OCA at 16:34, 18 October 2023

2023-10-18T16:34:31Z

←Older revision		Revision as of 16:34, 18 October 2023
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	==Crystal structure of Saccharomyces cerevisiae NADH-cytochrome b5 reductase 1 (Cbr1) fragment (residues 28-284) bound to FAD==		==Crystal structure of Saccharomyces cerevisiae NADH-cytochrome b5 reductase 1 (Cbr1) fragment (residues 28-284) bound to FAD==
-	<StructureSection load='7rom' size='340' side='right'caption='[[7rom]]' scene=''>	+	<StructureSection load='7rom' size='340' side='right'caption='[[7rom]], [[Resolution\|resolution]] 1.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ROM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ROM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7rom]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ROM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ROM FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7rom FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7rom OCA], [https://pdbe.org/7rom PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7rom RCSB], [https://www.ebi.ac.uk/pdbsum/7rom PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7rom ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.65Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7rom FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7rom OCA], [https://pdbe.org/7rom PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7rom RCSB], [https://www.ebi.ac.uk/pdbsum/7rom PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7rom ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/NCB5R_YEAST NCB5R_YEAST] NADH-dependent reductase for KTI11/DPH3 and cytochrome b5 (PubMed:14930, PubMed:10622712, PubMed:27694803, PubMed:31463593, PubMed:34154323). Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2 (PubMed:31463593, PubMed:34154323, PubMed:27694803). DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising KTI11/DPH3 and a NADH-dependent reductase, predominantly CBR1 (PubMed:31463593, PubMed:34154323). By reducing KTI11/DPH3, also involved in the formation of the tRNA wobble base modification mcm5s 2U (5-methoxycarbonylmethyl-2-thiouridine), mediated by the elongator complex (PubMed:27694803). The cytochrome b5/NADH cytochrome b5 reductase electron transfer system supports the catalytic activity of several sterol biosynthetic enzymes (PubMed:10622712). Plays a role in bud morphology (PubMed:17895367).<ref>PMID:10622712</ref> <ref>PMID:14930</ref> <ref>PMID:17895367</ref> <ref>PMID:27694803</ref> <ref>PMID:31463593</ref> <ref>PMID:34154323</ref>
		+
		+	==See Also==
		+	*[[NADH-cytochrome b5 reductase\|NADH-cytochrome b5 reductase]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
		+	[[Category: Saccharomyces cerevisiae]]
	[[Category: Fenwick MK]]		[[Category: Fenwick MK]]
	[[Category: Lin H]]		[[Category: Lin H]]
	[[Category: Zhang Y]]		[[Category: Zhang Y]]

OCA at 04:59, 10 August 2022

2022-08-10T04:59:54Z

←Older revision		Revision as of 04:59, 10 August 2022
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-	'''Unreleased structure'''

-	~~The entry~~ 7rom is ~~ON HOLD until Paper Publication~~	+	==Crystal structure of Saccharomyces cerevisiae NADH-cytochrome b5 reductase 1 (Cbr1) fragment (residues 28-284) bound to FAD==
-		+	<StructureSection load='7rom' size='340' side='right'caption='[[7rom]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ROM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ROM FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7rom FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7rom OCA], [https://pdbe.org/7rom PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7rom RCSB], [https://www.ebi.ac.uk/pdbsum/7rom PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7rom ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Fenwick MK]]
		+	[[Category: Lin H]]
		+	[[Category: Zhang Y]]

OCA: Protected "7rom" [edit=sysop:move=sysop]

2021-08-11T05:11:26Z

Protected "7rom" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:11, 11 August 2021

OCA: New page: '''Unreleased structure''' The entry 7rom is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

2021-08-11T05:11:25Z

New page: '''Unreleased structure''' The entry 7rom is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7rom is ON HOLD until Paper Publication

Authors:

Description:
[[Category: Unreleased Structures]]

7rom - Revision history

OCA at 16:34, 18 October 2023

OCA at 04:59, 10 August 2022

OCA: Protected "7rom" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 7rom is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures