OCA at 09:40, 15 September 2021

2021-09-15T09:40:07Z

←Older revision		Revision as of 09:40, 15 September 2021
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	==Structure of TRPV3 in complex with osthole==		==Structure of TRPV3 in complex with osthole==
-	<StructureSection load='7ras' size='340' side='right'caption='[[7ras]]' scene=''>	+	<StructureSection load='7ras' size='340' side='right'caption='[[7ras]], [[Resolution\|resolution]] 3.64Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7RAS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7RAS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7ras]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7RAS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7RAS FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ras FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ras OCA], [https://pdbe.org/7ras PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ras RCSB], [https://www.ebi.ac.uk/pdbsum/7ras PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ras ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A0O:7-methoxy-8-(3-methylbut-2-enyl)chromen-2-one'>A0O</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Trpv3 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ras FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ras OCA], [https://pdbe.org/7ras PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ras RCSB], [https://www.ebi.ac.uk/pdbsum/7ras PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ras ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[https://www.uniprot.org/uniprot/TRPV3_MOUSE TRPV3_MOUSE]] Putative receptor-activated non-selective calcium permeant cation channel. It is activated by innocuous (warm) temperatures and shows an increased response at noxious temperatures greater than 39 degrees Celsius. Activation exhibits an outward rectification. May associate with TRPV1 and may modulate its activity. Is a negative regulator of hair growth and cycling: TRPV3-coupled signaling suppresses keratinocyte proliferation in hair follicles and induces apoptosis and premature hair follicle regression (catagen) (By similarity).
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	TRPV3, a representative of the vanilloid subfamily of TRP channels, is predominantly expressed in skin keratinocytes and has been implicated in cutaneous sensation and associated with numerous skin pathologies and cancers. TRPV3 is inhibited by the natural coumarin derivative osthole, an active ingredient of Cnidium monnieri, which has been used in traditional Chinese medicine for the treatment of a variety of human diseases. However, the structural basis of channel inhibition by osthole has remained elusive. Here we present cryo-EM structures of TRPV3 in complex with osthole, revealing two types of osthole binding sites in the transmembrane region of TRPV3 that coincide with the binding sites of agonist 2-APB. Osthole binding converts the channel pore into a previously unidentified conformation with a widely open selectivity filter and closed intracellular gate. Our structures provide insight into competitive inhibition of TRPV3 by osthole and can serve as a template for the design of osthole chemistry-inspired drugs targeting TRPV3-associated diseases.
		+
		+	Structural mechanism of TRPV3 channel inhibition by the plant-derived coumarin osthole.,Neuberger A, Nadezhdin KD, Zakharian E, Sobolevsky AI EMBO Rep. 2021 Sep 2:e53233. doi: 10.15252/embr.202153233. PMID:34472684<ref>PMID:34472684</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7ras" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Nadezhdin KD]]	+	[[Category: Lk3 transgenic mice]]
-	[[Category: Neuberger A]]	+	[[Category: Nadezhdin, K D]]
-	[[Category: Sobolevsky AI]]	+	[[Category: Neuberger, A]]
		+	[[Category: Sobolevsky, A I]]
		+	[[Category: Membrane protein]]
		+	[[Category: Trp channel]]
		+	[[Category: V3]]

OCA at 08:59, 8 September 2021

2021-09-08T08:59:38Z

←Older revision		Revision as of 08:59, 8 September 2021
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-	'''Unreleased structure'''

-	~~The entry~~ 7ras is ~~ON HOLD until Paper Publication~~	+	==Structure of TRPV3 in complex with osthole==
-		+	<StructureSection load='7ras' size='340' side='right'caption='[[7ras]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7RAS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7RAS FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ras FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ras OCA], [https://pdbe.org/7ras PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ras RCSB], [https://www.ebi.ac.uk/pdbsum/7ras PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ras ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Nadezhdin KD]]
		+	[[Category: Neuberger A]]
		+	[[Category: Sobolevsky AI]]

OCA at 05:08, 11 August 2021

2021-08-11T05:08:27Z

←Older revision		Revision as of 05:08, 11 August 2021
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7ras is ON HOLD	+	The entry 7ras is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7ras" [edit=sysop:move=sysop]

2021-07-14T08:54:56Z

Protected "7ras" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:54, 14 July 2021

OCA: New page: '''Unreleased structure''' The entry 7ras is ON HOLD Authors: Description: Category: Unreleased Structures

2021-07-14T08:54:55Z

New page: '''Unreleased structure''' The entry 7ras is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7ras is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

7ras - Revision history

OCA at 09:40, 15 September 2021

OCA at 08:59, 8 September 2021

OCA at 05:08, 11 August 2021

OCA: Protected "7ras" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 7ras is ON HOLD Authors: Description: Category: Unreleased Structures