7rwm - Revision history

OCA at 16:39, 18 October 2023

2023-10-18T16:39:53Z

←Older revision		Revision as of 16:39, 18 October 2023
Line 3:		Line 3:
	<StructureSection load='7rwm' size='340' side='right'caption='[[7rwm]], [[Resolution\|resolution]] 3.40Å' scene=''>		<StructureSection load='7rwm' size='340' side='right'caption='[[7rwm]], [[Resolution\|resolution]] 3.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[7rwm]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7RWM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7RWM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7rwm]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Lactococcus_lactis_subsp._cremoris_IBB477 Lactococcus lactis subsp. cremoris IBB477]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7RWM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7RWM FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.4Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7rwm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7rwm OCA], [https://pdbe.org/7rwm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7rwm RCSB], [https://www.ebi.ac.uk/pdbsum/7rwm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7rwm ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7rwm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7rwm OCA], [https://pdbe.org/7rwm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7rwm RCSB], [https://www.ebi.ac.uk/pdbsum/7rwm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7rwm ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A0A1E7G0A2_LACLC A0A1E7G0A2_LACLC]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 20:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Lactococcus lactis subsp. cremoris IBB477]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Chakravarti, A]]	+	[[Category: Chakravarti A]]
-	[[Category: Fatma, S]]	+	[[Category: Fatma S]]
-	[[Category: Huang~~, R H]]~~	+	[[Category: Huang RH]]
-	~~[[Category: Dna nuclease saved sensor effector]]~~	+
-	~~[[Category: Unknown function~~]]	+

OCA at 12:52, 24 November 2021

2021-11-24T12:52:21Z

←Older revision		Revision as of 12:52, 24 November 2021
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7rwm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7rwm OCA], [https://pdbe.org/7rwm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7rwm RCSB], [https://www.ebi.ac.uk/pdbsum/7rwm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7rwm ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7rwm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7rwm OCA], [https://pdbe.org/7rwm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7rwm RCSB], [https://www.ebi.ac.uk/pdbsum/7rwm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7rwm ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Cyclic-oligonucleotide-based antiphage signaling systems (CBASS) are diverse and abundant in bacteria. Here, we present the biochemical and structural characterization of two CBASS systems, composed of CdnG and Cap5, from Asticcacaulis sp. and Lactococcus lactis. We show that CdnG from Asticcacaulis sp. synthesizes 3',2'-cGAMP in vitro, and 3',2'-cGAMP is the biological signaling molecule that activates Cap5 for DNA degradation. Crystal structures of Cap5, together with the SAVED domain in complex with 3',2'-cGAMP, provide insight into the architecture of Cap5 as well as molecular recognition of 3',2'-cGAMP by the SAVED domain of Cap5. Amino acid conservation of the SAVED domain of Cap5, together with mutational studies, led us to propose a mechanism of Back-to-Front stacking of two SAVED domains, mediated by 3',2'-cGAMP, to activate HNH nuclease domain for DNA degradation. This study of the most abundant CBASS system provides insights into the mechanisms employed by bacteria in their conflicts against phage.
		+
		+	Molecular mechanisms of the CdnG-Cap5 antiphage defense system employing 3',2'-cGAMP as the second messenger.,Fatma S, Chakravarti A, Zeng X, Huang RH Nat Commun. 2021 Nov 4;12(1):6381. doi: 10.1038/s41467-021-26738-2. PMID:34737303<ref>PMID:34737303</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7rwm" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 14:20, 17 November 2021

2021-11-17T14:20:04Z

←Older revision		Revision as of 14:20, 17 November 2021
Line 1:		Line 1:

	==Structure of Cap5 from Lactococcus lactis==		==Structure of Cap5 from Lactococcus lactis==
-	<StructureSection load='7rwm' size='340' side='right'caption='[[7rwm]]' scene=''>	+	<StructureSection load='7rwm' size='340' side='right'caption='[[7rwm]], [[Resolution\|resolution]] 3.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7RWM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7RWM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7rwm]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7RWM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7RWM FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7rwm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7rwm OCA], [https://pdbe.org/7rwm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7rwm RCSB], [https://www.ebi.ac.uk/pdbsum/7rwm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7rwm ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7rwm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7rwm OCA], [https://pdbe.org/7rwm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7rwm RCSB], [https://www.ebi.ac.uk/pdbsum/7rwm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7rwm ProSAT]</span></td></tr>
	</table>		</table>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Chakravarti A]]	+	[[Category: Chakravarti, A]]
-	[[Category: Fatma S]]	+	[[Category: Fatma, S]]
-	[[Category: Huang RH]]	+	[[Category: Huang, R H]]
		+	[[Category: Dna nuclease saved sensor effector]]
		+	[[Category: Unknown function]]

OCA at 06:17, 10 November 2021

2021-11-10T06:17:07Z

←Older revision		Revision as of 06:17, 10 November 2021
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 7rwm is ~~ON HOLD until Paper Publication~~	+	==Structure of Cap5 from Lactococcus lactis==
-		+	<StructureSection load='7rwm' size='340' side='right'caption='[[7rwm]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7RWM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7RWM FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7rwm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7rwm OCA], [https://pdbe.org/7rwm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7rwm RCSB], [https://www.ebi.ac.uk/pdbsum/7rwm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7rwm ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Chakravarti A]]
		+	[[Category: Fatma S]]
		+	[[Category: Huang RH]]

OCA at 07:43, 29 September 2021

2021-09-29T07:43:12Z

←Older revision		Revision as of 07:43, 29 September 2021
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7rwm is ON HOLD	+	The entry 7rwm is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7rwm" [edit=sysop:move=sysop]

2021-09-08T07:45:46Z

Protected "7rwm" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:45, 8 September 2021

OCA: New page: '''Unreleased structure''' The entry 7rwm is ON HOLD Authors: Description: Category: Unreleased Structures

2021-09-08T07:45:45Z

New page: '''Unreleased structure''' The entry 7rwm is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7rwm is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]