OCA at 15:55, 27 October 2021

2021-10-27T15:55:31Z

←Older revision		Revision as of 15:55, 27 October 2021
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	==Crystal structure of a bacterial cyclic UMP synthase from Burkholderia cepacia LK29==		==Crystal structure of a bacterial cyclic UMP synthase from Burkholderia cepacia LK29==
-	<StructureSection load='7r65' size='340' side='right'caption='[[7r65]]' scene=''>	+	<StructureSection load='7r65' size='340' side='right'caption='[[7r65]], [[Resolution\|resolution]] 1.45Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7R65 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7R65 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7r65]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7R65 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7R65 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7r65 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7r65 OCA], [https://pdbe.org/7r65 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7r65 RCSB], [https://www.ebi.ac.uk/pdbsum/7r65 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7r65 ProSAT]</span></td></tr>	+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7r65 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7r65 OCA], [https://pdbe.org/7r65 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7r65 RCSB], [https://www.ebi.ac.uk/pdbsum/7r65 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7r65 ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The cyclic pyrimidines 3',5'-cyclic cytidine monophosphate (cCMP) and 3',5'-cyclic uridine monophosphate (cUMP) have been reported in multiple organisms and cell types. As opposed to the cyclic nucleotides 3',5'-cyclic adenosine monophosphate (cAMP) and 3',5'-cyclic guanosine monophosphate (cGMP), which are second messenger molecules with well-established regulatory roles across all domains of life, the biological role of cyclic pyrimidines has remained unclear. Here we report that cCMP and cUMP are second messengers functioning in bacterial immunity against viruses. We discovered a family of bacterial pyrimidine cyclase enzymes that specifically synthesize cCMP and cUMP following phage infection and demonstrate that these molecules activate immune effectors that execute an antiviral response. A crystal structure of a uridylate cyclase enzyme from this family explains the molecular mechanism of selectivity for pyrimidines as cyclization substrates. Defense systems encoding pyrimidine cyclases, denoted here Pycsar (pyrimidine cyclase system for antiphage resistance), are widespread in prokaryotes. Our results assign clear biological function to cCMP and cUMP as immunity signaling molecules in bacteria.
		+
		+	Cyclic CMP and cyclic UMP mediate bacterial immunity against phages.,Tal N, Morehouse BR, Millman A, Stokar-Avihail A, Avraham C, Fedorenko T, Yirmiya E, Herbst E, Brandis A, Mehlman T, Oppenheimer-Shaanan Y, Keszei AFA, Shao S, Amitai G, Kranzusch PJ, Sorek R Cell. 2021 Oct 7. pii: S0092-8674(21)01114-4. doi: 10.1016/j.cell.2021.09.031. PMID:34644530<ref>PMID:34644530</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7r65" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Kranzusch PJ]]	+	[[Category: Kranzusch, P J]]
-	[[Category: Morehouse BR]]	+	[[Category: Morehouse, B R]]
		+	[[Category: Bacteriophage-defense]]
		+	[[Category: Cyclic nucleotide]]
		+	[[Category: Nucleotidyltransferase]]
		+	[[Category: Pycsar]]
		+	[[Category: Transferase]]

OCA at 11:46, 13 October 2021

2021-10-13T11:46:36Z

←Older revision		Revision as of 11:46, 13 October 2021
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-	'''Unreleased structure'''

-	~~The entry~~ 7r65 ~~is ON HOLD until Paper Publication~~	+	==Crystal structure of a bacterial cyclic UMP synthase from Burkholderia cepacia LK29==
-		+	<StructureSection load='7r65' size='340' side='right'caption='[[7r65]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7R65 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7R65 FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7r65 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7r65 OCA], [https://pdbe.org/7r65 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7r65 RCSB], [https://www.ebi.ac.uk/pdbsum/7r65 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7r65 ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Kranzusch PJ]]
		+	[[Category: Morehouse BR]]

OCA: Protected "7r65" [edit=sysop:move=sysop]

2021-07-02T02:38:15Z

Protected "7r65" [edit=sysop:move=sysop]

←Older revision

Revision as of 02:38, 2 July 2021

OCA: New page: '''Unreleased structure''' The entry 7r65 is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

2021-07-02T02:38:14Z

New page: '''Unreleased structure''' The entry 7r65 is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7r65 is ON HOLD until Paper Publication

Authors:

Description:
[[Category: Unreleased Structures]]

7r65 - Revision history

OCA at 15:55, 27 October 2021

OCA at 11:46, 13 October 2021

OCA: Protected "7r65" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 7r65 is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures