7pkk - Revision history

OCA at 13:06, 1 February 2024

2024-02-01T13:06:11Z

←Older revision		Revision as of 13:06, 1 February 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[7pkk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_PAO1 Pseudomonas aeruginosa PAO1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7PKK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7PKK FirstGlance]. <br>		<table><tr><td colspan='2'>[[7pkk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_PAO1 Pseudomonas aeruginosa PAO1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7PKK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7PKK FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7TF:(2R,4R)-1-cyclopropylcarbonyl-4-[[(2S,4S)-4-fluoranylpyrrolidin-2-yl]carbonylamino]-N-[[4-[2-[4-(morpholin-4-ylmethyl)phenyl]ethynyl]phenyl]methyl]pyrrolidine-2-carboxamide'>7TF</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.55Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7TF:(2R,4R)-1-cyclopropylcarbonyl-4-[[(2S,4S)-4-fluoranylpyrrolidin-2-yl]carbonylamino]-N-[[4-[2-[4-(morpholin-4-ylmethyl)phenyl]ethynyl]phenyl]methyl]pyrrolidine-2-carboxamide'>7TF</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7pkk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7pkk OCA], [https://pdbe.org/7pkk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7pkk RCSB], [https://www.ebi.ac.uk/pdbsum/7pkk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7pkk ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7pkk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7pkk OCA], [https://pdbe.org/7pkk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7pkk RCSB], [https://www.ebi.ac.uk/pdbsum/7pkk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7pkk ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/LPXC_PSEAE LPXC_PSEAE]] Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.	+	[https://www.uniprot.org/uniprot/LPXC_PSEAE LPXC_PSEAE] Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 16:34, 7 September 2022

2022-09-07T16:34:55Z

←Older revision		Revision as of 16:34, 7 September 2022
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-	'''Unreleased structure'''

-	~~The entry 7pkk is ON HOLD until Paper Publication~~	+	==LpxC Inhibitors With Fluoroproline As A Novel Zinc-Binding Group Can Serve As A Novel Class of Antibiotic With Activity Against Multidrug-Resistant Gram-Negative Bacteria==
-		+	<StructureSection load='7pkk' size='340' side='right'caption='[[7pkk]], [[Resolution\|resolution]] 2.55Å' scene=''>
-	~~Authors: Ryan, M.D., Pallin, T.D., Lamers, M.B.A.C., Leonard, P.M.~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[7pkk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_PAO1 Pseudomonas aeruginosa PAO1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7PKK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7PKK FirstGlance]. <br>
-	~~Description:~~ LpxC Inhibitors With Fluoroproline As A Novel Zinc-Binding Group Can Serve As A Novel Class of Antibiotic With Activity Against Multidrug-Resistant Gram-Negative Bacteria	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7TF:(2R,4R)-1-cyclopropylcarbonyl-4-[[(2S,4S)-4-fluoranylpyrrolidin-2-yl]carbonylamino]-N-[[4-[2-[4-(morpholin-4-ylmethyl)phenyl]ethynyl]phenyl]methyl]pyrrolidine-2-carboxamide'>7TF</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7pkk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7pkk OCA], [https://pdbe.org/7pkk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7pkk RCSB], [https://www.ebi.ac.uk/pdbsum/7pkk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7pkk ProSAT]</span></td></tr>
-	[[~~Category~~: ~~Pallin~~, ~~T.D~~]]	+	</table>
-	[[~~Category~~: ~~Ryan~~, M.D]]	+	== Function ==
-	[[~~Category~~: ~~Lamers, M~~.B.A.C]]	+	[[https://www.uniprot.org/uniprot/LPXC_PSEAE LPXC_PSEAE]] Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
-	[[Category: Leonard~~, P.M~~]]	+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Pseudomonas aeruginosa PAO1]]
		+	[[Category: Lamers MBAC]]
		+	[[Category: Leonard PM]]
		+	[[Category: Pallin TD]]
		+	[[Category: Ryan MD]]

OCA at 05:29, 22 September 2021

2021-09-22T05:29:10Z

←Older revision		Revision as of 05:29, 22 September 2021
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7pkk is ON HOLD	+	The entry 7pkk is ON HOLD until Paper Publication

	Authors: Ryan, M.D., Pallin, T.D., Lamers, M.B.A.C., Leonard, P.M.		Authors: Ryan, M.D., Pallin, T.D., Lamers, M.B.A.C., Leonard, P.M.

OCA: Protected "7pkk" [edit=sysop:move=sysop]

2021-09-08T07:35:11Z

Protected "7pkk" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:35, 8 September 2021

OCA: New page: '''Unreleased structure''' The entry 7pkk is ON HOLD Authors: Ryan, M.D., Pallin, T.D., Lamers, M.B.A.C., Leonard, P.M. Description: LpxC Inhibitors With Fluoroproline As A Novel Zinc-...

2021-09-08T07:35:10Z

New page: '''Unreleased structure''' The entry 7pkk is ON HOLD Authors: Ryan, M.D., Pallin, T.D., Lamers, M.B.A.C., Leonard, P.M. Description: LpxC Inhibitors With Fluoroproline As A Novel Zinc-...

New page

'''Unreleased structure'''

The entry 7pkk is ON HOLD

Authors: Ryan, M.D., Pallin, T.D., Lamers, M.B.A.C., Leonard, P.M.

Description: LpxC Inhibitors With Fluoroproline As A Novel Zinc-Binding Group Can Serve As A Novel Class of Antibiotic With Activity Against Multidrug-Resistant Gram-Negative Bacteria
[[Category: Unreleased Structures]]
[[Category: Pallin, T.D]]
[[Category: Ryan, M.D]]
[[Category: Lamers, M.B.A.C]]
[[Category: Leonard, P.M]]