7psi - Revision history

OCA at 13:08, 1 February 2024

2024-02-01T13:08:35Z

←Older revision		Revision as of 13:08, 1 February 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[7psi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Acidobacterium_capsulatum_ATCC_51196 Acidobacterium capsulatum ATCC 51196]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7PSI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7PSI FirstGlance]. <br>		<table><tr><td colspan='2'>[[7psi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Acidobacterium_capsulatum_ATCC_51196 Acidobacterium capsulatum ATCC 51196]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7PSI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7PSI FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8I4:(2R,3S,5R,6R)-2,3,4,5,6-pentakis(oxidanyl)cyclohexane-1-carboxylic+acid'>8I4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.25Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8I4:(2R,3S,5R,6R)-2,3,4,5,6-pentakis(oxidanyl)cyclohexane-1-carboxylic+acid'>8I4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7psi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7psi OCA], [https://pdbe.org/7psi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7psi RCSB], [https://www.ebi.ac.uk/pdbsum/7psi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7psi ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7psi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7psi OCA], [https://pdbe.org/7psi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7psi RCSB], [https://www.ebi.ac.uk/pdbsum/7psi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7psi ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/C1F2K5_ACIC5 C1F2K5_ACIC5]]	+	[https://www.uniprot.org/uniprot/C1F2K5_ACIC5 C1F2K5_ACIC5]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 03:10, 8 September 2022

2022-09-08T03:10:49Z

←Older revision		Revision as of 03:10, 8 September 2022
Line 1:		Line 1:

	==Crystal structure of beta-glucuronidase from Acidobacterium capsulatum in complex with covalent inhibitor ME727==		==Crystal structure of beta-glucuronidase from Acidobacterium capsulatum in complex with covalent inhibitor ME727==
-	<StructureSection load='7psi' size='340' side='right'caption='[[7psi]]' scene=''>	+	<StructureSection load='7psi' size='340' side='right'caption='[[7psi]], [[Resolution\|resolution]] 1.25Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7PSI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7PSI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7psi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Acidobacterium_capsulatum_ATCC_51196 Acidobacterium capsulatum ATCC 51196]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7PSI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7PSI FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7psi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7psi OCA], [https://pdbe.org/7psi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7psi RCSB], [https://www.ebi.ac.uk/pdbsum/7psi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7psi ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8I4:(2R,3S,5R,6R)-2,3,4,5,6-pentakis(oxidanyl)cyclohexane-1-carboxylic+acid'>8I4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7psi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7psi OCA], [https://pdbe.org/7psi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7psi RCSB], [https://www.ebi.ac.uk/pdbsum/7psi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7psi ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[https://www.uniprot.org/uniprot/C1F2K5_ACIC5 C1F2K5_ACIC5]]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Heparan sulfate proteoglycans (HSPGs) mediate essential interactions throughout the extracellular matrix (ECM), providing signals that regulate cellular growth and development. Altered HSPG composition during tumorigenesis strongly aids cancer progression. Heparanase (HPSE) is the principal enzyme responsible for extracellular heparan sulfate catabolism and is markedly up-regulated in aggressive cancers. HPSE overactivity degrades HSPGs within the ECM, facilitating metastatic dissemination and releasing mitogens that drive cellular proliferation. Reducing extracellular HPSE activity reduces cancer growth, but few effective inhibitors are known, and none are clinically approved. Inspired by the natural glycosidase inhibitor cyclophellitol, we developed nanomolar mechanism-based, irreversible HPSE inhibitors that are effective within physiological environments. Application of cyclophellitol-derived HPSE inhibitors reduces cancer aggression in cellulo and significantly ameliorates murine metastasis. Mechanism-based irreversible HPSE inhibition is an unexplored anticancer strategy. We demonstrate the feasibility of such compounds to control pathological HPSE-driven malignancies.
		+
		+	Mechanism-based heparanase inhibitors reduce cancer metastasis in vivo.,de Boer C, Armstrong Z, Lit VAJ, Barash U, Ruijgrok G, Boyango I, Weitzenberg MM, Schroder SP, Sarris AJC, Meeuwenoord NJ, Bule P, Kayal Y, Ilan N, Codee JDC, Vlodavsky I, Overkleeft HS, Davies GJ, Wu L Proc Natl Acad Sci U S A. 2022 Aug 2;119(31):e2203167119. doi:, 10.1073/pnas.2203167119. Epub 2022 Jul 26. PMID:35881786<ref>PMID:35881786</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7psi" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Acidobacterium capsulatum ATCC 51196]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Armstrong Z]]		[[Category: Armstrong Z]]
	[[Category: Davies GJ]]		[[Category: Davies GJ]]
	[[Category: Wu L]]		[[Category: Wu L]]

OCA at 04:51, 3 August 2022

2022-08-03T04:51:32Z

←Older revision		Revision as of 04:51, 3 August 2022
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry 7psi is ON HOLD~~	+	==Crystal structure of beta-glucuronidase from Acidobacterium capsulatum in complex with covalent inhibitor ME727==
-		+	<StructureSection load='7psi' size='340' side='right'caption='[[7psi]]' scene=''>
-	~~Authors: Armstrong, Z., Wu, L., Davies, G.J.~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7PSI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7PSI FirstGlance]. <br>
-	~~Description:~~ Crystal structure of beta-glucuronidase from Acidobacterium capsulatum in complex with covalent inhibitor ME727	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7psi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7psi OCA], [https://pdbe.org/7psi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7psi RCSB], [https://www.ebi.ac.uk/pdbsum/7psi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7psi ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
-	[[Category: ~~Wu, L~~]]	+	__TOC__
-	[[Category: Davies~~, G.J~~]]	+	</StructureSection>
-	[[Category: ~~Armstrong, Z~~]]	+	[[Category: Large Structures]]
		+	[[Category: Armstrong Z]]
		+	[[Category: Davies GJ]]
		+	[[Category: Wu L]]

OCA: Protected "7psi" [edit=sysop:move=sysop]

2021-09-29T07:41:16Z

Protected "7psi" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:41, 29 September 2021

OCA: New page: '''Unreleased structure''' The entry 7psi is ON HOLD Authors: Armstrong, Z., Wu, L., Davies, G.J. Description: Crystal structure of beta-glucuronidase from Acidobacterium capsulatum in...

2021-09-29T07:41:15Z

New page: '''Unreleased structure''' The entry 7psi is ON HOLD Authors: Armstrong, Z., Wu, L., Davies, G.J. Description: Crystal structure of beta-glucuronidase from Acidobacterium capsulatum in...

New page

'''Unreleased structure'''

The entry 7psi is ON HOLD

Authors: Armstrong, Z., Wu, L., Davies, G.J.

Description: Crystal structure of beta-glucuronidase from Acidobacterium capsulatum in complex with covalent inhibitor ME727
[[Category: Unreleased Structures]]
[[Category: Wu, L]]
[[Category: Davies, G.J]]
[[Category: Armstrong, Z]]