OCA at 16:29, 18 October 2023

2023-10-18T16:29:50Z

←Older revision		Revision as of 16:29, 18 October 2023
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	==Crystal structure of the first bromodomain (BD1) of human BRD4 in complex with dual BRD4-JAK2 inhibitor PN1-050==		==Crystal structure of the first bromodomain (BD1) of human BRD4 in complex with dual BRD4-JAK2 inhibitor PN1-050==
-	<StructureSection load='7rem' size='340' side='right'caption='[[7rem]]' scene=''>	+	<StructureSection load='7rem' size='340' side='right'caption='[[7rem]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7REM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7REM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7rem]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7REM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7REM FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7rem FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7rem OCA], [https://pdbe.org/7rem PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7rem RCSB], [https://www.ebi.ac.uk/pdbsum/7rem PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7rem ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4OF:N-[2-chloro-5-({2-[3-fluoro-4-(1-methylpiperidin-4-yl)anilino]-5-(trifluoromethyl)pyrimidin-4-yl}amino)phenyl]-2-methylpropane-2-sulfonamide'>4OF</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7rem FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7rem OCA], [https://pdbe.org/7rem PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7rem RCSB], [https://www.ebi.ac.uk/pdbsum/7rem PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7rem ProSAT]</span></td></tr>
	</table>		</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
		+
		+	==See Also==
		+	*[[Bromodomain-containing protein 3D structures\|Bromodomain-containing protein 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Karim MR]]		[[Category: Karim MR]]
	[[Category: Schonbrunn E]]		[[Category: Schonbrunn E]]

OCA: Protected "7rem" [edit=sysop:move=sysop]

2021-07-21T09:00:32Z

Protected "7rem" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:00, 21 July 2021

OCA: New page: ==Crystal structure of the first bromodomain (BD1) of human BRD4 in complex with dual BRD4-JAK2 inhibitor PN1-050==
2021-07-21T09:00:31Z

New page: ==Crystal structure of the first bromodomain (BD1) of human BRD4 in complex with dual BRD4-JAK2 inhibitor PN1-050== <StructureSection load='7rem' size='340' side='right'caption='7rem'...

New page

==Crystal structure of the first bromodomain (BD1) of human BRD4 in complex with dual BRD4-JAK2 inhibitor PN1-050==
<StructureSection load='7rem' size='340' side='right'caption='[[7rem]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7REM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7REM FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7rem FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7rem OCA], [https://pdbe.org/7rem PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7rem RCSB], [https://www.ebi.ac.uk/pdbsum/7rem PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7rem ProSAT]</span></td></tr>
</table>
TOC
</StructureSection>
[[Category: Large Structures]]
[[Category: Karim MR]]
[[Category: Schonbrunn E]]

7rem - Revision history

OCA at 16:29, 18 October 2023

OCA: Protected "7rem" [edit=sysop:move=sysop]