7q3z - Revision history

OCA at 13:13, 1 February 2024

2024-02-01T13:13:36Z

←Older revision		Revision as of 13:13, 1 February 2024
Line 3:		Line 3:
	<StructureSection load='7q3z' size='340' side='right'caption='[[7q3z]], [[Resolution\|resolution]] 1.85Å' scene=''>		<StructureSection load='7q3z' size='340' side='right'caption='[[7q3z]], [[Resolution\|resolution]] 1.85Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[7q3z]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7Q3Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7Q3Z FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7q3z]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7Q3Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7Q3Z FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=NA:SODIUM+ION'>NA</scene>~~, ~~<scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.85Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height~~: ~~3em;~~'>~~[[6rr9\|6rr9]]~~</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7q3z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7q3z OCA], [https://pdbe.org/7q3z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7q3z RCSB], [https://www.ebi.ac.uk/pdbsum/7q3z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7q3z ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7q3z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7q3z OCA], [https://pdbe.org/7q3z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7q3z RCSB], [https://www.ebi.ac.uk/pdbsum/7q3z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7q3z ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/SLFN5_HUMAN SLFN5_HUMAN]] May have a role in hematopoietic cell differentiation.	+	[https://www.uniprot.org/uniprot/SLFN5_HUMAN SLFN5_HUMAN] May have a role in hematopoietic cell differentiation.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Huber, E]]	+	[[Category: Huber E]]
-	[[Category: Lammens, K]]	+	[[Category: Lammens K]]
-	~~[[Category: Dna binding protein]]~~	+
-	~~[[Category: Rna-binding]]~~	+
-	~~[[Category: Zinc-finger protein~~]]	+

OCA at 07:15, 2 February 2022

2022-02-02T07:15:26Z

←Older revision		Revision as of 07:15, 2 February 2022
Line 1:		Line 1:

	==DNA/RNA binding protein==		==DNA/RNA binding protein==
-	<StructureSection load='7q3z' size='340' side='right'caption='[[7q3z]]' scene=''>	+	<StructureSection load='7q3z' size='340' side='right'caption='[[7q3z]], [[Resolution\|resolution]] 1.85Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7Q3Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7Q3Z FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7q3z]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7Q3Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7Q3Z FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7q3z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7q3z OCA], [https://pdbe.org/7q3z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7q3z RCSB], [https://www.ebi.ac.uk/pdbsum/7q3z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7q3z ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[6rr9\|6rr9]]</div></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7q3z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7q3z OCA], [https://pdbe.org/7q3z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7q3z RCSB], [https://www.ebi.ac.uk/pdbsum/7q3z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7q3z ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[https://www.uniprot.org/uniprot/SLFN5_HUMAN SLFN5_HUMAN]] May have a role in hematopoietic cell differentiation.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The Schlafen family belongs to the interferon-stimulated genes and its members are involved in cell cycle regulation, T cell quiescence, inhibition of viral replication, DNA-repair and tRNA processing. Here, we present the cryo-EM structure of full-length human Schlafen 5 (SLFN5) and the high-resolution crystal structure of the highly conserved N-terminal core domain. We show that the core domain does not resemble an ATPase-like fold and neither binds nor hydrolyzes ATP. SLFN5 binds tRNA as well as single- and double-stranded DNA, suggesting a potential role in transcriptional regulation. Unlike rat Slfn13 or human SLFN11, human SLFN5 did not cleave tRNA. Based on the structure, we identified two residues in proximity to the zinc finger motif that decreased DNA binding when mutated. These results indicate that Schlafen proteins have divergent enzymatic functions and provide a structural platform for future biochemical and genetic studies.
		+
		+	Structural and biochemical characterization of human Schlafen 5.,Metzner FJ, Huber E, Hopfner KP, Lammens K Nucleic Acids Res. 2022 Jan 25;50(2):1147-1161. doi: 10.1093/nar/gkab1278. PMID:35037067<ref>PMID:35037067</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7q3z" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Huber E]]	+	[[Category: Huber, E]]
-	[[Category: Lammens K]]	+	[[Category: Lammens, K]]
		+	[[Category: Dna binding protein]]
		+	[[Category: Rna-binding]]
		+	[[Category: Zinc-finger protein]]

OCA at 07:02, 27 January 2022

2022-01-27T07:02:44Z

←Older revision		Revision as of 07:02, 27 January 2022
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 7q3z ~~is ON HOLD until Paper Publication~~	+	==DNA/RNA binding protein==
-		+	<StructureSection load='7q3z' size='340' side='right'caption='[[7q3z]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7Q3Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7Q3Z FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7q3z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7q3z OCA], [https://pdbe.org/7q3z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7q3z RCSB], [https://www.ebi.ac.uk/pdbsum/7q3z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7q3z ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Huber E]]
		+	[[Category: Lammens K]]

OCA at 12:02, 17 November 2021

2021-11-17T12:02:27Z

←Older revision		Revision as of 12:02, 17 November 2021
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7q3z is ON HOLD	+	The entry 7q3z is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7q3z" [edit=sysop:move=sysop]

2021-11-10T05:09:27Z

Protected "7q3z" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:09, 10 November 2021

OCA: New page: '''Unreleased structure''' The entry 7q3z is ON HOLD Authors: Description: Category: Unreleased Structures

2021-11-10T05:09:26Z

New page: '''Unreleased structure''' The entry 7q3z is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7q3z is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]