7s9g - Revision history

OCA at 16:47, 18 October 2023

2023-10-18T16:47:51Z

←Older revision		Revision as of 16:47, 18 October 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[7s9g]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7S9G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7S9G FirstGlance]. <br>		<table><tr><td colspan='2'>[[7s9g]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7S9G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7S9G FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=94M:6-CHLORO-9-[(4-METHOXY-3,5-DIMETHYLPYRIDIN-2-YL)METHYL]-9H-PURIN-2-AMINE'>94M</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.79Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=94M:6-CHLORO-9-[(4-METHOXY-3,5-DIMETHYLPYRIDIN-2-YL)METHYL]-9H-PURIN-2-AMINE'>94M</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7s9g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7s9g OCA], [https://pdbe.org/7s9g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7s9g RCSB], [https://www.ebi.ac.uk/pdbsum/7s9g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7s9g ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7s9g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7s9g OCA], [https://pdbe.org/7s9g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7s9g RCSB], [https://www.ebi.ac.uk/pdbsum/7s9g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7s9g ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN]] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>	+	[https://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 7s9g" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 7s9g" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Heat Shock Protein structures\|Heat Shock Protein structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 03:15, 8 September 2022

2022-09-08T03:15:04Z

←Older revision		Revision as of 03:15, 8 September 2022
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	==Room-temperature Human Hsp90a-NTD bound to BIIB021==		==Room-temperature Human Hsp90a-NTD bound to BIIB021==
-	<StructureSection load='7s9g' size='340' side='right'caption='[[7s9g]]' scene=''>	+	<StructureSection load='7s9g' size='340' side='right'caption='[[7s9g]], [[Resolution\|resolution]] 1.79Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7S9G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7S9G FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[7s9g]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7S9G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7S9G FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7s9g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7s9g OCA], [https://pdbe.org/7s9g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7s9g RCSB], [https://www.ebi.ac.uk/pdbsum/7s9g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7s9g ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=94M:6-CHLORO-9-[(4-METHOXY-3,5-DIMETHYLPYRIDIN-2-YL)METHYL]-9H-PURIN-2-AMINE'>94M</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7s9g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7s9g OCA], [https://pdbe.org/7s9g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7s9g RCSB], [https://www.ebi.ac.uk/pdbsum/7s9g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7s9g ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[https://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN]] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	High-resolution crystal structures highlight the importance of water networks in protein-ligand interactions. However, as these are typically determined at cryogenic temperature, resulting insights may be structurally precise but not biologically accurate. By collecting 10 matched room-temperature and cryogenic datasets of the biomedical target Hsp90alpha, we identified changes in water networks that impact protein conformations at the ligand binding interface. Water repositioning with temperature repopulates protein ensembles and ligand interactions. We introduce Flipper conformational barcodes to identify temperature-sensitive regions in electron density maps. This revealed that temperature-responsive states coincide with ligand-responsive regions and capture unique binding signatures that disappear upon cryo-cooling. Our results have implications for discovering Hsp90 selective ligands, and, more generally, for the utility of hidden protein and water conformations in drug discovery.
		+
		+	Water Networks Repopulate Protein-Ligand Interfaces with Temperature.,Stachowski TR, Vanarotti M, Seetharaman J, Lopez K, Fischer M Angew Chem Int Ed Engl. 2022 Aug 1;61(31):e202112919. doi:, 10.1002/anie.202112919. Epub 2022 Jun 21. PMID:35648650<ref>PMID:35648650</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 7s9g" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Fischer M]]		[[Category: Fischer M]]
	[[Category: Stachowski TR]]		[[Category: Stachowski TR]]
	[[Category: Vanarotti M]]		[[Category: Vanarotti M]]

OCA at 04:52, 3 August 2022

2022-08-03T04:52:48Z

←Older revision		Revision as of 04:52, 3 August 2022
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-	'''Unreleased structure'''

-	~~The entry~~ 7s9g is ~~ON HOLD until Paper Publication~~	+	==Room-temperature Human Hsp90a-NTD bound to BIIB021==
-		+	<StructureSection load='7s9g' size='340' side='right'caption='[[7s9g]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7S9G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7S9G FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7s9g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7s9g OCA], [https://pdbe.org/7s9g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7s9g RCSB], [https://www.ebi.ac.uk/pdbsum/7s9g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7s9g ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Fischer M]]
		+	[[Category: Stachowski TR]]
		+	[[Category: Vanarotti M]]

OCA at 04:13, 6 October 2021

2021-10-06T04:13:39Z

←Older revision		Revision as of 04:13, 6 October 2021
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7s9g is ON HOLD	+	The entry 7s9g is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7s9g" [edit=sysop:move=sysop]

2021-09-29T07:48:45Z

Protected "7s9g" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:48, 29 September 2021

OCA: New page: '''Unreleased structure''' The entry 7s9g is ON HOLD Authors: Description: Category: Unreleased Structures

2021-09-29T07:48:44Z

New page: '''Unreleased structure''' The entry 7s9g is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7s9g is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]