7q16 - Revision history

OCA at 13:12, 1 February 2024

2024-02-01T13:12:15Z

←Older revision		Revision as of 13:12, 1 February 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[7q16]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7Q16 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7Q16 FirstGlance]. <br>		<table><tr><td colspan='2'>[[7q16]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7Q16 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7Q16 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.356Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7q16 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7q16 OCA], [https://pdbe.org/7q16 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7q16 RCSB], [https://www.ebi.ac.uk/pdbsum/7q16 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7q16 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7q16 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7q16 OCA], [https://pdbe.org/7q16 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7q16 RCSB], [https://www.ebi.ac.uk/pdbsum/7q16 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7q16 ProSAT]</span></td></tr>
	</table>		</table>

OCA at 06:24, 26 October 2022

2022-10-26T06:24:09Z

←Older revision		Revision as of 06:24, 26 October 2022
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	==Human 14-3-3 zeta fused to the BAD peptide including phosphoserine-74==		==Human 14-3-3 zeta fused to the BAD peptide including phosphoserine-74==
-	<StructureSection load='7q16' size='340' side='right'caption='[[7q16]]' scene=''>	+	<StructureSection load='7q16' size='340' side='right'caption='[[7q16]], [[Resolution\|resolution]] 2.36Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7Q16 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7Q16 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7q16]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7Q16 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7Q16 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7q16 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7q16 OCA], [https://pdbe.org/7q16 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7q16 RCSB], [https://www.ebi.ac.uk/pdbsum/7q16 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7q16 ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7q16 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7q16 OCA], [https://pdbe.org/7q16 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7q16 RCSB], [https://www.ebi.ac.uk/pdbsum/7q16 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7q16 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/1433Z_HUMAN 1433Z_HUMAN] Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.<ref>PMID:9360956</ref> <ref>PMID:14578935</ref> <ref>PMID:15071501</ref> <ref>PMID:15644438</ref> <ref>PMID:16376338</ref> [https://www.uniprot.org/uniprot/BAD_HUMAN BAD_HUMAN] Promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X(L), but not that of Bcl-2 (By similarity). Appears to act as a link between growth factor receptor signaling and the apoptotic pathways.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Several signaling pathways control phosphorylation of the proapoptotic protein BAD and its phosphorylation-dependent association with 14-3-3 proteins in the cytoplasm. The stability of the 14-3-3/BAD complex determines the cell fate: unphosphorylated BAD escapes from 14-3-3, migrates to the mitochondria and initiates apoptosis. While the 14-3-3/BAD interaction represents a promising drug target, it lacks structural characterization. Among several phosphosites identified in vivo, Ser75 and Ser99 of human BAD match the consensus sequence RXXpSXP recognized by 14-3-3 and, therefore, represent canonical 14-3-3-binding sites. Yet, BAD contains other serines phosphorylatable in vivo, whose role is less understood. Here, we report a 2.36 A crystal structure of 14-3-3zeta complexed with a BAD fragment which includes residues Ser74 and Ser75, both being substrates for protein kinases. While the BAD peptide is anchored to 14-3-3 by phosphoserine as expected, the BAD peptide was unexpectedly phosphorylated at Ser74 instead of Ser75, revealing noncanonical binding within the amphipathic groove and leading to a one-step positional shift and reorganization of the interface. This observation exemplifies plasticity of the amphipathic 14-3-3 groove in accommodating various peptides and suggests the redundancy of Ser74 and Ser75 phosphosites with respect to binding of BAD to 14-3-3.
		+
		+	Crystal structure of human 14-3-3zeta complexed with the noncanonical phosphopeptide from proapoptotic BAD.,Sluchanko NN, Tugaeva KV, Gushchin I, Remeeva A, Kovalev K, Cooley RB Biochem Biophys Res Commun. 2021 Oct 26;583:100-105. doi:, 10.1016/j.bbrc.2021.10.053. PMID:34735870<ref>PMID:34735870</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7q16" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[14-3-3 protein 3D structures\|14-3-3 protein 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Cooley RB]]		[[Category: Cooley RB]]

OCA at 13:39, 17 November 2021

2021-11-17T13:39:11Z

←Older revision		Revision as of 13:39, 17 November 2021
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-	'''Unreleased structure'''

-	~~The entry~~ 7q16 is ~~ON HOLD~~	+	==Human 14-3-3 zeta fused to the BAD peptide including phosphoserine-74==
-		+	<StructureSection load='7q16' size='340' side='right'caption='[[7q16]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7Q16 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7Q16 FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7q16 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7q16 OCA], [https://pdbe.org/7q16 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7q16 RCSB], [https://www.ebi.ac.uk/pdbsum/7q16 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7q16 ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Cooley RB]]
		+	[[Category: Gushchin I]]
		+	[[Category: Kovalev K]]
		+	[[Category: Remeeva A]]
		+	[[Category: Sluchanko NN]]
		+	[[Category: Tugaeva KV]]

OCA: Protected "7q16" [edit=sysop:move=sysop]

2021-10-27T12:36:04Z

Protected "7q16" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:36, 27 October 2021

OCA: New page: '''Unreleased structure''' The entry 7q16 is ON HOLD Authors: Description: Category: Unreleased Structures

2021-10-27T12:36:02Z

New page: '''Unreleased structure''' The entry 7q16 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7q16 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]