7qf6 - Revision history

OCA at 07:53, 1 May 2024

2024-05-01T07:53:31Z

←Older revision		Revision as of 07:53, 1 May 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[7qf6]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Aspergillus_fumigatus Aspergillus fumigatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7QF6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7QF6 FirstGlance]. <br>		<table><tr><td colspan='2'>[[7qf6]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Aspergillus_fumigatus Aspergillus fumigatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7QF6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7QF6 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=SCN:THIOCYANATE+ION'>SCN</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.87Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=SCN:THIOCYANATE+ION'>SCN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7qf6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7qf6 OCA], [https://pdbe.org/7qf6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7qf6 RCSB], [https://www.ebi.ac.uk/pdbsum/7qf6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7qf6 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7qf6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7qf6 OCA], [https://pdbe.org/7qf6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7qf6 RCSB], [https://www.ebi.ac.uk/pdbsum/7qf6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7qf6 ProSAT]</span></td></tr>
	</table>		</table>

OCA at 09:58, 14 December 2022

2022-12-14T09:58:51Z

←Older revision		Revision as of 09:58, 14 December 2022
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-	'''Unreleased structure'''

-	~~The entry~~ 7qf6 is ~~ON HOLD until Paper Publication~~	+	==N(5)-hydroxyornithine:cis-anhydromevalonyl coenzyme A-N(5)-transacylase sidF==
-		+	<StructureSection load='7qf6' size='340' side='right'caption='[[7qf6]], [[Resolution\|resolution]] 1.87Å' scene=''>
-	~~Authors~~: ~~Poonsiri~~, T., ~~Demitri~~, N., ~~Stefano~~, B.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[7qf6]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Aspergillus_fumigatus Aspergillus fumigatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7QF6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7QF6 FirstGlance]. <br>
-	~~Description~~: N(5)-hydroxyornithine~~:cis~~-~~anhydromevalonyl coenzyme A~~-N(5)-transacylase sidF	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=SCN:THIOCYANATE+ION'>SCN</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7qf6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7qf6 OCA], [https://pdbe.org/7qf6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7qf6 RCSB], [https://www.ebi.ac.uk/pdbsum/7qf6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7qf6 ProSAT]</span></td></tr>
-	[[Category: ~~Stefano, B~~]]	+	</table>
-	[[Category: Poonsiri, T]]	+	== Function ==
-	[[Category: ~~Demitri, N~~]]	+	[https://www.uniprot.org/uniprot/SIDF_ASPFU SIDF_ASPFU] Hydroxyornithine transacylase; part of the siderophore biosynthetic pathway (PubMed:17845073, PubMed:23617799). Aspergillus fumigatus produces 4 types of siderophores, low-molecular-mass iron chelators, including excreted fusarinine C (FsC) and triacetylfusarinine C (TAFC) for iron uptake and intacellular ferricrocin (FC) for hyphal and hydroxyferricrocin (HFC) for conidial iron distribution and storage. TAFC consists of 3 N(2)-acetyl-N(5)-anhydromevalonyl-N(5)-hydroxyornithine residues cyclically linked by ester bonds; FC is a cyclic hexapeptide with the structure Gly-Ser-Gly-(N(5)-acetyl-N(5)-hydroxyornithine)x3. The biosynthesis of all four siderophores depends on the hydroxylation of ornithine, catalyzed by the monooxygenase sidA (PubMed:15504822, PubMed:16113265). Subsequently, the pathways for biosynthesis of extra- and intracellular siderophores split (PubMed:17845073). For biosynthesis of extracellular siderophores, the transacylase sidF transfers anhydromevalonyl to N(5)-hydroxyornithine (PubMed:17845073). The required anhydromevalonyl-CoA moiety is derived from mevalonate by CoA ligation and dehydration catalyzed by sidI and sidH respectively (PubMed:22106303). The acetylation of N(5)-hydroxyornithine for FC biosynthesis involves the constitutively expressed sidL (PubMed:21622789). FC is hydroxylated to HFC by an as yet uncharacterized enzyme during conidiation (PubMed:17845073). Assembly of fusarinine C (FsC) and FC is catalyzed by two different nonribosomal peptide synthetases (NRPS), sidD and sidC respectively (PubMed:17845073). Subsequently, sidG catalyzes N2-acetylation of FsC for forming TAFC (PubMed:17845073). Both extra- and intracellular siderophores are crucial for growth during iron limitation and virulence (PubMed:16113265).<ref>PMID:15504822</ref> <ref>PMID:16113265</ref> <ref>PMID:17845073</ref> <ref>PMID:21622789</ref> <ref>PMID:22106303</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Aspergillus fumigatus]]
		+	[[Category: Large Structures]]
		+	[[Category: Demitri N]]
		+	[[Category: Poonsiri T]]
		+	[[Category: Stefano B]]

OCA at 08:28, 12 January 2022

2022-01-12T08:28:39Z

←Older revision		Revision as of 08:28, 12 January 2022
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7qf6 is ON HOLD	+	The entry 7qf6 is ON HOLD until Paper Publication

	Authors: Poonsiri, T., Demitri, N., Stefano, B.		Authors: Poonsiri, T., Demitri, N., Stefano, B.

OCA: Protected "7qf6" [edit=sysop:move=sysop]

2021-12-15T15:33:21Z

Protected "7qf6" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:33, 15 December 2021

OCA: New page: '''Unreleased structure''' The entry 7qf6 is ON HOLD Authors: Poonsiri, T., Demitri, N., Stefano, B. Description: N(5)-hydroxyornithine:cis-anhydromevalonyl coenzyme A-N(5)-transacylas...

2021-12-15T15:33:20Z

New page: '''Unreleased structure''' The entry 7qf6 is ON HOLD Authors: Poonsiri, T., Demitri, N., Stefano, B. Description: N(5)-hydroxyornithine:cis-anhydromevalonyl coenzyme A-N(5)-transacylas...

New page

'''Unreleased structure'''

The entry 7qf6 is ON HOLD

Authors: Poonsiri, T., Demitri, N., Stefano, B.

Description: N(5)-hydroxyornithine:cis-anhydromevalonyl coenzyme A-N(5)-transacylase sidF
[[Category: Unreleased Structures]]
[[Category: Stefano, B]]
[[Category: Poonsiri, T]]
[[Category: Demitri, N]]