p0z' size='340' side='right'caption='[[7p0z]], [[Resolution\|resolution]] 2.43Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7P0Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7P0Z FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7p0z]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycmm Mycmm]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7P0Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7P0Z FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7p0z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7p0z OCA], [https://pdbe.org/7p0z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7p0z RCSB], [https://www.ebi.ac.uk/pdbsum/7p0z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7p0z ProSAT]</span></td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">espB, MMAR_5457 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=216594 MYCMM])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7p0z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7p0z OCA], [https://pdbe.org/7p0z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7p0z RCSB], [https://www.ebi.ac.uk/pdbsum/7p0z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7p0z ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	ESX-1 is a major virulence factor of Mycobacterium tuberculosis, a secretion machinery directly involved in the survival of the microorganism from the immune system defence. It disrupts the phagosome membrane of the host cell through a contact-dependent mechanism. Recently, the structure of the inner-membrane core complex of the homologous ESX-3 and ESX-5 was resolved; however, the elements involved in the secretion through the outer membrane or those acting on the host cell membrane are unknown. Protein substrates might form this missing element. Here, we describe the oligomerisation process of the ESX-1 substrate EspB, which occurs upon cleavage of its C-terminal region and is favoured by an acidic environment. Cryo-electron microscopy data shows that quaternary structure of EspB is conserved across slow growing species, but not in the fast growing M. smegmatis. EspB assembles into a channel with dimensions and characteristics suitable for the transit of ESX-1 substrates, as shown by the presence of another EspB trapped within. Our results provide insight into the structure and assembly of EspB, and suggests a possible function as a structural element of ESX-1.
		+
		+	Priming mycobacterial ESX-secreted protein B to form a channel-like structure.,Gijsbers A, Vinciauskaite V, Siroy A, Gao Y, Tria G, Mathew A, Sanchez-Puig N, Lopez-Iglesias C, Peters PJ, Ravelli RBG Curr Res Struct Biol. 2021 Jun 30;3:153-164. doi: 10.1016/j.crstbi.2021.06.001., eCollection 2021. PMID:34337436<ref>PMID:34337436</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7p0z" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Gijsbers A]]	+	[[Category: Mycmm]]
-	[[Category: Lopez-Iglesias C]]	+	[[Category: Gijsbers, A]]
-	[[Category: Mathew A]]	+	[[Category: Lopez-Iglesias, C]]
-	[[Category: Peters PJ]]	+	[[Category: Mathew, A]]
-	[[Category: Ravelli ~~RBG~~]]	+	[[Category: Peters, P J]]
-	[[Category: Sanchez-Puig N]]	+	[[Category: Ravelli, R B.G]]
-	[[Category: Siroy A]]	+	[[Category: Sanchez-Puig, N]]
-	[[Category: Tria G]]	+	[[Category: Siroy, A]]
-	[[Category: Vinciauskaite V]]	+	[[Category: Tria, G]]
-	[[Category: Ye G]]	+	[[Category: Vinciauskaite, V]]
-	[[Category: Zhang Y]]	+	[[Category: Ye, G]]
		+	[[Category: Zhang, Y]]
		+	[[Category: Cryo-em]]
		+	[[Category: Espb]]
		+	[[Category: Esx-1]]
		+	[[Category: Preferential orientation]]
		+	[[Category: Protein transport]]

OCA at 06:09, 18 August 2021

2021-08-18T06:09:00Z

←Older revision		Revision as of 06:09, 18 August 2021
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-	'''Unreleased structure'''

-	~~The entry~~ 7p0z ~~is ON HOLD~~	+	==2.43 A Mycobacterium marinum EspB.==
-		+	<StructureSection load='7p0z' size='340' side='right'caption='[[7p0z]]' scene=''>
-	~~Authors~~: ~~Gijsbers, A~~.~~, Zhang, Y~~.~~, Vinciauskaite, V~~.~~, Siroy, A~~.~~, Ye, G~~.~~, Tria, G~~.~~, Mathew, A~~., ~~Sanchez-Puig, N~~.~~, Lopez~~-~~Iglesias~~, C., ~~Peters, P~~.J., ~~Ravelli, R~~.B.G.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7P0Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7P0Z FirstGlance]. <br>
-	~~Description~~: 2.~~43 A Mycobacterium marinum EspB~~.	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7p0z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7p0z OCA], [https://pdbe.org/7p0z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7p0z RCSB], [https://www.ebi.ac.uk/pdbsum/7p0z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7p0z ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
-	[[Category: Lopez-Iglesias, C]]	+	__TOC__
-	[[Category: ~~Gijsbers,~~ A]]	+	</StructureSection>
-	[[Category: Peters~~, P.J~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Zhang, Y~~]]	+	[[Category: Gijsbers A]]
-	[[Category: ~~Ye, G~~]]	+	[[Category: Lopez-Iglesias C]]
-	[[Category: Siroy, A]]	+	[[Category: Mathew A]]
-	[[Category: ~~Vinciauskaite, V~~]]	+	[[Category: Peters PJ]]
-	[[Category: ~~Mathew, A~~]]	+	[[Category: Ravelli RBG]]
-	[[Category: ~~Tria,~~ G]]	+	[[Category: Sanchez-Puig N]]
-	[[Category: ~~Ravelli, R.B.G]]~~	+	[[Category: Siroy A]]
-	~~[[Category: Sanchez-Puig, N~~]]	+	[[Category: Tria G]]
		+	[[Category: Vinciauskaite V]]
		+	[[Category: Ye G]]
		+	[[Category: Zhang Y]]

OCA: Protected "7p0z" [edit=sysop:move=sysop]

2021-07-07T08:55:10Z

Protected "7p0z" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:55, 7 July 2021

OCA: New page: '''Unreleased structure''' The entry 7p0z is ON HOLD Authors: Gijsbers, A., Zhang, Y., Vinciauskaite, V., Siroy, A., Ye, G., Tria, G., Mathew, A., Sanchez-Puig, N., Lopez-Iglesias, C., ...

2021-07-07T08:55:09Z

New page: '''Unreleased structure''' The entry 7p0z is ON HOLD Authors: Gijsbers, A., Zhang, Y., Vinciauskaite, V., Siroy, A., Ye, G., Tria, G., Mathew, A., Sanchez-Puig, N., Lopez-Iglesias, C., ...

New page

'''Unreleased structure'''

The entry 7p0z is ON HOLD

Authors: Gijsbers, A., Zhang, Y., Vinciauskaite, V., Siroy, A., Ye, G., Tria, G., Mathew, A., Sanchez-Puig, N., Lopez-Iglesias, C., Peters, P.J., Ravelli, R.B.G.

Description: 2.43 A Mycobacterium marinum EspB.
[[Category: Unreleased Structures]]
[[Category: Lopez-Iglesias, C]]
[[Category: Gijsbers, A]]
[[Category: Peters, P.J]]
[[Category: Zhang, Y]]
[[Category: Ye, G]]
[[Category: Siroy, A]]
[[Category: Vinciauskaite, V]]
[[Category: Mathew, A]]
[[Category: Tria, G]]
[[Category: Ravelli, R.B.G]]
[[Category: Sanchez-Puig, N]]