OCA at 11:09, 16 February 2022

2022-02-16T11:09:35Z

←Older revision		Revision as of 11:09, 16 February 2022
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	==Structure of the complex of AMPA receptor GluA2 with auxiliary subunit TARP gamma-5 bound to agonist Quisqualate==		==Structure of the complex of AMPA receptor GluA2 with auxiliary subunit TARP gamma-5 bound to agonist Quisqualate==
-	<StructureSection load='7rz7' size='340' side='right'caption='[[7rz7]]' scene=''>	+	<StructureSection load='7rz7' size='340' side='right'caption='[[7rz7]], [[Resolution\|resolution]] 4.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7RZ7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7RZ7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7rz7]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7RZ7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7RZ7 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7rz7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7rz7 OCA], [https://pdbe.org/7rz7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7rz7 RCSB], [https://www.ebi.ac.uk/pdbsum/7rz7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7rz7 ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=QUS:(S)-2-AMINO-3-(3,5-DIOXO-[1,2,4]OXADIAZOLIDIN-2-YL)-PROPIONIC+ACID'>QUS</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7rz7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7rz7 OCA], [https://pdbe.org/7rz7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7rz7 RCSB], [https://www.ebi.ac.uk/pdbsum/7rz7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7rz7 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[https://www.uniprot.org/uniprot/GRIA2_RAT GRIA2_RAT]] Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.<ref>PMID:9351977</ref> <ref>PMID:19265014</ref> <ref>PMID:21172611</ref> <ref>PMID:12501192</ref> <ref>PMID:12015593</ref> <ref>PMID:12872125</ref> <ref>PMID:12730367</ref> <ref>PMID:16192394</ref> <ref>PMID:15591246</ref> <ref>PMID:17018279</ref> <ref>PMID:16483599</ref> <ref>PMID:19946266</ref> <ref>PMID:21317873</ref> <ref>PMID:21846932</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	AMPA receptors (AMPARs) mediate the majority of excitatory neurotransmission. Their surface expression, trafficking, gating, and pharmacology are regulated by auxiliary subunits. Of the two types of TARP auxiliary subunits, type I TARPs assume activating roles, while type II TARPs serve suppressive functions. We present cryo-EM structures of GluA2 AMPAR in complex with type II TARP gamma5, which reduces steady-state currents, increases single-channel conductance, and slows recovery from desensitization. Regulation of AMPAR function depends on its ligand-binding domain (LBD) interaction with the gamma5 head domain. GluA2-gamma5 complex shows maximum stoichiometry of two TARPs per AMPAR tetramer, being different from type I TARPs but reminiscent of the auxiliary subunit GSG1L. Desensitization of both GluA2-GSG1L and GluA2-gamma5 complexes is accompanied by rupture of LBD dimer interface, while GluA2-gamma5 but not GluA2-GSG1L LBD dimers remain two-fold symmetric. Different structural architectures and desensitization mechanisms of complexes with auxiliary subunits endow AMPARs with broad functional capabilities.
		+
		+	Structure and desensitization of AMPA receptor complexes with type II TARP gamma5 and GSG1L.,Klykov O, Gangwar SP, Yelshanskaya MV, Yen L, Sobolevsky AI Mol Cell. 2021 Dec 2;81(23):4771-4783.e7. doi: 10.1016/j.molcel.2021.09.030. Epub, 2021 Oct 21. PMID:34678168<ref>PMID:34678168</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7rz7" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Gangwar SP]]	+	[[Category: Gangwar, S P]]
-	[[Category: Klykov OV]]	+	[[Category: Klykov, O V]]
-	[[Category: Sobolevsky AI]]	+	[[Category: Sobolevsky, A I]]
-	[[Category: Yelshanskaya MV]]	+	[[Category: Yelshanskaya, M V]]
		+	[[Category: Ampa receptor]]
		+	[[Category: Ion channel]]
		+	[[Category: Membrane protein]]
		+	[[Category: Neurotransmission]]
		+	[[Category: Synapse]]
		+	[[Category: Tarp gamma-5]]

OCA at 14:14, 27 October 2021

2021-10-27T14:14:30Z

←Older revision		Revision as of 14:14, 27 October 2021
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-	'''Unreleased structure'''

-	~~The entry~~ 7rz7 is ~~ON HOLD until Paper Publication~~	+	==Structure of the complex of AMPA receptor GluA2 with auxiliary subunit TARP gamma-5 bound to agonist Quisqualate==
-		+	<StructureSection load='7rz7' size='340' side='right'caption='[[7rz7]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7RZ7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7RZ7 FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7rz7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7rz7 OCA], [https://pdbe.org/7rz7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7rz7 RCSB], [https://www.ebi.ac.uk/pdbsum/7rz7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7rz7 ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Gangwar SP]]
		+	[[Category: Klykov OV]]
		+	[[Category: Sobolevsky AI]]
		+	[[Category: Yelshanskaya MV]]

OCA at 04:11, 6 October 2021

2021-10-06T04:11:25Z

←Older revision		Revision as of 04:11, 6 October 2021
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7rz7 is ON HOLD	+	The entry 7rz7 is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7rz7" [edit=sysop:move=sysop]

2021-09-08T07:49:13Z

Protected "7rz7" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:49, 8 September 2021

OCA: New page: '''Unreleased structure''' The entry 7rz7 is ON HOLD Authors: Description: Category: Unreleased Structures

2021-09-08T07:49:12Z

New page: '''Unreleased structure''' The entry 7rz7 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7rz7 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

7rz7 - Revision history

OCA at 11:09, 16 February 2022

OCA at 14:14, 27 October 2021

OCA at 04:11, 6 October 2021

OCA: Protected "7rz7" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 7rz7 is ON HOLD Authors: Description: Category: Unreleased Structures