7qgj - Revision history

OCA at 07:53, 1 May 2024

2024-05-01T07:53:40Z

←Older revision		Revision as of 07:53, 1 May 2024
Line 1:		Line 1:

	==Apo structure of BIR2 Domain of BIRC2==		==Apo structure of BIR2 Domain of BIRC2==
-	<StructureSection load='7qgj' size='340' side='right'caption='[[7qgj]]' scene=''>	+	<StructureSection load='7qgj' size='340' side='right'caption='[[7qgj]], [[Resolution\|resolution]] 1.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7QGJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7QGJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7qgj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7QGJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7QGJ FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7qgj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7qgj OCA], [https://pdbe.org/7qgj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7qgj RCSB], [https://www.ebi.ac.uk/pdbsum/7qgj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7qgj ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.3Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7qgj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7qgj OCA], [https://pdbe.org/7qgj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7qgj RCSB], [https://www.ebi.ac.uk/pdbsum/7qgj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7qgj ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/BIRC2_HUMAN BIRC2_HUMAN] Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling, and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, TRAF2, DIABLO/SMAC, MAP3K14/NIK, MAP3K5/ASK1, IKBKG/NEMO and MXD1/MAD1. Can also function as an E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway, targeting effector caspases for neddylation and inactivation. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8. Can stimulate the transcriptional activity of E2F1. Plays a role in the modulation of the cell cycle.<ref>PMID:15665297</ref> <ref>PMID:18082613</ref> <ref>PMID:21145488</ref> <ref>PMID:21653699</ref> <ref>PMID:21931591</ref>
		+
		+	==See Also==
		+	*[[Ubiquitin protein ligase 3D structures\|Ubiquitin protein ligase 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Farges F]]		[[Category: Farges F]]

OCA at 07:25, 9 February 2022

2022-02-09T07:25:22Z

←Older revision		Revision as of 07:25, 9 February 2022
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-	'''Unreleased structure'''

-	~~The entry~~ 7qgj ~~is ON HOLD~~	+	==Apo structure of BIR2 Domain of BIRC2==
-		+	<StructureSection load='7qgj' size='340' side='right'caption='[[7qgj]]' scene=''>
-	~~Authors~~: ~~Kraemer, A~~.~~, Farges, F~~., ~~Schwalm, M~~.P., ~~Saxena, K~~., ~~Knapp~~, S., ~~Structural Genomics Consortium (SGC)~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7QGJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7QGJ FirstGlance]. <br>
-	~~Description: Apo structure of BIR2 Domain of BIRC2~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7qgj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7qgj OCA], [https://pdbe.org/7qgj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7qgj RCSB], [https://www.ebi.ac.uk/pdbsum/7qgj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7qgj ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
-	[[Category: Farges, F]]	+	__TOC__
-	[[Category: Knapp, S]]	+	</StructureSection>
-	[[Category: ~~Saxena, K~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Schwalm, M.P~~]]	+	[[Category: Farges F]]
-	[[Category: ~~Structural Genomics Consortium (Sgc)~~]]	+	[[Category: Knapp S]]
-	[[Category: ~~Kraemer, A~~]]	+	[[Category: Kraemer A]]
		+	[[Category: Preuss F]]
		+	[[Category: Saxena K]]
		+	[[Category: Schwalm MP]]

OCA: Protected "7qgj" [edit=sysop:move=sysop]

2021-12-15T15:36:01Z

Protected "7qgj" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:36, 15 December 2021

OCA: New page: '''Unreleased structure''' The entry 7qgj is ON HOLD Authors: Kraemer, A., Farges, F., Schwalm, M.P., Saxena, K., Knapp, S., Structural Genomics Consortium (SGC) Description: Apo struc...

2021-12-15T15:35:59Z

New page: '''Unreleased structure''' The entry 7qgj is ON HOLD Authors: Kraemer, A., Farges, F., Schwalm, M.P., Saxena, K., Knapp, S., Structural Genomics Consortium (SGC) Description: Apo struc...

New page

'''Unreleased structure'''

The entry 7qgj is ON HOLD

Authors: Kraemer, A., Farges, F., Schwalm, M.P., Saxena, K., Knapp, S., Structural Genomics Consortium (SGC)

Description: Apo structure of BIR2 Domain of BIRC2
[[Category: Unreleased Structures]]
[[Category: Farges, F]]
[[Category: Knapp, S]]
[[Category: Saxena, K]]
[[Category: Schwalm, M.P]]
[[Category: Structural Genomics Consortium (Sgc)]]
[[Category: Kraemer, A]]