7quu - Revision history

OCA at 20:23, 16 November 2022

2022-11-16T20:23:35Z

←Older revision		Revision as of 20:23, 16 November 2022
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	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/YFPE_SCHPO YFPE_SCHPO]]	+	[https://www.uniprot.org/uniprot/YFPE_SCHPO YFPE_SCHPO]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 18:38, 7 September 2022

2022-09-07T18:38:27Z

←Older revision		Revision as of 18:38, 7 September 2022
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	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/YFPE_SCHPO YFPE_SCHPO]]		[[https://www.uniprot.org/uniprot/YFPE_SCHPO YFPE_SCHPO]]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	To eliminate specific or aberrant transcripts, eukaryotes use nuclear RNA-targeting complexes that deliver them to the exosome for degradation. S. pombe MTREC, and its human counterpart PAXT, are key players in this mechanism but inner workings of these complexes are not understood in sufficient detail. Here, we present an NMR structure of an MTREC scaffold protein Red1 helix-turn-helix domain bound to the Iss10 N-terminus and show this interaction is required for proper cellular growth and meiotic mRNA degradation. We also report a crystal structure of a Red1-Ars2 complex explaining mutually exclusive interactions of hARS2 with various ED/EGEI/L motif-possessing RNA regulators, including hZFC3H1 of PAXT, hFLASH or hNCBP3. Finally, we show that both Red1 and hZFC3H1 homo-dimerize via their coiled-coil regions indicating that MTREC and PAXT likely function as dimers. Our results, combining structures of three Red1 interfaces with in vivo studies, provide mechanistic insights into conserved features of MTREC/PAXT architecture.
		+
		+	Structural analysis of Red1 as a conserved scaffold of the RNA-targeting MTREC/PAXT complex.,Foucher AE, Touat-Todeschini L, Juarez-Martinez AB, Rakitch A, Laroussi H, Karczewski C, Acajjaoui S, Soler-Lopez M, Cusack S, Mackereth CD, Verdel A, Kadlec J Nat Commun. 2022 Aug 24;13(1):4969. doi: 10.1038/s41467-022-32542-3. PMID:36002457<ref>PMID:36002457</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7quu" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 16:35, 7 September 2022

2022-09-07T16:35:53Z

←Older revision		Revision as of 16:35, 7 September 2022
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-	'''Unreleased structure'''

-	~~The entry~~ 7quu ~~is ON HOLD until Paper Publication~~	+	==Red1-Iss10 complex==
-		+	<StructureSection load='7quu' size='340' side='right'caption='[[7quu]]' scene=''>
-	~~Authors~~: ~~Mackereth~~, C.D., ~~Kadlec~~, J., ~~Laroussi~~, H.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[7quu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7QUU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7QUU FirstGlance]. <br>
-	~~Description~~: ~~Red1-Iss10 complex~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7quu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7quu OCA], [https://pdbe.org/7quu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7quu RCSB], [https://www.ebi.ac.uk/pdbsum/7quu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7quu ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
-	[[Category: Kadlec, J]]	+	== Function ==
-	[[Category: Laroussi, H]]	+	[[https://www.uniprot.org/uniprot/YFPE_SCHPO YFPE_SCHPO]]
-	[[Category: Mackereth~~, C.D~~]]	+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Schizosaccharomyces pombe]]
		+	[[Category: Kadlec J]]
		+	[[Category: Laroussi H]]
		+	[[Category: Mackereth CD]]

OCA at 04:57, 2 March 2022

2022-03-02T04:57:46Z

←Older revision		Revision as of 04:57, 2 March 2022
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7quu is ON HOLD	+	The entry 7quu is ON HOLD until Paper Publication

	Authors: Mackereth, C.D., Kadlec, J., Laroussi, H.		Authors: Mackereth, C.D., Kadlec, J., Laroussi, H.

OCA: Protected "7quu" [edit=sysop:move=sysop]

2022-01-27T05:24:10Z

Protected "7quu" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:24, 27 January 2022

OCA: New page: '''Unreleased structure''' The entry 7quu is ON HOLD Authors: Mackereth, C.D., Kadlec, J., Laroussi, H. Description: Red1-Iss10 complex Category: Unreleased Structures [[Category: ...

2022-01-27T05:24:08Z

New page: '''Unreleased structure''' The entry 7quu is ON HOLD Authors: Mackereth, C.D., Kadlec, J., Laroussi, H. Description: Red1-Iss10 complex Category: Unreleased Structures [[Category: ...

New page

'''Unreleased structure'''

The entry 7quu is ON HOLD

Authors: Mackereth, C.D., Kadlec, J., Laroussi, H.

Description: Red1-Iss10 complex
[[Category: Unreleased Structures]]
[[Category: Kadlec, J]]
[[Category: Laroussi, H]]
[[Category: Mackereth, C.D]]