7qar - Revision history

OCA at 07:56, 7 February 2024

2024-02-07T07:56:55Z

←Older revision		Revision as of 07:56, 7 February 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[7qar]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Aspergillus_flavus Aspergillus flavus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7QAR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7QAR FirstGlance]. <br>		<table><tr><td colspan='2'>[[7qar]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Aspergillus_flavus Aspergillus flavus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7QAR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7QAR FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=XDS:(5S)-5-(DIOXIDANYL)-9-METHYL-7H-PURINE-2,6,8-TRIONE'>XDS</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.3Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=XDS:(5S)-5-(DIOXIDANYL)-9-METHYL-7H-PURINE-2,6,8-TRIONE'>XDS</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7qar FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7qar OCA], [https://pdbe.org/7qar PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7qar RCSB], [https://www.ebi.ac.uk/pdbsum/7qar PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7qar ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7qar FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7qar OCA], [https://pdbe.org/7qar PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7qar RCSB], [https://www.ebi.ac.uk/pdbsum/7qar PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7qar ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/URIC_ASPFL URIC_ASPFL] Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin.		[https://www.uniprot.org/uniprot/URIC_ASPFL URIC_ASPFL] Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin.
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Serial crystallography at conventional synchrotron light sources (SSX) offers the possibility to routinely collect data at room temperature using micrometre-sized crystals of biological macromolecules. However, SSX data collection is not yet as routine and currently takes significantly longer than the standard rotation series cryo-crystallography. Thus, its use for high-throughput approaches, such as fragment-based drug screening, where the possibility to measure at physio-logical temperatures would be a great benefit, is impaired. On the way to high-throughput SSX using a conveyor belt based sample delivery system - the CFEL TapeDrive - with three different proteins of biological relevance (Klebsiella pneumoniae CTX-M-14 beta-lactamase, Nectria haematococca xylanase GH11 and Aspergillus flavus urate oxidase), it is shown here that complete datasets can be collected in less than a minute and only minimal amounts of sample are required.
-
-	Rapid and efficient room-temperature serial synchrotron crystallography using the CFEL TapeDrive.,Zielinski KA, Prester A, Andaleeb H, Bui S, Yefanov O, Catapano L, Henkel A, Wiedorn MO, Lorbeer O, Crosas E, Meyer J, Mariani V, Domaracky M, White TA, Fleckenstein H, Sarrou I, Werner N, Betzel C, Rohde H, Aepfelbacher M, Chapman HN, Perbandt M, Steiner RA, Oberthuer D IUCrJ. 2022 Oct 31;9(Pt 6):778-791. doi: 10.1107/S2052252522010193. eCollection , 2022 Nov 1. PMID:36381150<ref>PMID:36381150</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 7qar" style="background-color:#fffaf0;"></div>
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 16:56, 26 April 2023

2023-04-26T16:56:27Z

←Older revision		Revision as of 16:56, 26 April 2023
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-	'''Unreleased structure'''

-	~~The entry~~ 7qar is ~~ON HOLD until Paper~~ Publication	+	==Serial crystallography structure of cofactor-free urate oxidase in complex with the 5-peroxo derivative of 9-methyl uric acid at room temperature==
		+	<StructureSection load='7qar' size='340' side='right'caption='[[7qar]], [[Resolution\|resolution]] 2.30Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[7qar]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Aspergillus_flavus Aspergillus flavus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7QAR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7QAR FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=XDS:(5S)-5-(DIOXIDANYL)-9-METHYL-7H-PURINE-2,6,8-TRIONE'>XDS</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7qar FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7qar OCA], [https://pdbe.org/7qar PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7qar RCSB], [https://www.ebi.ac.uk/pdbsum/7qar PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7qar ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/URIC_ASPFL URIC_ASPFL] Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Serial crystallography at conventional synchrotron light sources (SSX) offers the possibility to routinely collect data at room temperature using micrometre-sized crystals of biological macromolecules. However, SSX data collection is not yet as routine and currently takes significantly longer than the standard rotation series cryo-crystallography. Thus, its use for high-throughput approaches, such as fragment-based drug screening, where the possibility to measure at physio-logical temperatures would be a great benefit, is impaired. On the way to high-throughput SSX using a conveyor belt based sample delivery system - the CFEL TapeDrive - with three different proteins of biological relevance (Klebsiella pneumoniae CTX-M-14 beta-lactamase, Nectria haematococca xylanase GH11 and Aspergillus flavus urate oxidase), it is shown here that complete datasets can be collected in less than a minute and only minimal amounts of sample are required.

-	~~Authors~~:	+	Rapid and efficient room-temperature serial synchrotron crystallography using the CFEL TapeDrive.,Zielinski KA, Prester A, Andaleeb H, Bui S, Yefanov O, Catapano L, Henkel A, Wiedorn MO, Lorbeer O, Crosas E, Meyer J, Mariani V, Domaracky M, White TA, Fleckenstein H, Sarrou I, Werner N, Betzel C, Rohde H, Aepfelbacher M, Chapman HN, Perbandt M, Steiner RA, Oberthuer D IUCrJ. 2022 Oct 31;9(Pt 6):778-791. doi: 10.1107/S2052252522010193. eCollection , 2022 Nov 1. PMID:36381150<ref>PMID:36381150</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 7qar" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Aspergillus flavus]]
		+	[[Category: Large Structures]]
		+	[[Category: Bui S]]
		+	[[Category: Catapano L]]
		+	[[Category: Murshudov GN]]
		+	[[Category: Oberthuer D]]
		+	[[Category: Steiner RA]]
		+	[[Category: Yefanov O]]
		+	[[Category: Zielinski K]]

OCA at 05:03, 1 December 2021

2021-12-01T05:03:45Z

←Older revision		Revision as of 05:03, 1 December 2021
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7qar is ON HOLD	+	The entry 7qar is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7qar" [edit=sysop:move=sysop]

2021-11-24T10:52:31Z

Protected "7qar" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:52, 24 November 2021

OCA: New page: '''Unreleased structure''' The entry 7qar is ON HOLD Authors: Description: Category: Unreleased Structures

2021-11-24T10:52:30Z

New page: '''Unreleased structure''' The entry 7qar is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7qar is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]