7sch - Revision history

OCA at 07:41, 18 January 2023

2023-01-18T07:41:37Z

←Older revision		Revision as of 07:41, 18 January 2023
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	</table>		</table>
	== Disease ==		== Disease ==
-	[[https://www.uniprot.org/uniprot/EXT1_HUMAN EXT1_HUMAN]] Chondrosarcoma;Multiple osteochondromas;Trichorhinophalangeal syndrome type 2. The disease is caused by variants affecting the gene represented in this entry. The gene represented in this entry is involved in disease pathogenesis. A chromosomal aberration resulting in the loss of functional copies of TRPS1 and EXT1 has been found in TRPS2 patients. The disease is caused by variants affecting the gene represented in this entry.	+	[https://www.uniprot.org/uniprot/EXT1_HUMAN EXT1_HUMAN] Chondrosarcoma;Multiple osteochondromas;Trichorhinophalangeal syndrome type 2. The disease is caused by variants affecting the gene represented in this entry. The gene represented in this entry is involved in disease pathogenesis. A chromosomal aberration resulting in the loss of functional copies of TRPS1 and EXT1 has been found in TRPS2 patients. The disease is caused by variants affecting the gene represented in this entry.
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/EXT1_HUMAN EXT1_HUMAN]] Glycosyltransferase required for the biosynthesis of heparan-sulfate. The EXT1/EXT2 complex possesses substantially higher glycosyltransferase activity than EXT1 or EXT2 alone. Appears to be a tumor suppressor. Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413).<ref>PMID:11518722</ref> <ref>PMID:22660413</ref>	+	[https://www.uniprot.org/uniprot/EXT1_HUMAN EXT1_HUMAN] Glycosyltransferase required for the biosynthesis of heparan-sulfate. The EXT1/EXT2 complex possesses substantially higher glycosyltransferase activity than EXT1 or EXT2 alone. Appears to be a tumor suppressor. Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413).<ref>PMID:11518722</ref> <ref>PMID:22660413</ref>
	== References ==		== References ==
	<references/>		<references/>

OCA at 06:14, 28 September 2022

2022-09-28T06:14:41Z

←Older revision		Revision as of 06:14, 28 September 2022
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-	'''Unreleased structure'''

-	The entry ~~7sch~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	==Cryo-EM structure of the human Exostosin-1 and Exostosin-2 heterodimer==
-		+	<StructureSection load='7sch' size='340' side='right'caption='[[7sch]], [[Resolution\|resolution]] 3.10Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[7sch]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7SCH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7SCH FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7sch FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7sch OCA], [https://pdbe.org/7sch PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7sch RCSB], [https://www.ebi.ac.uk/pdbsum/7sch PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7sch ProSAT]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[https://www.uniprot.org/uniprot/EXT1_HUMAN EXT1_HUMAN]] Chondrosarcoma;Multiple osteochondromas;Trichorhinophalangeal syndrome type 2. The disease is caused by variants affecting the gene represented in this entry. The gene represented in this entry is involved in disease pathogenesis. A chromosomal aberration resulting in the loss of functional copies of TRPS1 and EXT1 has been found in TRPS2 patients. The disease is caused by variants affecting the gene represented in this entry.
		+	== Function ==
		+	[[https://www.uniprot.org/uniprot/EXT1_HUMAN EXT1_HUMAN]] Glycosyltransferase required for the biosynthesis of heparan-sulfate. The EXT1/EXT2 complex possesses substantially higher glycosyltransferase activity than EXT1 or EXT2 alone. Appears to be a tumor suppressor. Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413).<ref>PMID:11518722</ref> <ref>PMID:22660413</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Li H]]

OCA at 03:49, 8 June 2022

2022-06-08T03:49:12Z

←Older revision		Revision as of 03:49, 8 June 2022
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7sch is ON HOLD	+	The entry 7sch is ON HOLD until Paper Publication

	Authors:		Authors:

OCA at 11:27, 4 May 2022

2022-05-04T11:27:42Z

←Older revision		Revision as of 11:27, 4 May 2022
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7sch is ON HOLD ~~until Paper Publication~~	+	The entry 7sch is ON HOLD

	Authors:		Authors:

OCA at 12:49, 3 November 2021

2021-11-03T12:49:33Z

←Older revision		Revision as of 12:49, 3 November 2021
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 7sch is ON HOLD	+	The entry 7sch is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "7sch" [edit=sysop:move=sysop]

2021-10-06T04:16:13Z

Protected "7sch" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:16, 6 October 2021

OCA: New page: '''Unreleased structure''' The entry 7sch is ON HOLD Authors: Description: Category: Unreleased Structures

2021-10-06T04:16:12Z

New page: '''Unreleased structure''' The entry 7sch is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 7sch is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]